Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice

Park, Sang Hyun; Ko, Sung Kwon; Chung, Sung Hyun

doi:10.1016/j.jep.2005.06.041

Cited by 87 publications

(54 citation statements)

References 30 publications

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“…The Euonymus alatus has long been used as a crude drug for gynecological diseases including metritis. Recently, it has been reported that Euonymus alatus is effective for rheumatoid arthritis, diabetes, hyperglycemia and chronic nephropathy (Chung et al, 2002;Park et al, 2005;Zhang and Zhao, 2005). Base on these considerations, we presumed that EEA has an anti-inflammatory potential, at least in part, due to its direct inhibition of IKK␤ activity.…”

Section: Discussionmentioning

confidence: 99%

“…Rutin, quercetin, kaempferol, 5-caffeylquinic acid and other phenolic compounds have been isolated from Euonymus alatus (Jin et al, 2005;Fang et al, 2008;Zhang et al, 2009). Recently, many researchers have reported that Euonymus alatus exhibited several pharmacological effects including antihyperglycaemic and immune-modulating activity, and is also effective in inflammatory diseases such as rheumatoid arthritis (Chung et al, 2002;Park et al, 2005;Zhang and Zhao, 2005). Chung et al (2002) have showed that Euonymus alatus extract regulates a production of nitric oxide and tumor necrosis factor-␣ in recombinant interferon-␥-primed macrophages.…”

Section: Introductionmentioning

confidence: 99%

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Euonymus alatus extract attenuates LPS-induced NF-κB activation via IKKβ inhibition in RAW 264.7 cells

Mun

Seo

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Euonymus alatus extract attenuates LPS-induced NF-κB activation via IKKβ inhibition in RAW 264.7 cells

Mun

Seo

et al. 2011

Journal of Ethnopharmacology

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“…17,18) Briefly, a portion (100 mg) of liver tissue was homogenized in phosphate buffer saline (pH 7.4, 1 ml). The homogenate (0.2 ml) was extracted with isopropyl alcohol (1 ml), and the extract was analyzed using a Triglyceride E-Test to determine liver triglyceride content.…”

Section: Methodsmentioning

confidence: 99%

Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice

Tajima

Ikarashi

Okaniwa

et al. 2013

Biological & Pharmaceutical Bulletin

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It has been recently reported that the consumption of a high-fat diet during pregnancy exerts various effects on fetuses and newborn mice. The purpose of this study was to determine the effects of a high-fat diet during pregnancy on the expression of cytochrome P450 (CYP) in the livers of offspring. Mouse dams were fed a high-fat diet during pregnancy from the time of conception. After their birth, the newborn mice were fed a normal diet until 12 weeks of age. In the livers of the infant male mice that consumed a high-fat diet, the protein expression of CYP3A and CYP2C was decreased, and the protein expression of CYP1A and CYP2E was increased at 6 and 12 weeks of age. However, almost no changes were observed in the CYP proteins at 6 and 12 weeks of age in the livers of the infant female mice that consumed a high-fat diet. The amount of pregnane X receptor (PXR) translocated into the nucleus was reduced in the livers of infant male mice that consumed a high-fat diet. However, there was neither an increase in tumor necrosis factor-α or interleukin-1β nor a decrease in lithocholic acid. These data suggested that CYP3A and CYP2C might decrease as a result of the decrease in the amount of nuclear PXR in infant male mice that consumed a high-fat diet. The results of this study suggested that the consumption of a high-fat diet by pregnant mothers may be one explanation for individual differences in pharmacokinetics.Key words high-fat diet; cytochrome P450; pregnane X receptor; pharmacokinetics Studies have reported that consumption of a high-fat diet during pregnancy exerts various effects on offspring.1-4) For example, rats born to mothers that were given a high-fat diet during pregnancy showed an increased number of galaninproducing brain cells (galanin is an orexigenic peptide in the brain), which leads to obesity at 10 weeks of age.1) Additionally, the level of brain-derived neurotrophic factor in the brain decreases, which can lead to the development of neurodegenerative diseases such as Alzheimer's disease. 4)Cytochrome P450 (CYP) is major drug-metabolizing enzyme that is known to metabolize approximately 70% of the drugs used in clinical practice.5) The role of the CYP3A subfamily is important because approximately 50% of all drugs are metabolized by CYP3A. 5) In humans, the expression level of CYP3A accounts for more than 30% and 70% of total CYP protein expression in the liver and the intestine, respectively. 6)Therefore, changes in CYP3A expression and activity exert significant effects on drug therapy. 7-9) It has been reported that there are sex differences in the expression of CYP. For example, in mice, CYP2D9 and CYP4A12 are specifically expressed in males, and CYP2A4, CYP2B9, CYP3A41, and CYP3A44 are specifically expressed in females. 10-12)There have been many reports suggesting that the consumption of a high-fat diet differentially affects the expression and activity of CYP. 13,14) It has also been reported that obesity in mothers affects the expression of CYP1A1 in fetuses. 15) We have demonstrated th...

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“…[37] On the other hand, liver triglyceride and cholesterol content were measured as described previously. [38,39] Briefly, a portion (100 mg) of liver tissue was homogenized in phosphate buffer saline (pH 7.4, 1 ml). The homogenate (0.2 ml) was extracted with isopropyl alcohol (1 ml), and the extract was analyzed using a Triglyceride E-Test (Wako Pure Chemical Industries) to determine liver triglyceride content.…”

Section: Blood Sampling and Plasma Assaymentioning

confidence: 99%

Anti-obesity, antiatherogenic, anti-diabetic and antioxidant activities of J. montana ethanolic formulation in obese diabetic rats fed high-fat diet

Hussein

2011

Free Radicals and Antioxidants

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Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice

Cited by 87 publications

References 30 publications

Euonymus alatus extract attenuates LPS-induced NF-κB activation via IKKβ inhibition in RAW 264.7 cells

Euonymus alatus extract attenuates LPS-induced NF-κB activation via IKKβ inhibition in RAW 264.7 cells

Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice

Anti-obesity, antiatherogenic, anti-diabetic and antioxidant activities of J. montana ethanolic formulation in obese diabetic rats fed high-fat diet

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