Euphorbia-Derived Natural Products with Potential for Use in Health Maintenance

Salehi, Bahare; Vitalini, Sara; Antolak, Hubert; Pawlikowska, Ewelina; Kręgiel, Dorota; Sharifi‐Rad, Javad; Oyeleye, Sunday I.; Ademiluyi, Adedayo O.; Czopek, Katarzyna; Staniak, M.; Custódio, Luísa; Coy-Barrera, Ericsson; Segura‐Carretero, Antonio; Cádiz-Gurrea, María de la Luz; Capasso, Raffaele; Cho, William C.; Seca, Ana M. L.

doi:10.3390/biom9080337

Cited by 88 publications

(107 citation statements)

References 95 publications

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“…Their successes in traditional medicine usage have been attributed to a wide variety of chemical compositions of its members, such as essential oils, oxygenated sesquiterpenes, sesquiterpenes hydrocarbons [ 4 ], as well as the macrocyclic diterpenoids [ 3 ]. As a result, these chemical constituents are now providing lead compounds for drug discovery because of their therapeutic applications, such as cytotoxic, antitumor, antiviral properties, multi-drug-resistance-reversing, and anti-inflammatory activities as well as their great structural diversity, resulting from various polycyclic and macrocyclic skeletons, including but not limited to jatrophane, ingenane, daphnane, tigliane, lathyrane [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, several reviews on Euphorbia species have mainly reported their pharmacological activities [ 13 ], ethnomedicinal usage [ 14 ], and the structural diversity of isolated diterpenoids [ 3 , 15 ] as well as essential oils [ 4 ]. Hence, in order to promote more targeted future research of this species, consolidation of scientific reports/evidence of their ethnomedicinal uses, the chemical constituents, and the identification of possible knowledge gaps need to be addressed.…”

Section: Introductionmentioning

confidence: 99%

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A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species

et al. 2020

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The genus Euphorbia is one of the largest genera in the spurge family, with diversity in range, distribution, and morphology. The plant species in this genus are widely used in traditional medicine for the treatment of diseases, ranging from respirational infections, body and skin irritations, digestion complaints, inflammatory infections, body pain, microbial illness, snake or scorpion bites, pregnancy, as well as sensory disorders. Their successes have been attributed to the presence of diverse phytochemicals like polycyclic and macrocyclic diterpenes with various pharmacological properties. As a result, Euphorbia diterpenes are of interest to chemists and biochemists with regard to drug discovery from natural products due to their diverse therapeutic applications as well as their great structural diversity. Other chemical constituents such as triterpenoids have also been reported to possess various pharmacological properties, thus supporting the traditional uses of the Euphorbia species. These triterpenoids can provide potential leads that can be developed into pharmaceutical compounds for a wide range of medicinal applications. However, there are scattered scientific reports about the anticancer activities of these constituents. Harnessing such information could provide a database of bioactive pharmacopeia or targeted scaffolds for drug discovery. Therefore, this review presents an updated and comprehensive summary of the ethnomedicinal uses, phytochemistry, and the anticancer activities of the triterpenoids of Euphorbia species. Most of the reported triterpenoids in this review belong to tirucallane, cycloartanes, lupane, oleanane, ursane, and taraxane subclass. Their anticancer activities varied distinctly with the majority of them exhibiting significant cytotoxic and anticancer activities in vitro. It is, therefore, envisaged that the report on Euphorbia triterpenoids with interesting anticancer activities will form a database of potential leads or scaffolds that could be advanced into the clinical trials with regard to drug discovery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species

et al. 2020

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“…[5][6][7][8][9][10][11][12] In addition, essential oils (EOs) from Euphorbia species have been documented to contain more than 80 phytochemicals with the presence of mostly sesquiterpenes hydrocarbons and oxygenated sesquiterpenes, while their extracts consist of secondary metabolites such as diterpenes, sesquiterpenes, sterols and flavonoids as well as other polyphenols. 13 Several bioactive constituents isolated from Euphorbia species have also been investigated for their antibacterial, antiradical and antitumor activities. [14][15][16][17][18] Indeed, EOs are in general greatly acknowledged to exhibit a wide range of therapeutic activities.…”

