Etude du mecanisme de l'hydrolyse alcaline des N-methyl acetanilides au moyen des effets de milieu

Kinetics and mechanism of hydrolysis of insecticidal O-(methylcarbamoyl)oximes

“…As a matter of fact, the values observed for the ZV,ZV-dimethyl derivatives are consistent with those reported for reactions where hydroxide ion attack at a carbonyl group is rate determining. Thus, Gani and Viout (1976) measured an isotope effect of 0.69 for iV-methyl-p-nitroacetanilides.…”

Reactivity of acetanilides in the alkaline hydrolysis reaction: theory vs. experiment

“…The amide hydrolysis has been the subject of numerous experimental [26][27][28][29][30][31][32][33][34][35][36] and theoretical studies because it is regarded as a model process for the cleavage of peptide bonds [58]. In a recent combined kinetic and computational study [57] we showed that the rate of the alkaline hydrolysis of three secondary amides -Nmethylbenzamide, N-methylacetamide and acetanilide -is governed by the second stage of the reaction.…”