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These results showed that EUP-SQT significantly attenuated LPS-induced ALI via reducing productions of pro-inflammatory mediators and decreasing the level of complement, indicating it as a potential therapeutic agent for ALI.

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In recent years, in order to increase the capacity and scalability of intra-datacenter (DC) transmission, the optical frequency comb (OFC) source has been considered promising to replace discrete lasers, aiming to reduce the cost of wavelength division multiplexing (WDM) transmission within DC. In this paper, an OFC based coherent architecture is proposed. An OFC, in the receiver side, is split by a splitter with a uniform power ratio and separately used as local oscillators (LOs) to detect the demultiplexed signals. The signal spectrum is copied onto every tone of the LO-OFC, and a large frequency offset (FO) tolerance is achieved. In addition, the required ADC sampling rate is the same as a system without FO. Extensive simulations are conducted. In the simulated coherent WDM transmission system, a 3-tone-OFC is used to provide 3 carriers, and an 11-tone-OFC is split and used to provide LO-OFCs. For a 64GBd polarization multiplexing 16 quadrature amplitude modulation (PM-16QAM) WDM transmission, the tolerances of FO are up to about ±0.3THz and ±0.374THz for the 1st/3rd signal, and the 2nd signal, respectively, below the pre-forward error correction (FEC) bit error rate (BER) level of 1.25×10−2. Moreover, the maximum tolerance of FO linearly increases with the number of effective tones in LO-OFC. Further, extensive experiments with back-to-back connection are conducted to verify the performance. The tolerance of FO is up to >36 GHz for 36GBd PM-16QAM transmission with a 3-tone-LO-OFC below the BER level of 1.25×10−2. The proposed OFC based coherent architecture is a promising solution for intra-DC interconnections with a large FO.