Etude chez l'homme, par tomographie a emission de positons, du metabolisme et du debit sanguin cerebral dans les epilepsies partielles complexes et dans differents etats de mal

Franck, Georges; Sadzot, Bernard; Salmon, Eric; Maquet, Pierre; Peter, Jonah; Quaglia, L.; Delfiore, Guy; Lamotte, D

doi:10.1016/s0370-4475(86)80048-x

Cited by 12 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most cerebral metabolic activity (80–85 %) is related to propagation of action potentials and restoring post-synaptic ion fluxes primarily related to glutamate, making metabolism a fairly direct measure of neuronal activity [16]. There have only been single case reports demonstrating FDG-PET metabolic changes corresponding to IIC patterns [10, 17–19]. We therefore investigated FDG-PET cerebral metabolism as a candidate biomarker for electrographic SE or electroclinical SE among patients with IIC patterns.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Correlates of the Ictal-Interictal Continuum: FDG-PET During Continuous EEG

et al. 2016

View full text Add to dashboard Cite

Background Ictal-interictal continuum (IIC) continuous EEG (cEEG) patterns including periodic discharges and rhythmic delta activity are associated with poor outcome and in the appropriate clinical context, IIC patterns may represent “electroclinical” status epilepticus (SE). To clarify the significance of IIC patterns and their relationship to “electrographic” SE, we investigated FDG-PET imaging as a complementary metabolic biomarker of SE among patients with IIC patterns. Methods A single-center prospective clinical database was ascertained for patients undergoing FDG-PET during cEEG. Following MRI-PET co-registration, the maximum standardized uptake value in cortical and subcortical regions was compared to contralateral homologous and cerebellar regions. Consensus cEEG review and clinical rating of etiology and treatment response were performed retrospectively with blinding. Electrographic SE was classified as discrete seizures without interictal recovery or >3-Hz rhythmic IIC patterns. Electroclinical SE was classified as IIC patterns with electrographic and clinical response to anticonvulsants; clonic activity; or persistent post-ictal encephalopathy. Results Eighteen hospitalized subjects underwent FDG-PET during contemporaneous IIC patterns attributed to structural lesions (44 %), neuroinflammatory/neuroinfectious disease (39 %), or epilepsy (11 %). FDG-PET hypermetabolism was common (61 %) and predicted electrographic or electroclinical SE (sensitivity 79 % [95 % CI 53–93 %] and specificity 100 % [95 % CI 51–100 %]; p = 0.01). Excluding electrographic SE, hypermetabolism also predicted electroclinical SE (sensitivity 80 % [95 % CI 44–94 %] and specificity 100 % [95 % CI 51–100 %]; p = 0.01). Conclusions In hospitalized patients with IIC EEG patterns, FDG-PET hypermetabolism is common and is a candidate metabolic biomarker of electrographic SE or electroclinical SE.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolic Correlates of the Ictal-Interictal Continuum: FDG-PET During Continuous EEG

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Twenty one of 25 epileptic patients showed an abnormal rCBF pattern during photic stimulation (table 1). For 16 (cases 1-16) of 19 epileptic patients with stable EEG epileptic focus (cases [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], an activation index increase and/or a greater asymmetries was observed in the suspected epileptic focus: one subject (case 13) showed only a rCBF activation in the region corresponding to resting hypoperfusion and epileptic EEG abnormalities, three patients (cases 14,15,16) demonstrated only an asymmetry greater for the epileptic region than the homologous contralateral one and the 12 others showed both an activation and a greater asymmetry in the region of the stable epileptic focus. Moreover eight Table 3 index in the region corresponding to the site of the greater asymmetry.…”

Section: Resultsmentioning

confidence: 99%

Interictal regional cerebral blood flow during non specific activation test in partial epilepsy.

Valmier

Touchon²,

Baldy-Moulinier³

1989

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

SUMMARY In order to investigate, during activation testing, the interictal cortical cerebral blood flows (rCBF) of epileptic patients suffering from complex partial seizures, 40 epileptic patients (divided into "lesional", this is, with abnormal CT findings, and "non lesional", that is, with normal CT findings) were submitted to rCBF measurements with the 133 xenon intravenous technique, at rest and during intermittent light stimulation (ILS). The findings compared with normal volunteers seem to demonstrate that, during ILS, (1) in non lesional patients, the suspected epileptic focus shows a significant rCBF increase (2) in lesional patients, the significant rCBF increases were not in the region of the suspected epileptic focus but in adjacent or in contralateral ones. It was concluded that activation interictal rCBF measurements are more useful than resting ones for the determination of epileptic foci when CT findings are normal and that the nature of the epileptic focus influences markedly the interhemispheric activation pattern.

