In this study, the medium‐range predictability of heatwave (HW) onsets in four midlatitude European regions is investigated statistically with the help of ensemble reforecasts for the period 2001–2018. The concept of Euro‐Atlantic weather regimes is adopted to characterise HWs (about 50 in each region) and to study whether forecast skill may depend on the large‐scale dynamical setup. HW onsets over the British Isles and Scandinavia are mainly associated with Scandinavian and European blocking regimes, whereas the “no regime” case is observed more frequently for Central Europe. Stratified by weather regime, the predictability of heatwave onsets is then studied by means of a multiple metric‐based analysis of European Centre for Medium‐Range Weather Forecasts (ECMWF) and Global Ensemble Forecast System Version 12 (GEFSv12) ensemble reforecasts. For two of the regions considered, Central Europe and the British Isles, a conclusive picture is obtained: medium‐range predictive skill is significantly higher for HW onsets associated with Scandinavian or European blocking compared with cases with no pronounced regime. This skill advantage mostly concerns the large‐scale flow and, to some extent, 850‐hPa temperatures, but is generally not reflected in the correct prediction of near‐surface temperatures. Finally, we investigate for two regions how exceptionally good or poor forecasts are related to the atmospheric state during or shortly after forecast initialisation. At 10 days lead time, poor large‐scale flow predictive skill for Central European HW onsets is linked to anomalously high baroclinicity further upstream and an intensified North Atlantic jet stream, whereas good forecasts on average feature an initial state close to climatology. Forecast skill for near‐surface temperatures is not affected by such dynamical precursors, but rather by pre‐existing soil‐moisture anomalies. For the British region, exceptionally good forecasts of both large‐scale flow and near‐surface temperatures are associated with an already established continental blocking. In contrast to Central Europe, pre‐existing soil‐moisture anomalies play less of a role there.