EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries

Kotseva, Kornelia; Wood, David; Backer, Guy De; Bacquer, Dirk De; Pyörälà, Kalevi; Keil, Ulrich

doi:10.1097/hjr.0b013e3283294b1d

Cited by 747 publications

(585 citation statements)

References 51 publications

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“…The proportion of antiplatelet drug users at 6 months found in the present study was similar to that found in the EuroAspire III survey in the Netherlands 6. However, the proportion of antiplatelet drug users at 1 year in the present study was higher than that found in the Netherlands Heart Foundation (NHF) study, which reported 58–65% antiplatelet drug use at 1 year after MI hospitalization 16.…”

Section: Discussionsupporting

confidence: 81%

Patterns of antiplatelet drug use after a first myocardial infarction during a 10‐year period

Yasmina

Boer

Deneer

et al. 2016

Brit J Clinical Pharma

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AimsThe aims of the present study were to assess antiplatelet drug use patterns after a first myocardial infarction (MI) and to evaluate the determinants of antiplatelet nonpersistence.MethodsThe present study was conducted in 4690 patients from the Utrecht Cardiovascular Pharmacogenetics cohort with a first MI between 1986 and 2010, who were followed for a maximum of 10 years. Medication use and event diagnosis were obtained from the Dutch PHARMO Record Linkage System. Antiplatelet drug users were classified as persistent users (gap between prescriptions ≤90 days), nonpersistent users (>90‐day gap and no refills), and restarters (a new prescription after a >90‐day gap). The association between potential determinants and antiplatelet nonpersistence was analysed using Cox regression.ResultsThe proportions of persistent users decreased from 84.0% at the 1‐year follow‐up to 32.8% at 10 years for any antiplatelet drug, and 77.3% to 27.5% for aspirin; and 39.0% to 6.4% for clopidogrel at 6 years. Most nonpersistent users restarted antiplatelet drugs later, leading to 89.3% overall antiplatelet drug users at 10 years after MI. Diabetes (hazard ratio [HR] 0.44; 0.32–0.60), hypertension (HR 0.77; 0.60–0.99), hypercholesterolaemia (HR 0.49; 0.39–0.62) and more recent MI diagnosis period (2003–2007: HR 0.69, 0.61–0.79; 2008–2010: HR 0.38, 0.19–0.77, compared to ≤ 2002 period) lowered the risk of antiplatelet nonpersistence, while vitamin K antagonist (VKA) comedication (HR 18.97; 16.91–21.28) increased this risk.ConclusionsA large proportion of patients with a first MI still used antiplatelet drugs after 10 years. The frequent discontinuations during this time frame are expected to reduce the effectiveness of antiplatelet drugs as secondary prevention of cardiovascular diseases. Diabetes, hypertension, hypercholesterolaemia, VKA comedication and MI diagnosis period were determinants of antiplatelet nonpersistence.

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Section: Discussionsupporting

confidence: 81%

Patterns of antiplatelet drug use after a first myocardial infarction during a 10‐year period

Yasmina

Boer

Deneer

et al. 2016

Brit J Clinical Pharma

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“…Uma diretriz pode requerer, em média, um período de cinco anos para ser amplamente divulgada e suas recomendações passarem a ser transpostas para a prática clínica segundo mostrou o European Action on Secondary and Primary Prevencion by Intervention to Reduce Events III (EUROASPIRE III) 21 . A primeira diretriz de Prevenção da Aterosclerose na Infância e Adolescência foi lançada em 2005 e está prestes a completar o seu período de divulgação, sem, no entanto, ser conhecida por muitos profissionais, pelo menos na cidade de São Paulo.…”

Section: Discussionunclassified

Desconhecimento da diretriz de prevenção da aterosclerose na infância e adolescência por pediatras em São Paulo

Grosso

Santos

Luz

2010

Rev. Assoc. Med. Bras.