show abstract

“…Based on these results, one might attribute the distinctive rCBF disturbances associated with the abnormal MR signal to the epileptogenic and/or the lesional nature of the latter. Indeed, focal hypoperfusion and hypometabolism that are closely linked to each other (Kuhl et al, 1980;Bernardi et al, 1983;Yamamoto et al, 1984;Franck et al, 1986) have been proved to be topographically concordant with the epileptogenic area as delineated by stereoelectroencephalography (Engel et al, 1982~;Rowe et al, 1989). On the other hand, the degree of metabolic impairment was also found to correlate with the intensity of neuronal loss in the resected epileptic tissue (Engel et al, 1982~).…”

Section: Discussionmentioning

confidence: 98%

“…In the interictal state, SPECT HMPAO may exhibit focal hypofixation (Biersack et al, 1986;Bajc et al, 1987;Podreka et al, 1987), which reflects decreased regional cerebral blood flow (rCBF) (Lear, 1988). This perfusion disturbance is closely linked to the metabolic impairment demonstrated by positron emission tomography (PET) (Kuhl et al, 1980;Bernardi et al, 1983;Yamamoto e t al., 1984;Franck et al, 1986), and both abnormalities correlate well with data from depth electrode recordings (Engel et al, 1982~;Rowe et al, 1989). MRl, when it does not reveal a specific pathological process such as a tumor or a vascular malformation (Riela et al, 1984;Bergen et al, 1985;Kuzniecky et al, 1987;Rougier et al, 1988), may exhibit a nonspecific high signal intensity on T,-weighted images (T,WIs) concordant with the site of the EEG focus in 18-62% of cases (McLachlan et al, 1985;Kuzniecky et al, 1987;Mauguiere et al, 1989;Convers et al, 1990).…”

mentioning

confidence: 99%

High Signal Intensity on T₂‐ Weighted MRI Correlates with Hypoperfusion in Temporal Lobe Epilepsy

Ryvlin

García-Larrea

Philippon³

et al. 1992

Epilepsia

View full text Add to dashboard Cite

Single-photon emission computed tomography (SPECT) and [99mTc]HMPAO were used to assess the functional significance of nonspecific magnetic resonance imaging (MRI) abnormalities observed in patients with temporal lobe epilepsy and no focal lesion on CT scan. We studied 18 patients whose MRI was normal or showed high signal intensity on T2-weighted images (T2WIs) at the site of the EEG focus in 11 and 7 cases, respectively. EEG was monitored during regional cerebral blood flow (rCBF) study. Lateralized hypoperfusion was present in 7 of 17 interictal (41%) and in one postictal cases; it was located in the temporal lobe on the side of the EEG focus in all, and was significantly more frequent in patients with high signal intensity on T2WI (86%) than in patients with a normal MRI (18%). The degree of temporal perfusion asymmetry measured in each individual was higher in patients whose MRI was abnormal.

show abstract

Etude chez l'homme, par tomographie a emission de positons, du metabolisme et du debit sanguin cerebral dans les epilepsies partielles complexes et dans differents etats de mal

Cited by 12 publications

References 35 publications

Metabolic Correlates of the Ictal-Interictal Continuum: FDG-PET During Continuous EEG

Metabolic Correlates of the Ictal-Interictal Continuum: FDG-PET During Continuous EEG

Interictal regional cerebral blood flow during non specific activation test in partial epilepsy.

High Signal Intensity on T₂‐ Weighted MRI Correlates with Hypoperfusion in Temporal Lobe Epilepsy

Contact Info

Product

Resources

About

Etude chez l'homme, par tomographie a emission de positons, du metabolisme et du debit sanguin cerebral dans les epilepsies partielles complexes et dans differents etats de mal

Cited by 12 publications

References 35 publications

Metabolic Correlates of the Ictal-Interictal Continuum: FDG-PET During Continuous EEG

Metabolic Correlates of the Ictal-Interictal Continuum: FDG-PET During Continuous EEG

Interictal regional cerebral blood flow during non specific activation test in partial epilepsy.

High Signal Intensity on T2‐ Weighted MRI Correlates with Hypoperfusion in Temporal Lobe Epilepsy

Contact Info

Product

Resources

About

High Signal Intensity on T₂‐ Weighted MRI Correlates with Hypoperfusion in Temporal Lobe Epilepsy