Étude des activités anti-inflammatoire, analgésique et antipyrétique des décoctés aqueux des feuilles et des racines de Pterocarpus erinaceus Poir. (Fabaceae)

Ouédraogo, Noufou; Lompo, Marius; Sawadogo, Richard W.; Tibiri, André; Hay, Anne‐Emmanuelle; Koudou, Jean; Dijoux, Marie-Geneviève; Guissou, IP

doi:10.1007/s10298-012-0732-z

Cited by 24 publications

(25 citation statements)

References 17 publications

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“…Il est connu que la fièvre peut être provoquée par des substances exogènes telles les bactéries, endotoxines, les infections microbiennes (Abdulrahman et al, 2010 ;Morabandza et al, 2016). Ces exogènes pyrogènes sont responsables de la production des différents médiateurs pro-inflammatoires qui stimulent la synthèse des prostaglandines (PGs) exerçant leur action au niveau du centre hypothalamique (point d'équilibre thermique) occasionnant ainsi une élévation de ce thermostat (Ouedraogo et al, 2012). L'injection sous-cutanée de la levure de bière induit la fièvre par la synthèse des PGs.…”

Section: Discussionunclassified

“…Cette injection induit une sensation de douleur qui se manifeste chez les cobayes par un mouvement d'étirement des pattes postérieures et de torsion de la musculature dorso-abdominale, appelés crampes abdominales (Kang et al, 2008). L'effet analgésique est apprécié par le dénombrement de ces crampes pendant 30 min après l'injection de l'agent algogène (Ouedraogo et al, 2012 ;Ochieng et al, 2013…”

Section: Evaluation De L'activité Analgésiqueunclassified

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Evaluation de l’activité antipyrétique, analgésique et anti-inflammatoire de l’extrait méthanolique de <i>Vitex congolensis</i> De Wild. & T. Durand

Embeya¹,

Mavungu²

2020

Int. J. Bio. Chem. Sci

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En République Démocratique du Congo, Vitex congolensis De Wild. & T. Durand (Lamiaceae) est une plante médicinale largement utilisée dans le traitement des pathologies à composante inflammatoire. La présente étude a eu pour objectif d’évaluer les activités antipyrétique, analgésique et anti-inflammatoire de l’extrait méthanolique de la poudre d’écorce de racine de cette espèce sur des modèles de pyrexie, algésie et inflammation induites chez les cobayes. L’étude a concerné 24 cobayes de deux sexes répartis en quatre lots de 6 animaux : un lot témoin positif traité avec du diclofenac en intrapéritonéale, un lot témoin négatif ayant reçu soit de l’eau distillée per os soit du sérum physiologique en intrapéritonéale ainsi que deux lots ayant respectivement reçu 100 mg et 300 mg de l’extrait méthanolique de la poudre d’écorce de racines de V. congolensis par kg de poids corporel par voie orale. Les deux doses (100 et 300 mg) de l’extrait méthanolique préviennent de façon significative, le processus inflammatoire comparativement aux lots standard (médicaments de références) et contrôle négatif (eau distillée/sérum physiologique). L’étude a montré que l’extrait méthanolique d’écorces de racine de V. congolensis pourrait être une source potentielle des nouveaux médicaments anti-inflammatoires.Mots clés: antipyrétique, analgésique, anti-inflammatoire, extrait méthanolique, Vitex congolensis De Wild. & T. Durand. English Title: Antipyretic, analgesic and anti-inflammatory activity of the methanolic extract of Vitex congolensis De Wild. & T. DurandIn the Democratic Republic of Congo, Vitex congolensis De Wild. & T. Durand (Lamiaceae) is a medicinal plant widely used in the treatment of pathologies with an inflammatory component. The main objective of this study was to evaluate the antipyretic, analgesic and anti-inflammatory activities of the methanolic extract of the powder of this species on models of pyrexia, algesia and inflammation induced in guinea pigs. The study concerned 24 guinea pigs of both sexes divided into 4 lots of six animals each : a positive control group treated with diclofenac intraperitoneally, a negative control group that received either oral or intraperitoneal (distilled water / physiological saline) ; and two groups respectively receiving 100 mg and 300 mg of the methanolic extract of the root bark powder of V. congolensis per kg of body weight orally. The two doses (100 and 300 mg) of the methanolic extract significantly prevent the inflammatory process compared to standard batches (reference drugs) and negative control (distilled water / physiological saline). The study showed that the methanolic extract of V. congolensis root bark could be a potential source of new anti-inflammatory drugs.Keywords: antipyretic; analgesic, anti-inflammatory, methanolic crude, Vitex congolensis De Wild. & T.Durand.

