Cikakembang River, a tributary of Citarum River, is situated in the densely populated Majalaya District, renowned for textile production. Direct discharges of domestic and industrial pollutants into the river contribute to substantial pollution, making it crucial to manage pollution levels. This implies that controlling pollution is crucial, as it significantly impacts the condition of Citarum River, already infamous as one of the world most polluted rivers. A key indicator for assessing river water quality is Biological Oxygen Demand (BOD), representing the oxygen required for microorganism-mediated decomposition. This parameter is influenced by deoxygenation rate, denoted as kd. Therefore, this study aimed to analyze the most suitable kd value for Cikakembang River using various empirical methods, including Simple, Fujimoto, Sawyer, Thomas, Fair, and Hydroscience. The result showed that Thomas method provided the most accurate prediction for BOD concentration of the river. In rainy season, Root mean square error (RMSE), mean absolute percentage error (MAPE), and coefficient of determination (R2) values were 0.542, 0.035, and 0.981, respectively, and in dry season, the values were 0.117, 0.009, and 0.999. Additionally, kd value effectively simulated the river water quality using HEC-RAS, yielding satisfactory results. RMSE, MAPE, and R2 values for BOD concentration were 3.551, 0.162, and 0.331 in rainy season and 1.071, 0.100, and 0.812 in dry season. Finally, the modeling result showed that Cikakembang River did not meet the Class 2 Water Quality Standard during both rainy and dry seasons. This finding is critical, as it underscores the severity of the pollution problem in the river and the urgent need for comprehensive and effective management strategies to improve its water quality.