Evaluating neem gum-polyvinyl alcohol (NGP-PVA) blend nanofiber mat as a novel platform for wound healing in murine model

Rajora, Aditya Dev; Bal, Trishna

doi:10.1016/j.ijbiomac.2022.12.014

Cited by 12 publications

(3 citation statements)

References 24 publications

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“…The temperatures corresponding to the maximum decomposition rate during two decomposition processes are labeled as T max1 and T max2 , respectively. The first mass loss (approximately 67%) is mainly attributed to the elimination reactions, which mainly produces water and conjugated and non-conjugated polyenes; the second mass loss (approximately 19%) reveals the chain scission of PVA chains and cyclization reactions, which forms low-molecular-weight polyenes and ketones. − Compared with pure PVA film, the onset decomposition temperature ( T 5 ) of HPS-filled syntactic foam films, at which syntactic foam films were degraded by 5 wt %, increases by 55.8–66.5 °C, while T max1 and T max2 values of these syntactic foam films are raised by 10.2–11.8 and 3.5–8.8 °C, respectively.…”

Section: Resultsmentioning

confidence: 99%

Teardrop-Shaped Hollow Polystyrene Nanoparticles for Improving the Mechanical and Thermal Properties of Polyvinyl Alcohol-Based Syntactic Foam Films

Chen,

Cao,

Wang

et al. 2023

ACS Appl. Nano Mater.

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The application of polyvinyl alcohol (PVA) films is still restricted due to their poor hydrophilicity, mechanical strength, and thermal stability. To improve these properties, a teardrop-shaped hollow polystyrene (HPS) nanoparticle was prepared in this work and further applied as the reinforcing nanomaterial. Herein, a teardrop-shaped silica nanoparticle was first used as the hard template; polystyrene was in situ-synthesized on the surface of teardrop-shaped silica, followed by the etching of the silica template. By tuning the synthesis parameters (e.g., styrene concentration and etching time), the optimal structure of HPS was obtained; subsequently, HPS was mixed with PVA by a solution-mixing method, which in turn produced the PVA-based synthetic foam film. Using optimal synthesis parameters of HPS and its loadings, the obtained syntactic foam films exhibited high transparency, excellent mechanical strength and toughness, and good thermal stability. Compared to pure PVA film, the tensile strength and toughness of PVA-based syntactic foam films containing 1.0 wt % HPS were improved by about 55 and 77%, respectively; the glass transition temperature and onset decomposition temperature of PVA-based syntactic foam films increased to about 32 and 66 °C, respectively. The research exemplifies the great promise of HPS toward practical application in polymer syntactic foams.

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Section: Resultsmentioning

confidence: 99%

Teardrop-Shaped Hollow Polystyrene Nanoparticles for Improving the Mechanical and Thermal Properties of Polyvinyl Alcohol-Based Syntactic Foam Films

Chen,

Cao,

Wang

et al. 2023

ACS Appl. Nano Mater.

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“…It is also worth noting the excellent antibacterial activity of the material against gram-positive and gram-negative bacteria, evidencing the promising use of these nanofibers in wound healing applications. Rajora and colleagues prepared a nanofiber mat of neem gum polysaccharide with PVA using an electrospinning technique (Rajora and Bal, 2022). This nanofiber showed hemocompatibility, as well as, biodegradability having antimicrobial activity against Escherichia coli and Staphylococcus aureus.…”

Section: Polyvinyl Alcoholmentioning

confidence: 99%

Polymeric biomaterials for wound healing

Oliveira¹,

Sousa²,

Teixeira³

et al. 2023

Front. Bioeng. Biotechnol.

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Skin indicates a person’s state of health and is so important that it influences a person’s emotional and psychological behavior. In this context, the effective treatment of wounds is a major concern, since several conventional wound healing materials have not been able to provide adequate healing, often leading to scar formation. Hence, the development of innovative biomaterials for wound healing is essential. Natural and synthetic polymers are used extensively for wound dressings and scaffold production. Both natural and synthetic polymers have beneficial properties and limitations, so they are often used in combination to overcome overcome their individual limitations. The use of different polymers in the production of biomaterials has proven to be a promising alternative for the treatment of wounds, as their capacity to accelerate the healing process has been demonstrated in many studies. Thus, this work focuses on describing several currently commercially available solutions used for the management of skin wounds, such as polymeric biomaterials for skin substitutes. New directions, strategies, and innovative technologies for the design of polymeric biomaterials are also addressed, providing solutions for deep burns, personalized care and faster healing.

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“…Neem extract in the nanofiber mat formed an inhibitory zone that synergistically inhibited bacterial cells. Thus, the novel nanofibrous mat may be ideal for wound dressing [73]. Neem gum polysaccharide (NGP) and polyvinyl alcohol (PVA) were blended to produce a nanofiber mat using the electrospinning technique.…”

Section: Azadirachta Indica-incorporated Wound Dressingsmentioning

confidence: 99%

Phytoconstituent-Loaded Nanofibrous Meshes as Wound Dressings: A Concise Review

et al. 2023

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In the past, wounds were treated with natural materials, but modern wound dressings include functional elements to expedite the process of healing and to improve skin recovery. Due to their exceptional properties, nanofibrous wound dressings are now the most cutting-edge and desirable option. Similar in structure to the skin’s own extracellular matrix (ECM), these dressings can promote tissue regeneration, wound fluid transportation, and air ductility for cellular proliferation and regeneration owing to their nanostructured fibrous meshes or scaffolds. Many academic search engines and databases, such as Google Scholar, PubMed, and Sciencedirect, were used to conduct a comprehensive evaluation of the literature for the purposes of this investigation. Using the term “nanofibrous meshes” as a keyword, this paper focuses on the importance of phytoconstituents. This review article summarizes the most recent developments and conclusions from studies on bioactive nanofibrous wound dressings infused with medicinal plants. Several wound-healing methods, wound-dressing materials, and wound-healing components derived from medicinal plants were also discussed.

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Evaluating neem gum-polyvinyl alcohol (NGP-PVA) blend nanofiber mat as a novel platform for wound healing in murine model

Cited by 12 publications

References 24 publications

Teardrop-Shaped Hollow Polystyrene Nanoparticles for Improving the Mechanical and Thermal Properties of Polyvinyl Alcohol-Based Syntactic Foam Films

Teardrop-Shaped Hollow Polystyrene Nanoparticles for Improving the Mechanical and Thermal Properties of Polyvinyl Alcohol-Based Syntactic Foam Films

Polymeric biomaterials for wound healing

Phytoconstituent-Loaded Nanofibrous Meshes as Wound Dressings: A Concise Review

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