Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells

Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells

“…Recently Choi et al (2009) has reported the novel antitumor, cytotoxic activity of Eupatilin through robust induction of apoptosis in human gastric carcinoma AGS cells complementing the previous findings by Kim at al. (2005b) and Lee et al (2008).…”

“…For example, Eupatilin induced gastric carcinoma AGS cells at G1 phase (Choi et al, 2009). The result of Eupatilin in inducting cell cycle arrest at G2/M phase is also consistent with other studies that some other flavonoid compounds arrest cell cycle at G2/M phase (Auyeung and Ko, 2010;Priyadarsini et al, 2008).…”

DA-9601 suppresses 2, 4-dinitrochlorobenzene and dust mite extract-induced atopic dermatitis-like skin lesions

“…Eupatilin is known to posses various biological effect such as anti-oxidant, anti-inflammation, anti-tumor, and anti-gastritis. The molecular target of eupatilin was revealed as NF-κB [14,[27][28][29]. In the present report, we clearly showed the effect of DA-9601 on the AD; however, the molecular target of this effect is still unknown.…”

Eupatilin inhibits lipopolysaccharide-induced expression of inflammatory mediators in macrophages

“…The herb Artemisia asiatica Nakai is a traditional oriental medicine that has been used for the treatment of diseases such as inflammation, microbial infection, and cancer (Choi et al, 2009;Song et al, 2008). Following such use, a novel anti-peptic formulation from ethanol extracts of A. asiatica, namely, DA-9601 (Stillen TM ), has been developed to treat patients with gastric mucosal ulcers and is now commercially available in South Korea and other Asian countries.…”