Étude des activités anti-inflammatoire, analgésique et antipyrétique des décoctés aqueux des feuilles et des racines de Pterocarpus erinaceus Poir. (Fabaceae)

Ouédraogo, Noufou; Lompo, Marius; Sawadogo, Richard W.; Tibiri, André; Hay, Anne‐Emmanuelle; Koudou, Jean; Dijoux, Marie-Geneviève; Guissou, IP

doi:10.1007/s10298-012-0682-x

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…These values are similar to those obtained for indomethacin. The appearance of abdominal torsions under the effect of acetic acid engages the effect of local peritoneal receptors [36] as well as the release of mediators such as prostaglandins and cytokines [35]. The analgesic effect of the extract, leaves us to suppose that the biomolecules contained in the female cones of Ephedra alata could inhibit the release of chemical mediators, as was also reported by Perz-Guerro C et al [38].…”

Section: Variations In the Activity Of Tissue Antioxidant Enzymesmentioning

confidence: 63%

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

Chouikh¹

2020

FARMACIA

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The aim of this study is the estimation of the antioxidant, analgesic and hypolipidemic effects and the chromatographic analysis of the extract of female cones of Ephedra alata which is growing in South East Algeria. The extract of E. alata showed better inhibition of DPPH• radical, the highest reductive activity and gave the best protection of erythrocytes. The HPLC analyses has identified eight phenolic compounds: gallic acid, chlorogenic acid, vanillic acid, vanillin, p-coumaric acid, rutin, naringenin and quercetin. The results of the protective effect of hyperlipidaemia caused by Triton X-100 showed that there are noticeable changes in the biochemical and lipid parameters, also for the parameters of oxidative stress in the group exposed to Triton X-100. Also, the treatment with the methanol extract of E. alata yielded similar results to the control batches by normalizing and decreasing the biochemical, stress and lipid parameters. The histological study confirmed the biochemical results. According to the results of the analgesic activity, the extract of E. alata induced a significant decrease in abdominal writhings compared to the control group and the values obtained are very close to those obtained with indomethacin. Rezumat Scopul acestui studiu a fost evaluarea efectelor antioxidante, analgezice, hipolipemiante și analiza cromatografică a extractului de conuri femele de Ephedra alata, din sud-estul Algeriei. Extractul de E. alata a arătat o inhibiție mai bună a radicalului DPPH •, cea mai ridicată activitate reducătoare și a oferit cea mai bună protecție asupra eritrocitelor. Analizele HPLC au identificat opt compuși fenolici: acid galic, acid clorogenic, acid vanilic, vanilină, acid p-cumaric, rutină, naringenină și quercetină. Rezultatele efectului protector asupra hiperlipemiei cauzate de Triton X-100 au arătat că există modificări vizibile ale parametrilor biochimici și lipidici, de asemenea, pentru parametrii stresului oxidativ din grupul expus la Triton X-100. De asemenea, tratamentul cu extract metanolic de E. alata a scăzut parametrii biochimici, stresul oxidativ și parametrii lipidici. Studiul histologic a confirmat rezultatele biochimice. Acțiunea analgezică a extractului de E. alata a indus o scădere semnificativă a contorsiunilor comparativ cu grupul martor și valorile obținute sunt foarte apropiate de cele obținute în cazul administrării de indometacin.

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Section: Variations In the Activity Of Tissue Antioxidant Enzymesmentioning

confidence: 63%

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

Chouikh¹

2020

FARMACIA

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“…The appearance of abdominal torsions under the effect of acetic acid engages the effect of local peritoneal receptors [22] as well as the release of mediators such as prostaglandins and cytokines [23]. The analgesic effect of the extract of C. comosum supposes that the biomolecules contained in this plant could inhibit the release of chemical mediators, especially the tannins has been reported as an effective analgesic constituent [24].…”

Section: Analgesic Activitymentioning

confidence: 99%

The influence of extraction method on the composition and analgesic activity of Calligonum comosum phenolic extracts

