Abstract:On the high plains of Setif, the old inhabitants have built a real knowledge of medicinal plants properties. Traditional knowledge about plants and their properties are still fairly common. Our scientific motivation stems from the absence of any flora and ethnobotanical study in this area. During different field campaigns, we identified 93 medicinal species belonging to 32 botanical families. This number reflects the wealth of medicinal plants that are still traditionally used. To gather as much information on the use of plants, a series of ethnobotanical surveys were conducted in the field during periods of picking from villagers, herbalists and traditional healers. According to those surveyed, the fresh leaves and seeds are considered the most popular and common parts that can address several diseases where oral and dermal administration are recommended. The most used plants are: Artemisia herba-alba, Argyrolobium saharae, Gymnosporia senegalensis, Ormenis africana, Pallenis spinosa, Thymus ciliatus, Pistacia atlantica, Paronychia arabica, Globularia alypum, Ajuga iva, Peganum harmala, Ruta chalepensis, Tapsia garganica, Pituranthos scoparius. Djebel Zdimm offers floristic diversity and a sizeable traditional therapeutic knowledge. The safeguarding and preservation of this ancestral heritage is one of our objectives in this semi-arid steppe.