Evaluating of fungal contamination in hospital wet cooling systems in Markazi province, Central Iran

Mosayebi, Mahdi; Eslamirad, Zahra; Hajihossein, Reza; Ghorbanzadeh, Behzad; Shahverdi, Mahshid; Didehdar, Mojtaba

doi:10.1016/j.mycmed.2017.04.003

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…It is believed that the hospital environments have different mycoflora and usually spread via staff hands (36,37). In addition, moist surfaces in hospitals protect Candida species for a long time (38).…”

Section: Discussionmentioning

confidence: 99%

Antifungal Susceptibility Profiles of Candida Species Isolated from Ahvaz Jundishapur Educational Hospitals

Taghipour

Rezaei‐Matehkolaei

Mahmoudabadi

2018

Jundishapur J Microbiol

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Background: Candida infections are one of the most important nosocomial infections that have increased by 3.5 to 14 folds over the past decades. Although the sources of infection are human normal flora, hospital environments have an undeniable role. The increased use of antifungals, prolonged prophylaxis, and some organism-associated genetic factors have led to antifungal resistance. Objectives: The aim of the present prospective study was to identify Candida species from clinical specimens, normal flora, and hospital environments. Furthermore, the susceptibility profile of strains to several antifungals was also evaluated. Methods: Two hundred and twenty-one samples (clinical specimens, hospital environments, and personal normal flora) were collected. Samples were inoculated on CHROMagar Candida, incubated at 35°C, and were identified using classical and molecular techniques. Consequently, all recovered isolates were tested against six antifungal drugs, using the microdilution method. Results: Ninety-two Candida strains, belonging to 10 different yeast species, were detected with the most common isolate, Candida albicans (46.74%). Candida albicans made up the majority of species that were obtained from oral samples and non-albicans species with uncommon frequency were obtained from hospital environment samples. Miconazole was a unique antifungal, towards which all strains were sensitive. However, most of the isolates were also sensitive to fluconazole. Conclusions: Although resistance to amphotericin B, terbinafine, fluconazole, caspofungin, and itraconazole was found among C. albicans and non-albicans species, however, miconazole is the most effective antifungals against all strains.

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Section: Discussionmentioning

confidence: 99%

Antifungal Susceptibility Profiles of Candida Species Isolated from Ahvaz Jundishapur Educational Hospitals

Taghipour

Rezaei‐Matehkolaei

Mahmoudabadi

2018

Jundishapur J Microbiol

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“…Aspergillosis can be categorized in many forms, such as invasive, chronic, saprophytic, and allergic. 34 Aspergillosis is a major concern for the healthcare system and scientific communities since they cause deadly diseases in patients with blood malignancies. 35,36 Aspergillus species specifically cause infections in the respiratory and gastrointestinal tract and skin.…”

Section: Aspergillosismentioning

confidence: 99%

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

Shariati¹,

Moradabadi²,

Chegini³

et al. 2020

IDR

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In patients with hematologic malignancies due to immune system disorders, especially persistent febrile neutropenia, invasive fungal infections (IFI) occur with high mortality. Aspergillosis, candidiasis, fusariosis, mucormycosis, cryptococcosis and trichosporonosis are the most important infections reported in patients with hematologic malignancies that undergo hematopoietic stem cell transplantation. These infections are caused by opportunistic fungal pathogens that do not cause severe issues in healthy individuals, but in patients with hematologic malignancies lead to disseminated infection with different clinical manifestations. Prophylaxis and creating a safe environment with proper filters and air pressure for patients to avoid contact with the pathogens in the surrounding environment can prevent IFI. Furthermore, due to the absence of specific symptoms in IFI, rapid and accurate diagnosis reduces the mortality rate of these infections and using molecular techniques along with standard mycological methods will improve the diagnosis of disseminated fungal infection in patients with hematologic disorders. Amphotericin B products, extended-spectrum azoles, and echinocandins are the essential drugs to control invasive fungal infections in patients with hematologic malignancies, and according to various conditions of patients, different results of treatment with these drugs have been reported in different studies. On the other hand, drug resistance in recent years has led to therapeutic failures and deaths in patients with blood malignancies, which indicates the need for antifungal susceptibility tests to use appropriate therapies. Life-threatening fungal infections have become more prevalent in patients with hematologic malignancies in recent years due to the emergence of new risk factors, new species, and increased drug resistance. Therefore, in this review, we discuss the different dimensions of the most critical invasive fungal infections in patients with hematologic malignancies and present a list of these infections with different clinical manifestations, treatment, and outcomes.

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“…The high ratio of positive samples (97.3%) agree with several previous studies it was affected by different factors include time of collection, type of sample and location. It was (38%) in wet cooling system in Iran (Mosayebi and Eslamirad, et al, 2017) while it (96%) air samples of OP in Poland . The isolated fungi from (AC) in the current study are common as outdoor airborne (Ramddn and Salih, 2010;Al-Bader, 1992) and their relation with respiratory infections is quietly known (Al-Bader, Ahmood, Majeed, and Al-Hamdani, 2013; Curtis, Liberman, Stark, and Veter, 2004).…”

Section: Discussionmentioning

confidence: 97%

Fungal Contamination of Airconditioner Units in Five Hospitals of Erbil Province- Kurdistan Region /Iraq

Al-Bader¹,

Ismael²,

Ahmood³

2018

SJUOZ

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During April 2018, 75samples were collected from five hospitals in Erbil city. Samples were taken by sterile cotton swabs from the air dispenser window of air conditioner units (ACU) . They were cultured directly on Sabouraud's dextrose agar incubated at 25oC ±2. The samples were collected from five departments in each hospital include out-patient ward (OP),in-patient ward (IP), emergency room (ER), intensive care unit(ICU), and operation theater (OT). A total of (410) fungal colonies were counted, they belong to13 genera include ten hyphomycetes and only one of zygomycetes ,basidiomycetes , and hemiascomycetes. Penicillium represented in the highest total occurrence (40%) followed by Aspergillus(38.66%) and Alternaria (21.33%). The total frequency showed that Candidawas the highest (30%) followed by Penicillium(27.56%) and Aspergillus(13.17%). The highest density of filamentous fungi (no. of colony/sample) was detected in OP=16.75, and the lowest in OT=1.5. The diversity of isolates showed that ( 9) genera were recorded from ER(60%) and only one in OP (6%). All recorded genera in current study were regarded as indoor air pollutants. The predominant genera Alternaria, Aspergillus, Penicillium ,Cladosporiumand Candida are well-known allergens and may cause several pulmonary disorders as well as fetal infections in particular cases.

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Evaluating of fungal contamination in hospital wet cooling systems in Markazi province, Central Iran

Cited by 9 publications

References 18 publications

Antifungal Susceptibility Profiles of Candida Species Isolated from Ahvaz Jundishapur Educational Hospitals

Antifungal Susceptibility Profiles of Candida Species Isolated from Ahvaz Jundishapur Educational Hospitals

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

Fungal Contamination of Airconditioner Units in Five Hospitals of Erbil Province- Kurdistan Region /Iraq

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