European Association of Urology Guidelines on Primary Urethral Carcinoma—2020 Update

Gakis, Georgios; Bruins, H.M.; Cathomas, Richard; Compérat, Eva; Cowan, Nigel C.; Heijden, Antoine G. van der; Hernández, Virginia; Espinós, Estefania E. Linares; Lorch, Anja; Neuzillet, Y.; Ribal, María J.; Rouanne, Mathieu; Thalmann, George N.; Veskimäe, Erik; Witjes, Alfred

doi:10.1016/j.euo.2020.06.003

Cited by 45 publications

(45 citation statements)

References 77 publications

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“…Various studies demonstrated that magnetic resonance imaging (MRI) and computed tomography (CT) using iodinated contrast media could be valuable for evaluating extravesical extension, tumoral infiltration and lymph node metastasis in bladder cancer [13]. However, CT and MRI scan are expensive and sometimes unsafe because of adverse reactions associated with using iodine as a contrast medium.…”

Section: Discussionmentioning

confidence: 99%

Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Kang

et al. 2020

BMC Med Imaging

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Background: Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is an uncommon malignant bladder tumor, and the overall prognosis is poor. Contrast-enhanced ultrasound (CEUS) provides a new effective modality for tumor detection and diagnosis. Case presentation: A 30-year-old man complained of repeated painless gross haematuria for half a month. Conventional ultrasound demonstrated a hypoechoic solitary lesion with hyperechoic margins measuring 3.4 × 3.1 cm in the anterior wall of the bladder. Superb microvascular imaging (SMI) showed a strong flow signal in the mass. CEUS revealed that the lesion was characterized by hyper-enhancement in the early phase and hypoenhancement in the late phase. The entire bladder wall was disrupted by homogeneous hyper-enhanced tumor tissue on CEUS. Time-intensity curves (TICs) showed a rapid wash-in with a high maximum signal intensity (SI) and quick wash-out. Finally, partial cystectomy was performed and the pathological examination confirmed the diagnosis of LCNEC with invasion into the whole layer of the bladder wall. Conclusion: This case suggested that CEUS was a valuable imaging method to detect and diagnose LCNEC in the bladder, and that CEUS can provide information related to the depth of wall invasion and the microvasculature.

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Section: Discussionmentioning

confidence: 99%

Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Kang

et al. 2020

BMC Med Imaging

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“…El cáncer de uretra representa menos del 1% de las neoplasias genitourinarias en mujeres, entre sus tipos histológicos se encuentra el carcinoma urotelial de uretra, el cual es el tipo más frecuente de cáncer primario comprendiendo un 54-65% de los casos, seguido del carcinoma de células escamosas Presentación de reporte de caso: adenocarcinoma de célula clara de uretra González y col 16-22% y por último el adenocarcinoma de célula clara con una incidencia del 10-16%, este último es un tumor agresivo y poco frecuente en la población general, es más común en mujeres posmenopáusicas con un rango de edad entre los 35-80 años, con un promedio de presentación a los 58 años. 3,4 Esta enfermedad se ha relacionado con la alteración anatómica uretral como la presencia de divertículo uretral, el cual ha sido documentado en 1/3 de los casos reportados, sin embargo, la histogénesis no se ha dilucidado completamente. 5 Se ha propuesto que puede ser derivado del urotelio metaplásico, restos de Müller, glándulas periuretrales de Skene o de transformación maligna de un adenoma nefrogénico.…”

Section: Discussionunclassified

“…En la cistoscopia se puede visualizar la presencia de tumor y si se realiza biopsia se puede confirmar el diagnóstico histológico. 3 Microscópicamente el tumor exhibe un patrón túbuloquístico, papilar o difuso, las células tumorales son cuboidales con abundante citoplasma claro y presencia de vacuolas y glóbulos hialinos, necrosis, pleomorfismo nuclear y frecuentes mitosis. La inmunohistoquímica suele ser positiva para PAX2, PAX8, citoqueratina 7, p16, p53, CA125, molecularmente también expresan alfa metilacil-CoA racemasa, HNF1B y CK34BE12, p53, Ki-67.…”

Section: Discussionunclassified

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Presentación de reporte de caso: adenocarcinoma de célula clara de uretra

et al. 2018

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“…BC is the fourth leading cancer in men and the eighth in women (34). This disease leads to poor patient prognosis in patients treated by radical cystectomy, radiation therapy and postoperative instillation of chemotherapy or immunotherapy (35,36). Zhong et al (37) demonstrated that SNHG7 expression was elevated in BC cell lines.…”

Section: Snhg7 In Bladder Cancer (Bc)mentioning

confidence: 99%

The role of long noncoding RNA SNHG7 in human cancers (Review)

Zheng

et al. 2020

Mol Clin Oncol

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Long non-coding RNAs (lncRNAs) have been demonstrated to serve important roles in a variety of human tumor types. The lncRNA small nucleolar RNA host gene 7 (SNHG7) is associated with a variety of cancer types, such as esophageal cancer, breast cancer and gastric neoplasia. Based on previous studies that examined SNHG7 expression in tumors, it has become clear that SNHG7 modulates tumorigenesis and cancer progression by acting as a competing endogenous RNA. SNHG7 can sponge tumor-suppressive microRNAs and regulate downstream signaling pathways. In addition, overexpression of SNHG7 is associated with the clinical characteristics of patients with cancer by regulating cellular proliferation, invasion and metastasis and by inhibiting apoptosis via a variety of mechanisms of action. The function of SNHG7 in tumorigenesis and cancer progression indicates that it can potentially act as a novel therapeutic target or a diagnostic biomarker for cancer therapy or detection, respectively. Contents 1. Introduction 2. Characterization of SNHG7 3. SNHG7 dysregulation in human cancers 4. Conclusion and future perspectives

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European Association of Urology Guidelines on Primary Urethral Carcinoma—2020 Update

Cited by 45 publications

References 77 publications

Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Application of contrast-enhanced ultrasonography for large cell neuroendocrine carcinoma in the urinary bladder: a case report

Presentación de reporte de caso: adenocarcinoma de célula clara de uretra

The role of long noncoding RNA SNHG7 in human cancers (Review)

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