Evaluating exercise capacity in patients with pulmonary arterial hypertension

Babu, Abraham Samuel; Myers, Jonathan; Arena, Ross; Maiya, Arun G.; Padmakumar, R

doi:10.1586/erc.13.33

Cited by 18 publications

(15 citation statements)

References 60 publications

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“…Standardization of the pediatric CPET has been difficult, [132][133][134] and studies have suggested that CPET in adults does not correlate with quality of life or mortality risk, preventing its widespread adoption as a clinical end point in clinical trials. 135 Pediatric CPET using the bicycle ergometer is usually possible in children >7 years of age, and younger children may be able to perform CPET on a treadmill. Heart rate and rhythm, oxygen saturation, and blood pressure are recorded in all subjects, and values at which the test will be halted are set a priori by clinical personnel.…”

Section: Cardiopulmonary Exercise Testingmentioning

confidence: 99%

Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

949

405

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Abstract-Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patients with pulmonary hypertension have been limited by the lack of consensus guidelines from experts in the field. In a joint effort from the American Heart Association and American Thoracic Society, a panel of experienced clinicians and clinician-scientists was assembled to review the current literature and to make recommendations on the diagnosis, evaluation, and treatment of pediatric pulmonary hypertension. This publication presents the results of extensive literature reviews, discussions, and formal scoring of recommendations for the care of children with pulmonary hypertension. Key Words: AHA Scientific Statements ◼ bronchopulmonary dysplasia ◼ congenital diaphragmatic hernia ◼ congenital heart disease ◼ genetics ◼ persistent pulmonary hypertension of the newborn ◼ sickle cell disease © 2015 by the American Heart Association, Inc., and the American Thoracic Society.Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0000000000000329 †Deceased. The American Heart Association and the American Thoracic Society make every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This document was approved by the American Heart Association Science Advisory and Coordinating Committee on May 12, 2015, the American Heart Association Executive Committee on July 22, 2015, and the American Thoracic Society on July 24, 2015.The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIR.0000000000000329/-/DC1. The American Heart Association requests that this document be cited as follows: Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; on behalf of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Surgery and Anesthesia, and the American Thoracic Society. Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society. Circulation. 2015;132:2037-2099 Copies: This document is available on the World Wide Web site of the American Heart Associat...

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Section: Cardiopulmonary Exercise Testingmentioning

confidence: 99%

Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

949

405

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“…Pulmonary hypertension (PH) is a condition causing severe functional limitations and poor quality of life [1]. Fatigue and dyspnoea are the result of dysfunction in the various physiological systems of the body which result in poor function.…”

Section: Introductionmentioning

confidence: 99%

Effects of the Pulmonary Hypertension Manual (PulHMan) on Awareness of Exercise in Patients with Pulmonary Hypertension

Babu

Ramachandran

Maiya

2016

Heart, Lung and Circulation

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“…The prognostic role of CPX variables in assessing survival in PAH has also been demonstrated with a building evidence base. [48,62] ; P = 0.003). [67] This suggests that in addition to measurement of the distance covered during the 6MWT, desaturation and heart rate recovery (a surrogate marker of autonomic function) may need to be measured and documented.…”

Section: Prognostic Rolementioning

confidence: 95%

Exercise-based evaluations and interventions for pulmonary hypertension with connective tissue disorders

Babu

Morris

Arena

et al. 2018

Expert Review of Respiratory Medicine

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Exercise intolerance is a common and often significant limitation in pulmonary arterial hypertension (PAH). This intolerance greatly affects the quality of life and function of the individual with PAH, irrespective of its etiology. In PAH associated with connective tissue disorders (PAH-CTD), exercise intolerance is further amplified by the presence of coexisting musculoskeletal manifestations of CTD. The evaluation of exercise capacity and prescription for exercise training therefore becomes a challenge to the clinician. Areas covered: This review highlights factors contributing to exercise intolerance in PAH-CTD, evaluation methods of exercise capacity and an overview on exercise training and a roadmap for future research. Expert commentary: Exercise intolerance is a complex interplay of cardiovascular, pulmonary, and musculoskeletal systems. Data from cardiopulmonary exercise tests have shown predictive abilities for both diagnosis and prognosis. In its absence, the 6-min walk test can be used to provide similar information thereby making the role of exercise testing an invaluable evaluation method in PAH-CTD. Exercise training data in PAH-CTD are still sparse, though, data from PAH studies suggest potential benefit. However, more research is required in this area of testing and training for greater understanding on exercise hemodynamic, phenotypes, and training benefits.

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Evaluating exercise capacity in patients with pulmonary arterial hypertension

Cited by 18 publications

References 60 publications

Pediatric Pulmonary Hypertension

Pediatric Pulmonary Hypertension

Effects of the Pulmonary Hypertension Manual (PulHMan) on Awareness of Exercise in Patients with Pulmonary Hypertension

Exercise-based evaluations and interventions for pulmonary hypertension with connective tissue disorders

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