Evaluasi Penggunaan Antibiotika Pada Pasien Leukemia Limfoblastik Akut Dengan Demam Neutropenia Di Rumah Sakit Umum Daerah Abdul Wahab Sjahranie Samarinda

Abstract

ABSTRACT
 
 The use of antibiotics is one of the management of neutropenic fever in patients with acute
 lymphoblastic leukemia (ALL). Irrational and excessive antibiotics can promote resistance to
 certain bacteria. The aim of this study was to evaluate the use of antibiotics given to ALL patients
 with neutropenic fever qualitatively and quantitatively. This type of observational research was
 conducted with a descriptive method using a cross-sectional design. Retrospective data collection
 from medical records of ALL patients who received antibiotics during 2017-2018. The quality of
 antibiotic use was analyzed using the Gyssens method, while the quantity of antibiotic use was
 analyzed using the DDD method per 100 bed days. Based on the results of the study of 7 ALL
 patients with neutropenic fever, the rational (category 0) use of antibiotics was 50% and the
 irrational (category I-IV) use of antibiotics was 50%. The use of inappropriate antibiotic dose (category IIA) was 25%, the use of the antibiotic inaccurate interval of use (category IIB) was
 10%, and there was no indication that antibiotic use (category V) was 15%. Quantitative
 evaluation of the use of antibiotics using the DDD method per 100 bed days showed that the total
 use of antibiotics was 7 types with a DDD value of 100 patient days of 19.15. The most widely used
 antibiotic is the cephalosporin class, namely cefotaxime with a DDD value of 6.51.
 
 Keywords: antibiotics, leukemia, quality, quantity