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Section: Discussionunclassified

Section: Evaluation De L'activité Analgésiqueunclassified

Evaluation de l’activité antipyrétique, analgésique et anti-inflammatoire de l’extrait méthanolique de <i>Vitex congolensis</i> De Wild. & T. Durand

Embeya¹,

Mavungu²

2020

Int. J. Bio. Chem. Sci

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“…A second phase (2-3 h) involves kinins, principally bradykinin, as a mediator increasing vascular permeability and edema formation. The last phase (3-6 h) is due to the release of prostaglandins, arachidonate metabolites, neutrophil migration and release of oxygen free radicals [20,21,22]. The results showed that Crinum scillifolium extracts inhibited significant the formation of the rat paw edema in the early and late phases (Hydroethanolic extract) and late phases (aqueous extract) and the standard anti-inflammatory drug Diclofenac significantly reduced the rat paw edema compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats

Donald¹,

Genevieve²,

Etienne³

et al. 2018

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Aim of study: Inflammation was associated with many diseases in humans. Crinum species have a considerable medicinal reputation as potent folkloric remedies. The main objective of the study was to evaluate the anti-inflammatory activity of aqueous and hydroethanolic extracts of Crinum scillifolium bulbs in in vivo models. Materials and methods: The anti-inflammatory effect of Crinum scillifolium extracts was also evaluated in carrageenan-induced paw edema models and C-reactive protein (CRP) levels was measured. Two doses 100 and 200 mg/kg body weight for each extract, were tested. The results obtained were compared with those of the standard drug (Diclofenac at 25 mg/kg body weight) and those of the control (normal saline). Results: The results showed a highly significant decrease in the edema size (p < 0.01) and significant decrease in CRP values (p < 0.01) compared to control group when the animals were treated with diclofenac at 25 mg/kg, and 200 mg/kg of aqueous and hydroethanolic extracts. Conclusion: The study suggests that the extracts possess enough potential to reduce inflammation on rat model and directs the importance of further research and development of novel anti-inflammatory agents.

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“…They were fed and maintained under standard procedures, with access to water and standard food (Bovin fattening). The mice were with an empty stomach for 17 hours before each experiment 16 .…”

Section: Animalsmentioning

confidence: 99%

Analgesic and anti-inflammatory activity of aqueous extract of Bubonium graveolens

et al. 2020

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Introduction: Bubonium graveolens is used in traditional pharmacopoeia against imbalances of the gastrointestinal tract, cephalic pains, and bronchitis, and as an anti-inflammatory agent. Methods: We have investigated the analgesic and anti-inflammatory activities of the aqueous extract of Bubonium graveolens in male mice of strain NMRI Albinos, weighing between 22 g and 38 g. Acetic acid was used to induce writhes in the mice and inflammation of paw edema. Results: Evaluation of the analgesic activity showed that the aqueous extract at 150 mg/kg of the plant induced a decrease in the number of abdominal cramps caused by 1% acetic acid. The aqueous extract of the plant had an analgesic effect almost equal to that of Diclofenac; in fact, the latter caused a pain inhibition of 49 ± 1.1% while Bubonium graveolens caused a pain inhibition of 49.6 ± 2.1%, at the concentration of 150 mg/kg. Evaluation of the percentage of inhibition showed that the aqueous extract of Bubonium graveolens had a better anti-inflammatory activity compared to Diclofenac sodium during the treatment duration (69.57% — 56.52% at 60 min; 71.43% — 50.00% at 120 min, and 75.00% — 66.67% at 180 min). Conclusion: The results of this research indicate that Bubonium graveolens inhibits inflammation and could explain its effective use in traditional medicine.

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Étude des activités anti-inflammatoire, analgésique et antipyrétique des décoctés aqueux des feuilles et des racines de Pterocarpus erinaceus Poir. (Fabaceae)

Cited by 24 publications

References 17 publications

Evaluation de l’activité antipyrétique, analgésique et anti-inflammatoire de l’extrait méthanolique de <i>Vitex congolensis</i> De Wild. & T. Durand

Evaluation de l’activité antipyrétique, analgésique et anti-inflammatoire de l’extrait méthanolique de <i>Vitex congolensis</i> De Wild. & T. Durand

Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats

Analgesic and anti-inflammatory activity of aqueous extract of Bubonium graveolens

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