Euphorbia Royleana Latex Keratitis

Sofat, B K; Sood, Gitanjli; Chandel, R D; Mehrotra, Santosh

doi:10.1016/0002-9394(72)90825-2

Cited by 25 publications

(20 citation statements)

References 2 publications

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“…Neglected cases can progress to blindness, and the literature includes reports of corneal scarring, iris synechiae, and anterior staphyloma. [2][3][4] It seems that most or all of these cases involved secondary bacterial infection. Recently, the self-limiting nature of appropriately managed cases has been emphasized.…”

Section: Commentmentioning

confidence: 99%

“…Ocular inflammation varies from a mild conjunctivitis to severe keratouveitis, and there have been several case reports of permanent blindness resulting from accidental exposure to the sap. [2][3][4] If the cornea is involved, changes generally follow a typical sequence, with worsening edema and epithelial sloughing on the second day. 2,5 While the literature regarding ocular damage from Euphorbia sap is relatively sparse, it is becoming apparent that some species are more toxic than others.…”

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confidence: 99%

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The Spectrum of Ocular Inflammation Caused by Euphorbia Plant Sap

Eke

Al-Husainy²,

Raynor³

2000

Arch Ophthalmol

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To report the spectrum of clinical findings in patients with ocular inflammation caused by plant sap from Euphorbia species.Design: Clinical case series.Setting: Ophthalmology emergency referrals in the United Kingdom.Patients: We examined 7 patients, all of whom gave a history of recent ocular exposure to the sap of Euphorbia species.Interventions: All patients were treated with antibiotic drops or ointment (chloramphenicol). Cycloplegic and steroid drops were also used for some patients. Patients were observed until all signs and symptoms had resolved.Main Outcome Measures: Symptoms, visual acuity, and clinical signs of inflammation. All patients provided a specimen of the plant for formal identification.Results: Initial symptoms were generally burning or stinging pain with blurred vision. In most cases, visual acuity was reduced between 1 and 2 Snellen lines. In 1 patient with agerelatedmaculopathy,acuitydroppedfrom20/80tohandmotions before recovering. Clinical findings varied from a mild epithelial keratoconjunctivitis to a severe keratitis with stromaledema,epithelialsloughing,andanterioruveitis.Allsigns and symptoms had resolved by 1 to 2 weeks.Conclusions: These cases illustrate the range of severity of Euphorbia sap keratouveitis. The condition seems to be self-limiting when managed supportively. People who work with Euphorbia plant species should wear eye protection. Clinicians managing keratopathy caused by Euphorbia species should be aware of the danger of sight-threatening infection and uveitis, particularly during the first few days.

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Section: Commentmentioning

confidence: 99%

mentioning

confidence: 99%

The Spectrum of Ocular Inflammation Caused by Euphorbia Plant Sap

Eke

Al-Husainy²,

Raynor³

2000

Arch Ophthalmol

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“…Ocular toxicity caused by various species of Euphorbia ranges from mild conjunctivitis to severe kerato-uveitis and even permanent blindness in some cases [40]. Euphorbia species also have been reported to cause corneal scarring, photo dermatitis, and corneal ulceration [41].…”

Section: African Plants Affecting the Eyesmentioning

confidence: 99%

African Plants with Dermatological and Ocular Relevance

Twilley

Lall

2014

Toxicological Survey of African Medicinal Plants

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“…Ocular toxic reaction varies from mild conjunctivitis to keratouveitis to severe corneal vascularization in neglected cases. There are a few case reports of permanent blindness resulting from accidental inoculation of Euphorbia sap into the eye [3][4][5]. Ocular toxicity can be caused by three different species of Euphorbia, namely, E. trigona (African milk tree), E. neriifolia (Indian Spurge tree) and E. milii (Crown-ofthorns houseplant).…”

Section: Introductionmentioning

confidence: 97%

Boston keratoprosthesis restoring vision in an unusual case of end-stage limbal stem cell deficiency following exposure to Euphorbia latex

et al. 2012

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We report the functional outcome of a patient who had undergone Boston keratoprosthesis type I for extensive ocular surface damage caused by latex of Euphorbia. The milky sap or latex of the Euphorbia plant is highly toxic and an irritant to the skin and eye. Damage to the eye ranges from mild to severe corneal edema, epithelial defects, anterior uveitis, secondary elevated intraocular pressure and, rarely, limbal stem cell deficiency with corneal neovascularization. A restrospective review was conducted of this patient for more than 1 year. During this period he was given subconjunctival bevacizumab injection to regress the corneal vascularization without much benefit, before finally performing Boston keratoprosthesis type I. The patient was evaluated periodically for both anatomical and visual outcome. At the end of 1-year follow-up the keratoprosthesis is well retained with a best-corrected visual acuity of 20/40 in the affected eye.

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Euphorbia Royleana Latex Keratitis

Cited by 25 publications

References 2 publications

The Spectrum of Ocular Inflammation Caused by Euphorbia Plant Sap

The Spectrum of Ocular Inflammation Caused by Euphorbia Plant Sap

African Plants with Dermatological and Ocular Relevance

Boston keratoprosthesis restoring vision in an unusual case of end-stage limbal stem cell deficiency following exposure to Euphorbia latex

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