EUS-guided Nd:YAG laser ablation of normal pancreatic tissue: a pilot study in a pig model

Matteo, Francesco Di; Martino, Margareth; Rea, R. Lindsay; Pandolfi, M.; Rabitti, Carla; Masselli, Grazia Maria Paola; Silvestri, Sergio; Pacella, Claudio Maurizio; Papini, Enrico; Panzera, Francesco; Valeri, Sergio; Coppola, Roberto; Costamagna, Guido

doi:10.1016/j.gie.2010.02.027

Cited by 78 publications

(43 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data confirm the few ones already available in the international literature 12,13 as we agree that the best power setting is between 4 W and 6 W. Moreover, we were able to find out why in the previous studies, 12 the authors found no hemorrhage: the laser waves, in fact, allow a complete coagulation of the vessels in the area of application. The main limitations of the present study are that this is an ex vivo study and not on human tissue.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Dioscoridi¹,

Sordi²,

Breschi³

et al. 2016

Pancreas Open J

View full text Add to dashboard Cite

Research ABSTRACTBackground: Pancreatic surgery is one of the most difficult and life-threatening surgical therapy especially during necrotizing pancreatitis and advanced solid neoplasms. Aim of the study: To evaluate the possibility to use ECHO Neodymium-Doped Yttrium Aluminium Garnet (ND-YAG) laser in pancreatic surgery and to establish the best power setting for the application on pancreatic tissue. Methods: An ECHO Laser ND-YAG 1064 nm, at the constant fluence of 1800 J/cm 2 was used. The laser waves were inserted inside of the samples with optical fibers of 500 micron diameter for a pre-established timing (11 min, 6 min, 4 min) in order to reach the constant fluence. Samples were, then, prepared for hystological examination. Results: At 3W power setting, the pancreatic tissue was not macroscopically modified except for an increased cutting consistency. Histological examination showed no substantial microscopical differences in pancreatic cells that appeared only partially burnt (in fact, nuclei and membranes are still recognizable). The vessels in the surrounding area have the normal morphological aspects. At 5W, macroscopically the presence of a completely burnt area, corresponding to the site of direct interaction of laser and tissue, was found and the surrounding tissue did not appear substantially modified. Histological examination showed the complete absence of cells in the burnt area and an important heat damage of the surrounding cells till the 2 th centimeter from the site of laser application. The vessels in the heat damage area appeared completely coagulated. At the power of 7 W, the burnt area was about twice than in the previous setting and histological examination showed the complete absence of cells in the burnt area and a larger heat damage of the nearest cells (till the 4 th centimeter from the application site). The vessels in heat damage area were found completely coagulated. Conclusions: A power setting between 4 and 6 W have been found as the best one for laser application on pancreatic tissue because a complete destruction of the cells in the site of application but a limited heat damage in the surrounding healthy cells have been obtained.

show abstract

Section: Discussionsupporting

confidence: 90%

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Dioscoridi¹,

Sordi²,

Breschi³

et al. 2016

Pancreas Open J

View full text Add to dashboard Cite

show abstract

“…No pancreatitis was noted in the successful group, although an increase in amylases was seen in 3 of the 16 patients [128,129]. However, the impact on survival or tumor size needs further evaluation.…”

Section: Eus-guided Tumor Ablationmentioning

confidence: 90%

“…Ablation with a neodymium:yttrium-aluminum-garnet laser was tried in a porcine model, following the results in hepatocellular carcinoma, and no major complications were noted [129].…”

Section: Eus-guided Tumor Ablationmentioning

confidence: 99%

Endoscopic Ultrasound in Pancreatic Cancer: The New Perspective

Seicean¹

2014

Pancreatic Cancer - Insights Into Molecular Mechanisms and Novel Approaches to Early Detection and Treatment

View full text Add to dashboard Cite

“…Under EUS guidance with a 19-gauge fine needle, a neodymium: Yttrium aluminum garnet (Nd:YAG) laser at 1.064 nm with an output power of 2 and 3 W and a total delivered energy of 500 and 1000 J was inserted into the pancreatic tail 43. Tissue necrosis was observed in all animals on histological examination.…”

Section: Rfamentioning

confidence: 99%

Role of endoscopic ultrasound in treatment of pancreatic cancer

Guo¹,

Cui²,

Hu³

2013

Endosc Ultrasound

View full text Add to dashboard Cite

Endoscopic ultrasound (EUS) can help diagnose diseases with high accuracy because it overcomes the limitations of gastrointestinal gas and abdominal fat. The emergence of curved linear-array echoendoscopy has significantly promoted the applications of the technique to new levels. The advancement has appeared from EUS imaging to EUS-guided fine needle aspiration, drainage and injection. Computed tomography and magnetic resonance imaging present certain limitations for diagnosing pancreatic tumors due to the specificity of the location of such growths. In addition, traditional chemotherapy does not show ideal results because pancreatic cancer (PC) exhibits hypovascular characteristics. Interventional EUS can overcome these limitations and has potential to become the mainstream method of PC local treatment in the future. This paper reviews the use of interventional EUS in the treatment of PC based on previous studies.

show abstract

EUS-guided Nd:YAG laser ablation of normal pancreatic tissue: a pilot study in a pig model

Cited by 78 publications

References 21 publications

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Evaluation of the Best Power Setting of Laser Waves in Pancreatic Surgery: ECHO ND-YAG Laser Ablation on Bovine Pancreatic Tissue

Endoscopic Ultrasound in Pancreatic Cancer: The New Perspective

Role of endoscopic ultrasound in treatment of pancreatic cancer

Contact Info

Product

Resources

About