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ResumoObjetivO. Relatar a extensão do conhecimento de pediatras de São Paulo sobre a diretriz. MétOdOs. Durante eventos de pediatria ou nos locais de trabalho, pediatras responderam um questionário contendo informações sobre o tempo de formação, local de trabalho, dedicação dentro da área de pediatria, atuação em área acadêmica e questões de múltipla escolha com informações retiradas da diretriz. As diferenças de expressão e associações foram consideradas significantes estatisticamente quando p<0,05. Todas as análises foram realizadas usando teste de Quiquadrado e teste de Quiquadrado de tendência linear por meio dos Softwares Primer of Biostatistics ou SPSS for Windows. ResultadOs. Dos 370 pediatras entrevistados, 65,7% afirmaram não ter tido conhecimento prévio da diretriz. O valor de corte para os acertos foi maior ou igual a 70% (maior ou igual a cinco questões corretas). Apenas 136 pediatras (36,7%) alcançaram tal valor e dentre esses não havia relação no conhecimento da diretriz quanto aos sexos (p=0,25). Dos 187 profissionais envolvidos em atividades acadêmicas, 45 (24%) acertaram o valor de corte e dos 183 não participantes de atividades acadêmicas, 23 (12,7%) acertaram maior ou igual a cinco questões (p<0,001). Pediatras do setor público apresentaram melhor conhecimento da prática preventiva da aterosclerose (46,1%; p=0,01). O desconhecimento da diretriz foi independente do tempo de formação. COnClusãO. A meta da diretriz de servir como referência para o estabelecimento de estratégias individuais e populacionais no controle dos fatores de risco para a aterosclerose desde a infância não foi alcançada na cidade de São Paulo. A divulgação mais adequada e cursos de educação médica continuada em que o conhecimento da diretriz se torne mais efetivo são sugeridos para corrigir tais achados.unitermos: Prevenção primária. Aterosclerose. Criança. Adolescente. Diretrizes para o planejamento em saúde. desCOnheCiMentO da diRetRiz de pRevençãO da ateROsCleROse na infânCia e adOlesCênCia pOR pediatRas eM sãO paulO

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“…The input parameters for G*Power 3.1 were the desired statistical power (0.8), moderate anticipated effect size (0.15), and standard deviations of the predictor (L den : ≈ 5-10 dB; noise annoyance: 2.27 -1.43) and outcome variables (SBP: 20.4 mmHg; DBP: 12.3 mmHg). The latter were elicited from Dzhambov and Dimitrova 25 and Kotseva et al 26 . Overall, 217 patients were included: 111 from SGUH, 57 from KUH, and 49 from SKH (participation rates > 95%).…”

Section: Sample Sizementioning

confidence: 99%

Community Noise Exposure and its Effect on Blood Pressure and Renal Function in Patients with Hypertension and Cardiovascular Disease

Dzhambov¹,

Tokmakova²,

Gatseva³

et al. 2017

Folia Medica

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Citation: Dzhambov AM, Tokmakova MP, Gatseva PD, Zdravkov NG, Gencheva DG, Ivanova NG, Karastanev KI, Vladeva SV, Donchev AT, Dermendzhiev SM. Community noise exposure and its eff ect on blood pressure and renal function in patients with hypertension and cardiovascular disease.Folia Medica 2017;59(3): 344-356. doi: 10.1515/folmed-2017-0045 Background: Road traffi c noise (RTN) is a risk factor for cardiovascular disease (CVD) and hypertension; however, few studies have looked into its association with blood pressure (BP) and renal function in patients with prior CVD. Aim: This study aimed to explore the eff ect of residential RTN exposure on BP and renal function in patients with CVD from Plovdiv Province. Materials and methods:We included 217 patients with ischemic heart disease and/or hypertension from three tertiary hospitals in the city of Plovdiv (March -May 2016). Patients' medical history, medical documentation, and medication regimen were reviewed, and blood pressure and anthropometric measurements were taken. Blood samples were analyzed for creatinine, total cholesterol, and blood glucose. Participants also fi lled a questionnaire. Glomerular fi ltration rate was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. All participants were asked about their annoyance by diff erent noise sources at home, and those living in the city of Plovdiv (n = 132) were assigned noise map L den and L night exposure. The eff ects of noise exposure on systolic blood pressure (SBP), diastolic blood pressure (DBP), and estimated glomerular fi ltration rate (eGFR) were explored using mixed linear models. Results: Traffi c noise annoyance was associated with higher SBP in the total sample. The other noise indicators were associated with non-signifi cant elevation in SBP and reduction in eGFR. The eff ect of L den was more pronounced in patients with prior ischemic heart disease/stroke, diabetes, obesity, not taking Ca-channel blockers, and using solid fuel/gas at home. L night had stronger eff ect among those not taking statins, sleeping in a bedroom with noisy façade, having a living room with quiet façade, and spending more time at home. The increase in L den was associated with a signifi cant decrease in eGFR among men, patients with ischemic heart disease/stroke, and those exposed to lower air pollution. Regarding L night , there was signifi cant eff ect modifi cation by gender, diabetes, obesity, and time spent at home. In some subgroups, the eff ect of RTN was statistically signifi cant. Conclusions: Given that generic risk factors for poor progression of cardiovascular diseases cannot be controlled suffi ciently at individual level, environmental interventions to reduce residential noise exposure might result in some improvement in the management of blood pressure and kidney function in patients with CVD.

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EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries

Cited by 747 publications

References 51 publications

Patterns of antiplatelet drug use after a first myocardial infarction during a 10‐year period

Patterns of antiplatelet drug use after a first myocardial infarction during a 10‐year period

Desconhecimento da diretriz de prevenção da aterosclerose na infância e adolescência por pediatras em São Paulo

Community Noise Exposure and its Effect on Blood Pressure and Renal Function in Patients with Hypertension and Cardiovascular Disease

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