Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats

Abstract

Aim of study: Inflammation was associated with many diseases in humans. Crinum species have a considerable medicinal reputation as potent folkloric remedies. The main objective of the study was to evaluate the anti-inflammatory activity of aqueous and hydroethanolic extracts of Crinum scillifolium bulbs in in vivo models. Materials and methods: The anti-inflammatory effect of Crinum scillifolium extracts was also evaluated in carrageenan-induced paw edema models and C-reactive protein (CRP) levels was measured. Two doses 100 and 200 mg/kg body weight for each extract, were tested. The results obtained were compared with those of the standard drug (Diclofenac at 25 mg/kg body weight) and those of the control (normal saline). Results: The results showed a highly significant decrease in the edema size (p < 0.01) and significant decrease in CRP values (p < 0.01) compared to control group when the animals were treated with diclofenac at 25 mg/kg, and 200 mg/kg of aqueous and hydroethanolic extracts. Conclusion: The study suggests that the extracts possess enough potential to reduce inflammation on rat model and directs the importance of further research and development of novel anti-inflammatory agents.

Haematic Potentials of Rhyhchospora corymbosa and Olax subscorpioïdea Extracti in Phenylhydrazine-induced Anaemic Rats

“…They would also present protective activities of veins and capillaries (Macheix and al., 2005). In addition to these compounds, alkaloids have antibiotic, antiparasitic and analgesic activities (Koua and al., 2018) and would also have an effect on the central nervous system (Bruneton and al., 2009). Finally, terpenoids and steroids derived from terpenoids constitute the largest known set of secondary plant metabolites (Yamunadevi and al., 2011).…”

The Impact of the Recipe from Zanthoxylum leprieurii Bark, Harungara madagascariensis Leaves and Xylopia aethiopica Fruits on Nociception and Inflammation in Wistar Rats

“…Indeed, according to Allegra [24] ; Eom [25]; alkaloids are well known for their ability to inhibit pain perception. Furthermore, Koua [26], showed that the presence of flavonoids in Crinum scillifolium extracts would have inhibited acetic acid injection-induced spasms. The presence of these chemical compounds in ZHm extracts would therefore be responsible for its peripheral analgesic activity.…”

“…The decrease in the volume of rat paw edema by ZHm extracts at 400 and 800 mg/kg bw could be explained by the presence of polyphenols in these extracts. These would have acted as substances with antagonistic action on the effects of histamine, serotonin, bradykinin and prostaglandin biosynthesis [26].…”