Chouikh¹,

Rebiai²

2020

Ovidius University Annals of Chemistry

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The aim of this study was to evaluate the analgesic activity and the effect of extraction methods (ultra-sound: UM and maceration: MM) and solvents (ethanol: EtOH and methanol: MeOH) on the composition of phenolic extracts from Calligonum comosum. The results obtained by HPLC analysis demonstrated that the ethanol extracts have shown the highest content of total phenolic and flavonoid compounds. Also, the presence of most known phenolic compounds has been identified in all extracts, especially in the MeOH UM extract. The HPLC analysis showed the presence of ascorbic acid in methanol extracts and caffeic acid in ethanol extracts, and the maceration method shows a high concentration of phenolic compounds, the vanillin was detected in MeOH UM and the appearance of chlorogenic acid in UM extracts, finally the emergence of gallic acid, quercetin and rutin in some extracts. According to the results of the analgesic power, the methanolic extract of the maceration method induces a significant decrease in abdominal cramps compared to the control group and the values obtained are very close from those obtained with the standard anti-inflammatory drug (indomethacin). This result confirmed the beneficial effect of this Saharan plant.

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“…In fact, free radicals such as reactive oxygen species (ROS) damage the functionality of the cell membrane by peroxidized lipids [33]. Lipid peroxidation has been reported to complicate the inflammatory process [34].…”

Section: +mentioning

confidence: 99%

“…The secondary metabolites like phenolics and flavonoids from plants have been reported to be potent free radical scavengers and they are found in all parts of plants [35]. [33] also report that antioxidant substances can prevent and delay the oxidation of lipids by acting on ROS reduction and the production of other free radicals. Thus, the inhibition lipid peroxidation contributes to the protection of the cell membrane against free radicals.…”

Section: +mentioning

confidence: 99%

Phytochemical, Antioxidant and Anti-Inflammatory Effects of Extracts from Ampelocissus africana (Lour) Merr (Vitaceae) Rhizomes

Kabré

Ouédraogo

Coulibaly

et al. 2020

JPRI

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Aims: To determine the phytochemical composition and evaluate the antioxidant and anti-inflammatory properties of methanolic and aqueous extracts from Ampelocissus africana (Lour) Merr rhizomes. Study Design: Phytochemical content and screening, in vitro antioxidant and anti-inflammatory assays. Place and Duration of Study: Department of Traditional Pharmacopoeia and Pharmacy (MEPHATRA / PH) of the Institute for Research in Health Sciences (IRSS) and Laboratory of Applied Biochemistry and Chemistry (LABIOCA), University Joseph KI-ZERBO in Ouagadougou between April and August 2020. Methodology: The antioxidant activity of both extracts of the plant was assessed using DPPH radical scavenging, ABTS+ radical cation decolorization, ferric ion reduction and lipid peroxidation inhibition in rat liver assays. The anti-inflammatory activities in vitro were measured on the ability of the extract to inhibit the activity of enzymes such as 15-lipoxygenase, phospholipase A2 (PLA2) and cyclooxygenases (COX-1 and COX-2). Results: This study revealed that the total phenolic contents of the extracts varied from 471.79 ± 1.71 mg GAE/g to 173.88 ± 1.71 mg GAE/g for methanolic and aqueous extract respectively. The extracts were also rich in flavonoids and tannins. The methanolic extract possessed better antioxidant activity with an IC50 of 2.32 ± 0.18 µg/ml for the ABTS, 1.71 ± 0.05 µg/mL for the DPPH, a reducing power agent of 87.44 ± 0.5 mmol AAE /100 g and a percentage inhibition of lipid peroxidation of 52.21%. The methanolic and aqueous extract of A. africana has an inhibitory action on activity of lipoxygenase with IC50 values of 26.09 ± 1.83 μg/mL to 34.32 ± 1.60 μg/mL, respectively. The methanolic extract caused COX-1 inhibition of 36.07%, COX-2 inhibition of 38.31% and PLA2 inhibition of 26.9%. Conclusion: These results showed that the methanolic and aqueous extract from the rhizomes of Ampelocissus africana possessed antioxidant power, inhibitor effect against proinflammatory enzymes.

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Étude des activités anti-inflammatoire, analgésique et antipyrétique des décoctés aqueux des feuilles et des racines de Pterocarpus erinaceus Poir. (Fabaceae)

Cited by 12 publications

References 16 publications

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

Phytochemical Profile, Antioxidant, Analgesic and Hypolipidaemic Effects of Ephedra Alata Decne. Female Cones Extract

The influence of extraction method on the composition and analgesic activity of Calligonum comosum phenolic extracts

Phytochemical, Antioxidant and Anti-Inflammatory Effects of Extracts from Ampelocissus africana (Lour) Merr (Vitaceae) Rhizomes

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