Evaluación de las concentraciones séricas de procalcitonina como indicador de gravedad y mortalidad en sepsis abdominal por peritonitis secundaria

Godínez-Vidal, Ansony R; Verónica, Rojas-Hernández; Montero-García, Paola J; Martínez-Martínez, Antonio R; Zavala-Castillo, Julio C.; Gracida-Mancilla, Noé I

doi:10.24875/ciru.18000301

Cited by 3 publications

(1 citation statement)

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“… 32 Elevated PCT was associated with abdominal sepsis (most commonly appendicitis) (Mexico). 33 Patients with abdominal sepsis had higher CRP than those with pulmonary sepsis (mean 178 versus 149 mg/L) (Brazil). 34 …”

Section: Resultsmentioning

confidence: 99%

C-reactive protein and procalcitonin use in adults in low- and middle-income countries: a narrative review

Lamrous

Repetto

Depp

et al. 2023

JAC-Antimicrobial Resistance

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Objectives C-reactive protein (CRP) and procalcitonin (PCT) are widely used biomarkers in high-income countries. However, evidence for their use in low- and middle-income countries (LMICs) is scant. Because many factors, including rates of endemic disease, comorbidities and genetics, may influence biomarkers’ behaviour, we aimed to review available evidence generated in LMICs. Methods We searched the PubMed database for relevant studies within the last 20 years that originated in regions of interest (Africa, Latin America, Middle East, South Asia or South East Asia), and full-text articles involving diagnosis, prognostication and evaluation of therapeutic response with CRP and/or PCT in adults (n = 88) were reviewed and categorized in 12 predefined focus areas. Results Overall, results were highly heterogeneous, at times conflicting, and often lacking clinically useful cut-off values. However, most studies demonstrated higher levels of CRP/PCT in patients with bacterial versus other infections. HIV and TB patients had consistently higher levels of CRP/PCT versus controls. In addition, higher CRP/PCT levels at baseline and follow-up in HIV, TB, sepsis and respiratory tract infections were associated with poorer prognosis. Conclusions Evidence generated from LMIC cohorts suggests that CRP and PCT may have potential to become effective clinical guiding tools particularly in respiratory tract infections, sepsis and HIV/TB. However, more studies are needed to define potential scenarios for use and cost-effectiveness. Consensus across stakeholders regarding target conditions, laboratory standards and cut-off values would support the quality and applicability of future evidence.

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Section: Resultsmentioning

confidence: 99%

C-reactive protein and procalcitonin use in adults in low- and middle-income countries: a narrative review

Lamrous

Repetto

Depp

et al. 2023

JAC-Antimicrobial Resistance

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Inflammation and Sepsis Biomarkers in Diagnosis of the Generalized Peritonitis Stage

Saraev¹,

Назаров²,

Ali-Zade³

et al. 2020

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The values of indices of non-specific resistance and cytokine regulation for early diagnosis of secondary peritonitis

Droniak,

Shevchuk,

Snizhko

et al. 2023

Med. perspekt.

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The aim of the work is to study the changes in indices of non-specific resistance and cytokine regulation, relevant for the early diagnosis of secondary peritonitis. During the period 2016-2022, in the Surgery Department of the Communal Non-Profit Enterprise “Regional Clinical Hospital, Ivano-Frankivsk Regional Council” there were treated 192 patients with postoperative peritonitis. Of them, in 69 (35.9%) patients the changes in indices of non-specific resistance and cytokine regulation were studied. These studies were performed in the laboratory of the Department of Biological and Medical Chemistry of the Ivano-Frankivsk National Medical University. The content of CD3+-lymphocytes in the blood of patients with secondary peritonitis on admission to the hospital was 35.49±3.39%, which is 1.8-fold less than in the comparison group (p<0.002), with their subsequent drop up to 31.00±2.88% (p<0.002) during the third day of the disease. When determining CD4+-lymphocytes during the first day of observation, their indices were 21.49±3.11%, by 56% less than in the comparison group (p<0.002). During the third day of the disease, we observed a slight increase in this index – up to 23.90±3.26% (p<0.01). The study of the level of CD8+-lymphocytes showed that, on admission to the hospital, their level in blood serum was 13.92±1.05%, which is 1.6-fold lower than in patients of the comparison group (p<0.002). Their decrease was observed further, and during the third day this index was 8.08±2.28% (p<0.002). The content of CD11a+-cells on hospitalization was 11.32±0.54%, which is more than 6-fold less than in the comparison group (p<0.002). The content of CD162+-cells in the blood on hospitalization was 21.49±3.11%, which is 3.1-fold less than in the comparison group (p<0.002). The content of CD16+-cells in the blood on hospitalization was 10.83±0.87% (p<0.002). A significant increase in the content of IL in the blood serum at the initial stage of secondary peritonitis with subsequent pathological changes are contributing factors in the disorder of the body’s immune response. The content of IL-6 on admission was 759.72±28.06%, which is almost 3.4-fold higher than the indices in the comparison group (p<0.002). After surgery, this index gradually decreased and during the seventh day was 438.63±19.84% (p<0.002). The results obtained on such indices of non-specific resistance and cytokine regulation as CD3+, CD4+, CD8+, CD11a, CD162, CD95, CD16, HLA-DR+, IL-2, IL-4, IL-6 showed their significant differences between the subgroups studied (p<0.002), indicating their high sensitivity for diagnosing and predicting the development of secondary peritonitis.

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Evaluación de las concentraciones séricas de procalcitonina como indicador de gravedad y mortalidad en sepsis abdominal por peritonitis secundaria

Cited by 3 publications

References 0 publications

C-reactive protein and procalcitonin use in adults in low- and middle-income countries: a narrative review

C-reactive protein and procalcitonin use in adults in low- and middle-income countries: a narrative review

Inflammation and Sepsis Biomarkers in Diagnosis of the Generalized Peritonitis Stage

The values of indices of non-specific resistance and cytokine regulation for early diagnosis of secondary peritonitis

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