Section: Introductionmentioning

confidence: 99%

Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus

Sinan

Etienne

Stefanucci

et al. 2020

Flavour & Fragrance J

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Several studies demonstrated the wide pharmacological properties of extracts and essential oils (EOs) prepared from Euphorbia species. In the present study, the chemical composition and biological activities of EOs from three different Euphorbia species were evaluated using in vitro methods. A total of 29, 33 and 42 constituents were identified in the EOs of E hirta, E convolvuloides and E heterophylla, respectively. The EOs exhibited in vitro radical scavenging potential in the ABTS assay (2.89‐21.50 mg/g). Additionally, an inhibitory effect on acetylcholinesterase (4.23‐5.12 mg/g) was detected. Besides, remarkable tyrosinase inhibition was reported by the EOs (95.24‐113.74 mg/g). Molecular docking was also performed to elucidate the binding interactions between selected EO components and enzymes. Phytol and geranyl‐(E)‐acetone had a good binding with tyrosinase in the molecular docking. This study highlighted the promising pharmacological profiles of these EOs as natural sources of antioxidants as well as cholinesterase and tyrosinase inhibitors that could be further explored in the management of human ailments in food and pharmaceutical industries.

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“…Paguigan & Chichioco-Hernandez (2014) reported that E. hirta had the highest inhibitory activity (48.5%) and this plant may contain new 15-LO inhibitors. Moreover, Salehi et al (2019) presented the Euphorbia genus were found numerous phytochemicals, which showed medicinal properties on abundant human diseases such as anti-inflammation, anticancer and antimicrobial. Moreover, E. hirta is an important medicinal source and its active substances revealed wide-ranging pharmacological capacities viz.…”

Section: Effect Of Aqueous Extracts From Thai Weeds On Enzymatic Actimentioning

confidence: 99%

Performance of Some Thai Weed Extracts on Antioxidants and Atherosclerosis- Related Enzymes

et al. 2020

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This study used several methods to investigate the performance of aqueous extracts from some Thai weeds on antioxidants and atherosclerosis-related enzyme inhibitors. The inhibitory effect of aqueous extracts was expressed as the percentage of inhibition at a concentration of 500 µg/ml. GS-MS analysis was used to identify isolated compounds in sample extracts. The antioxidant activities were investigated using DPPH, ABTS, nitric oxide radical scavenging and oxidation of LDL. The results showed that the aqueous extract from the leaves of Bidens pilosa had greater inhibitory effects than others (71.23, 57.89 and 50.09%, respectively, except ABTS); however, B. pilosa had weaker inhibition than the positive controls. Pancreatic lipase and 15-lipoxygenase (15-LO) had inhibitory effects regarding atherosclerosis-related enzyme activities. The research found that Euphorbia hirta had stronger inhibitory activity against PL and 15-LO than other extracts (30.47 and 84.66%, respectively). Moreover, E. hirta had similar activity to quercetin against 15-LO (89.25%). Finally, isolated compounds were referred by GC-MC, the result presented more than 30 phenolic compounds and quite different characters, which might widely encouraged in antioxidants and inhibition of enzymatic activities. The results indicated that B. pilosa and E. hirta were the sources of bioactive compounds as antioxidants and anti-atherosclerosis, respectively.

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Euphorbia-Derived Natural Products with Potential for Use in Health Maintenance

Cited by 88 publications

References 95 publications

A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species

A Review of the Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species

Chemodiversity and biological activity of essential oils from three species from the Euphorbia genus

Performance of Some Thai Weed Extracts on Antioxidants and Atherosclerosis- Related Enzymes

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