European trends in radiology: investigating factors affecting the number of examinations and the effective dose

Masjedi, Hamidreza; Zare, Mohammad Hosein; Siahpoush, Neda Keshavarz; Razavi-Ratki, Seid Kazem; Alavi, Fatemeh; Shabani, Masoud

doi:10.1007/s11547-019-01109-6

Cited by 36 publications

(23 citation statements)

References 49 publications

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“…On account of progress of the estimation of the stochastic effects risk, the ICRP has changed the calculation of ED several times (35). The most recent change was in 2007 and it was remarkable, for the reason that weights of several tissues were changed (35,36). The effective dose is defined by ICRP as "the weighted sum of the mean doses to a number of radiosensitive tissues or organs in the body" (35,37).…”

Section: Effective Dosementioning

confidence: 99%

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Measures of patient exposure to ionizing radiation during interventional radiology procedures

Opančina¹,

Vojinović²

2019

Medicinski časopis

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Section: Effective Dosementioning

confidence: 99%

“…It is necessary to keep in mind that ED cannot be utilized to assess individual risk of patients' radiation exposure, due to the use of average characteristics, such as age and gender (1,36). Still, ED is used to present the relative risk (35,38).…”

Section: Effective Dosementioning

confidence: 99%

Measures of patient exposure to ionizing radiation during interventional radiology procedures

Opančina¹,

Vojinović²

2019

Medicinski časopis

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“…The rise in the number of medical examinations using ionising radiation, such as CT scans, has led to an increased collective dose for patients at the European level, with a potentially heightened risk for patients undergoing repeated procedures, especially for young patients (Bernier et al, 2018;Masjedi et al, 2019). There is a need to evaluate the health effects of these exposures, optimise practices to reduce doses, and develop dose evaluation tools that can be used in clinical practice to ensure adequate and improved radiation protection for patients and medical professionals.…”

Section: Introductionmentioning

confidence: 99%

MEDIRAD formulation of science-based recommendations for medical radiation protection: a stakeholder forum survey

et al. 2021

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MEDIRAD (Implications of Medical Low Dose Radiation Exposure) is an innovative European research project funded by EURATOM which seeks to bring closer together the nuclear and medical research communities in order to advance science for radiation protection in radiotherapy, nuclear medicine, and diagnostic and interventional radiology. The project also aims to promote links between science and society, with the goal of better protecting patients and professionals, through the publication of recommendations based on MEDIRAD research findings (http://www.medirad-project.eu/). The MEDIRAD Stakeholder Forum (SF) was designed to set up a dialogue between the Consortium member organisations and the society regarding the recommendations, which are expected from this project. We envisage three successive steps in this dialogue (1: first SF consultation identifying the needs for improved medical radiological protection; 2: drafting science based MEDIRAD recommendation and 3: second SF consultation to collect feedback), which are implemented throughout the project. A first overview of input of the Stakeholder Forum about the topics to be addressed in the MEDIRAD recommendations, based on an exploratory questionnaire, is presented in this article. Quantitative and qualitative in-depth analysis leads to the identification of 11 priority thematics.

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“…Exposure to genotoxic stress, such as ionizing radiation, chemical agents or viral infections is an inevitable by-product of modern life ( McLean and Adlen, 2017 ; Masjedi et al, 2020 ). X-rays are widely used in industry, as well as in healthcare ( Power et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Is Response to Genotoxic Stress Similar in Populations of African and European Ancestry? A Study of Dose-Response After in vitro Irradiation

Soumboundou¹,

Dossou²,

Kalaga³

et al. 2021

Front. Genet.

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Background: Exposure to genotoxic stress such as radiation is an important public health issue affecting a large population. The necessity of analyzing cytogenetic effects of such exposure is related to the need to estimate the associated risk. Cytogenetic biological dosimetry is based on the relationship between the absorbed dose and the frequency of scored chromosomal aberrations. The influence of confounding factors on radiation response is a topical issue. The role of ethnicity is unclear. Here, we compared the dose-response curves obtained after irradiation of circulating lymphocytes from healthy donors of African and European ancestry.Materials and Methods: Blood samples from six Africans living in Africa, five Africans living in Europe, and five Caucasians living in Europe were exposed to various doses (0–4 Gy) of X-rays at a dose-rate of 0.1 Gy/min using an X-RAD320 irradiator. A validated cohort composed of 14 healthy Africans living in three African countries was included and blood samples were irradiated using the same protocols. Blood lymphocytes were cultured for 48 h and chromosomal aberrations scored during the first mitosis by telomere and centromere staining. The distribution of dicentric chromosomes was determined and the Kruskal-Wallis test was used to compare the dose-response curves of the two populations.Results: No spontaneous dicentric chromosomes were detected in African donors, thus establishing a very low background of unstable chromosomal aberrations relative to the European population. There was a significant difference in the dose response curves between native African and European donors. At 4 Gy, African donors showed a significantly lower frequency of dicentric chromosomes (p = 8.65 10–17), centric rings (p = 4.0310–14), and resulting double-strand-breaks (DSB) (p = 1.32 10–18) than European donors. In addition, a significant difference was found between African donors living in Europe and Africans living in Africa.Conclusion: This is the first study to demonstrate the important role of ethnic and environmental factors that may epigenetically influence the response to irradiation. It will be necessary to establish country-of-origen-specific dose response curves to practice precise and adequate biological dosimetry. This work opens new perspective for the comparison of treatments based on genotoxic agents, such as irradiation.

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European trends in radiology: investigating factors affecting the number of examinations and the effective dose

Cited by 36 publications

References 49 publications

Measures of patient exposure to ionizing radiation during interventional radiology procedures

Measures of patient exposure to ionizing radiation during interventional radiology procedures

MEDIRAD formulation of science-based recommendations for medical radiation protection: a stakeholder forum survey

Is Response to Genotoxic Stress Similar in Populations of African and European Ancestry? A Study of Dose-Response After in vitro Irradiation

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