Eupatorium lindleyanum DC. sesquiterpenes fraction attenuates lipopolysaccharide-induced acute lung injury in mice

Chu, Chunjun; Ren, Huiling; Xu, Nuo; Xia, Long; Chen, Daofeng; Zhang, Jian

doi:10.1016/j.jep.2016.03.022

Cited by 18 publications

(12 citation statements)

References 29 publications

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“…Furthermore, activated neutrophils act as signaling indicators to promote inflammatory response and enhance the production of additional cytokines in local and/or systemic levels [21]. MPO is involved in the microbicidal activity of neutrophils [22], and its activity reflects the activation and recruitment of neutrophils into lung [23]. As reported by others [24] and our present study, LPS caused ALI-like immune abnormality, which was evidenced by increased MPO activity and neutrophil counts.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

Hsia

Yin

2016

Nutrients

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The effects of S-ethyl cysteine (SEC) and S-methyl cysteine (SMC) on lipopolysaccharide (LPS)-induced acute lung injury in mice were examined. Eight hours after LPS challenge, SEC or SMC was supplied in drinking water at 0.5% or 1% for 3 days. LPS increased lung myeloperoxidase activity, neutrophil counts and edema. SEC or SMC post-intake attenuated these events. SEC or SMC suppressed LPS-induced lung expression of cyclooxygenase-2, nuclear factor-κB and mitogen-activated protein kinase, and lowered the generation of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and prostaglandin E2. LPS enhanced the expression of p47phox, gp91phox, Bax and cleaved caspase-3, and increased the production of reactive oxygen species in the lung. SEC or SMC post-intake reversed these alterations. These findings suggest that these agents could protect the lung through their anti-inflammatory, anti-oxidative and anti-apoptotic activities.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

Hsia

Yin

2016

Nutrients

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“…Significant (for IL-1α and IL-1β) and moderate (for TNF-α) downregulation of cytokines after LPS challenge was reported for methanol, ethanol, and dichloromethane extracts of E. perfoliatum having eupafolin and a dimeric guaianolide as probable responsible compounds (Maas et al, 2011), the sesquiterpene fraction of E. lindleyanum (Chu et al, 2016), and 2-hydroxyeupatolide, a sesquiterpene lactone, widely found in the genus Eupatorium (Ke et al, 2017).…”

Section: Effects Of E Cannabinum Extracts On Cytokine Production In mentioning

confidence: 97%

Evaluation of antiproliferative and protective effects of Eupatorium cannabinum L. extracts

Grigore¹,

Neagu²,

Dobre³

et al. 2018

Turk J Biol

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Eupatorium cannabinum L. (Asteraceae) has been used for a long time for medicinal purposes due to its various pharmacological effects and richness in active compounds such as phenolics, sesquiterpenes, pyrrolizidine alkaloids, and polysaccharides. Despite the high content of compounds that have important roles in medicinal plants, there are still limited literature data regarding this valuable species. The plant was fractioned using chloroform (EC) and distilled water (EA) and HPLC analysis revealed the presence of eupatorin, eupatilin, and quercetin in EC and caffeic acid and rutin in EA. The antiproliferative potential on BT-20, HepG2, Caco-2, and Jurkat cancer cell lines was assessed by MTS test. Jurkat cells were more sensitive to both extracts (IC 50 of 7.35 ± 0.35 for EC and 13.77 ± 2.16 µg/mL for EA), while the other lines were susceptible only to EC (IC 50 88.27 ± 1.34 on Caco-2 cells and over 100 µg/mL on BT-20 and HepG2 cells) after 24 h of exposure. In an LPS-induced damage mouse model of endotoxemia, we showed that preventive administration increases the survival times of mice and leads to inhibition of proinflammatory cytokines. Both polar and nonpolar compounds are involved in exerting these effects, but further analytical studies are needed to identify the key responsible compounds and their biochemical pathways.

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“…Ia (about 34 g) was further fractionated on a silica gel column (800 g, 300-400 mesh, 7.5 × 60 cm), and eluted with CH 2 Cl 2 -MeOH 100 : 1, 95 : 1, 90 : 1, 85 : 1 (each 4 L, v/v) to obtain four subfractions (SFr. a 1a 4 13 C-NMR (CDCl 3 , 100 MHz) (for spectral data, see ▶ Table 1).…”

Section: Extraction and Isolationmentioning

confidence: 99%

“…Several types of compounds have previously been obtained from E. lindleyanum, including sesquiterpenes [2][3][4][5][6][7], diterpenoids, triterpenoids, volatile oil, flavonoids, alkaloids, esters, and coumarins [8,9]. Pharmacological studies of the crude extract and constituents of E. lindleyanum revealed a variety of activities, including antihyperlipidemic [10], antioxidant [11], anticarcinogenic [12], and anti-inflammatory effects [13]. As part of our ongoing research program aimed at discovering plant-derived anti-inflammatory constituents, we found that the sesquiterpenes fraction (SQT) isolated by resin adsorbent chromatography from a water extract of E. lind-leyanum showed a strong inhibitory effect on mouse ear edema induced by xylene.…”

Section: Introductionmentioning

confidence: 99%

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Potential Anti-inflammatory Sesquiterpene Lactones from Eupatorium lindleyanum

et al. 2017

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has traditionally been used as folk medicine in Asian countries for its therapeutic effects on tracheitis and tonsillitis. Investigation of the anti-inflammatory active constituents from led to the isolation of two novel sesquiterpene lactones, named eupalinolide L (1: ) and eupalinolide M (2: ), and seven known sesquiterpene lactones (3: -9: ). The structures and configurations of the new compounds were determined on the basis of spectroscopic analysis, especially 2D NMR techniques. experiments showed that the sesquiterpenes fraction significantly reduced mouse ear edema induced by xylene (18.6%, p < 0.05). In assays, compounds 1: -9: showed excellent anti-inflammatory activities, as they lowered TNF- and IL-6 levels in lipopolysaccharide-stimulated murine macrophage RAW 264.7 cells (p < 0.001). The above results suggest that the sesquiterpene lactones from can be developed as novel potential natural anti-inflammatory agents.

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Eupatorium lindleyanum DC. sesquiterpenes fraction attenuates lipopolysaccharide-induced acute lung injury in mice

Abstract: These results showed that EUP-SQT significantly attenuated LPS-induced ALI via reducing productions of pro-inflammatory mediators and decreasing the level of complement, indicating it as a potential therapeutic agent for ALI.

Cited by 18 publications

References 29 publications

RETRACTED: Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

RETRACTED: Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice

Evaluation of antiproliferative and protective effects of Eupatorium cannabinum L. extracts

Potential Anti-inflammatory Sesquiterpene Lactones from Eupatorium lindleyanum

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