Eugenol triggers CD11b+Gr1+myeloid-derived suppressor cell apoptosisviaendogenous apoptosis pathway

Ding, Ying; Yang, Zhihong; Zhang, Wensheng; Xu, Yuwei; Wang, Yuanyuan; Hu, Minghua; Ma, Fangli; Long, Hu; Ning, Tao; Qin, Zhihai

doi:10.1039/c7ra13499a

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…On mouse LPS-and pokeweed mitogenactivated splenocytes, eugenol at 100 and 1,000 μg/mL was found to suppress IFN-γ activity and B cell proliferation through T celldependent and independent pathways (Saraphanchoiwitthayaet et al, 2019). Contrarily, eugenol was found to inhibit myeloid-derived suppressor cells (immune inhibitors) in spleen cells from tumor-bearing mice, resulting in increased immune response (Ding et al, 2018). Additionally in mice with experimental visceral leishmaniasis, eugenol oleate was found to activate the immune system to clear the parasite (Raja et al, 2020).…”

Section: Immune-enhancing Propertiesmentioning

confidence: 99%

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

Garnier¹,

Shahidi²

2021

Journal of Food Bioactives

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Spices and herbs have been used in traditional medicine for centuries, with research starting to accumulate on their beneficial properties. Of these properties, the immune-enhancing and anti-inflammatory capabilities of many spices and herbs have led to promising results. The current review article aims to explore the current research of several spices and herbs as immune-enhancers and anti-inflammatory agents. The spices and herbs examined are African potato (Hypoxis hemerocallidea), allspice (Pimenta dioica), basil (Ocimum basilicum), black pepper (Piper nigrum), chili powders (Capsicum species), clove (Syzygium aromaticum), Devil’s claw (Harpagophytem procumbens), fenugreek (Trigonella foenum-graecum), ginger (Zingiber officinale), lavender (Lavandula angustifolia), oregano (Origanum vulgare), rooibos (Aspalathus linearis), rosemary/sage (Salvia rosmarinus/officinalis), saffron (Crocus sativus), South African geranium (Pelargonium sidoides), and turmeric (Curcuma longa). All the spices and herbs exhibited immune-enhancing or immunomodulatory and anti-inflammatory capabilities through various processes. Rooibos and oregano had the most contradictory results, with some studies finding pro-inflammatory properties, especially at high doses regarding oregano. Turmeric had the most extensive research with positive results.

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Section: Immune-enhancing Propertiesmentioning

confidence: 99%

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

Garnier¹,

Shahidi²

2021

Journal of Food Bioactives

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“…This protein has a pivotal role in cellular survival, cellular proliferation and activation. In leukemic condition BCL2 plays a very important role in the survival and progression of the disease by suppressing the drug induced apoptosis [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Withanolide D of Ashwagandha improves Apoptosis in the Bone Marrow of Leukemic Murine Model

Sayantan¹

2021

J Biomed Res Environ Sci

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Background: Leukemia is one of the most occurring haematological pathologies in the world which develops due to the impairment in the hematopoietic machinery. Cellular death via apoptosis is severely impaired in this pathophysiological condition and leads to the progression of the disease. Objective: We have tried to unearth the efficacy of Withanolide D, a steroidal lactone derived from Withania somnifera or Ashwagandha on some of the apoptotic machinery components, i.e. TERT, BCL2 and PUMA in the experimental leukemic mice. Materials and Methods: LD50 and EC50 values of Withanolide D were estimated. Three groups of animals were taken for experimental purpose i.e. Group I = Leukemic, (L); Group II = Control, (C); Group III = Leukemic treated with Withanolide D, (L + WD). Group III received Withanolide D via oral route and other two groups received equal volume of distilled water. Various cytological, immunofluorescence and flow cytometric studies were taken into consideration post administration. Result: Leukemic group showed increased cellular proliferation and decreased cellular death as compared to control. Post Withanolide D administration TERT, BCL2 and PUMA expression started to shift towards normal status. This shift in the expressional values of increased apoptosis rate and decreased cellular proliferation revealed by cytological, immunofluorescence studies and flow cytometric investigations. Conclusion: As Withanolide D decreased the suppression of apoptosis and impaired the progression of the disease, so, we can conclude that Withanolide D of Ashwagandha may hold a promise towards a new therapeutic strategy in leukemia.

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Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress

Zeng

Du²,

Zhang

et al. 2020

Archives of Biochemistry and Biophysics

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Eugenol triggers CD11b⁺Gr1⁺myeloid-derived suppressor cell apoptosisviaendogenous apoptosis pathway

Abstract: To study the effect and underlying molecular mechanism of eugenol on CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs).

Cited by 4 publications

References 36 publications

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

Withanolide D of Ashwagandha improves Apoptosis in the Bone Marrow of Leukemic Murine Model

Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress

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