Etoricoxib‐induced toxic epidermal necrolysis

Moutran, Roy; Maatouk, Ismaël; Hélou, Josiane

doi:10.1111/ijd.12154

Cited by 7 publications

(5 citation statements)

References 9 publications

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“…23 In these clinical entities, the duration from the drug intake to the first onset of a symptom may range between few hours and 45 days, and the recovery time may be very long because re-epithelization of the skin or mucosa could be achieved within several weeks. 22,24 This can happen even after a single dose of drug, as reported, for example, for ibuprofen 25 and etoricoxib 19 and as in our case.…”

Section: Case Descriptionsupporting

confidence: 79%

Mucosal exfoliation as a selective reaction to etoricoxib

et al. 2016

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Section: Case Descriptionsupporting

confidence: 79%

Mucosal exfoliation as a selective reaction to etoricoxib

et al. 2016

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“…29 Conversly, COX-2 inhibitors, celecoxib and rofecoxib, did not show such an association, 34 although cases of etoricoxib-induced TEN have been reported. 32,33 In our setting, systemic oxicam-NSAIDs are not widely used, and we found COX-2 inhibitor etoricoxib as the most frequently reported NSAID associated with SJS/TEN instead.…”

Section: Stevens-johnson Syndrome Toxic Epidermal Necrolysis (Sjs/mentioning

confidence: 69%

“…Telogen hair loss is linked to a wider variety of endogenous (17); Doxycycline (16); Aspirin (14); Mefenamic Acid (14) DHS 325 Allopurinol (57); Phenytoin (39); Cotrimoxazole (33); Carbamazepine (20); Dapsone (14); Sulfasalazine (9); Diclofenac (9); Omeprazole (8); Piperacilin & Tazobactam (7); Vancomycin (6); Coamoxiclav (6), Isoniazid (6); Rifampicin (6) Photosensitivity 123 Hydrochlorothiazide (37); Doxycycline (10); Fenofibrate (7); Simvastatin (5); Ciprofloxacin (4); Griseofulvin (4); Tetracycline (3); Nifedipine (2); Entecavir (2); Glipizide (2); Hydroxychloroquine (2); Coamoxiclav (2); Amiodarone (2); Atenolol (2); Chlorpromazine (2); Ofloxacin (2) Alopecia 75 Azathioprine (6); Losartan (5); Leflunomide (5); Amlodipine (4); Atenolol (4); Fluconazole (4); Simvastatin (4); Valproate (3); Nilotinib (3); Acarbose (2); Carbimazole (2); Metformin (2); Imatinib (2); Lisinopril (2); Tolbutamide (2) Skin Discoloration 62 Simvastatin (5); Cotrimoxazole (5); Amiodarone (2); Laropiprant and Niacin(2); Tetracycline (2); Enalapril (2); Aspirin (2); Ciprofloxacin (2) a The number of drugs involved ≠ number of reports for CADR as more than 1 drug could be suspected in a single report.…”

Section: Alopeciamentioning

confidence: 99%

Spontaneous cutaneous adverse drug reaction reports—An analysis of a 10‐year dataset in Singapore

Wong

Tham

Goh

et al. 2019

Pharmacology Res & Perspec

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We analyzed the spontaneous adverse event database in Singapore to determine the types of cutaneous adverse drug reactions ( CADR s) and causative drugs reported. We selected 10 CADR s‐of‐interest, and identified the suspected drugs and the characteristics of the at‐risk population. ADR reports received from 2006 to 2015 of the system organ class “Skin and Appendages Disorders” were analyzed based on patient demographics, the types of CADR s, suspected drugs, outcome, and latency period. Of the 104 372 reports analyzed, 56.2% involved females and 72.5% involved Chinese patients. The mean age was 41.1 years old. The top CADR s reported were rash (including nonspecified rash, follicular rash, maculopapular rash, and vesicular rash) (67.2%) and angioedema (13.9%). The drugs frequently associated with the CADR s‐of‐interest include nonsteroidal antiinflammatory drugs and antibiotics with angioedema, iohexol with urticaria, and antiepileptics and allopurinol with Stevens‐Johnson syndrome ( SJS )/toxic epidermal necrolysis ( TEN ). A subgroup analysis based on age, sex, and race on the 10 CADR s‐of‐interest showed the following trends in reporting: Alopecia (reported more in females), drug hypersensitivity syndrome (more in males), angioedema (more in younger patients), and photosensitivity (more in older patients). In general, the racial distribution across each CADR ‐of‐interest was consistent with that of Singapore's population, with slight deviations observed for SJS / TEN , photosensitivity and skin discoloration. We analyzed CADR reports from Singapore over 10 years, and identified the types of CADR s reported, and their associated drugs, latency periods and patient characteristics. Such information could add value to healthcare professionals as they assess CADR cases and evaluate suspected drugs.

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“…Its potential to cause adverse reactions must not be neglected. These include immediate hypersensitivity reactions, FDE, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis . Cross reactivity between COX2‐specific inhibitors in FDE is not well‐studied but it has been previously reported that a patient with etoricoxib‐induced FDE was able to tolerate celecoxib, a COX2‐specific inhibitor with similar pharmacological action but different chemical structure .…”

Section: Discussionmentioning

confidence: 99%