Evaluating outcomes of endoscopic full-thickness plication for gastroesophageal reflux disease (GERD) with impedance monitoring

Renteln, Daniel von; Schmidt, Arthur; Riecken, Bettina; Caca, Karel

doi:10.1007/s00464-009-0723-9

Cited by 15 publications

(11 citation statements)

References 54 publications

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“…The data of this study clearly demonstrate that symptom improvement does not apply to the placebo effect, as documented by the results of MII monitoring. Furthermore, previously reported MII findings by von Renteln et al, 24 who evaluated gastroplication outcomes 6 months after procedure are confirmed here. The study demonstrates a significant reduction of DeMeester scores and of total, acid, proximal, upright, and recumbent reflux episodes, despite unchanged LES parameters.…”

Section: Discussionsupporting

confidence: 89%

Subjective and objective data on esophageal manometry and impedance pH monitoring 1 year after endoscopic full-thickness plication for the treatment of GERD by using multiple plication implants

Koch

Kaindlstorfer

Antoniou

et al. 2013

Gastrointestinal Endoscopy

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Section: Discussionsupporting

confidence: 89%

Subjective and objective data on esophageal manometry and impedance pH monitoring 1 year after endoscopic full-thickness plication for the treatment of GERD by using multiple plication implants

Koch

Kaindlstorfer

Antoniou

et al. 2013

Gastrointestinal Endoscopy

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“…We chose to measure reflux postoperatively with the intent to demonstrate that the TIF procedure produces objectively identifiable changes in the amount of esophageal acid exposure that correlate with symptom improvement. Utilization of a telemetry capsule pH probe was favored over transnasal impedance testing because of patient acceptance, even though it did not provide us with information on nonacid reflux events [47, 48]. In our research protocol we defined pH-metric success by normalization of one or more of the acid reflux characteristics such as acid exposure, number of refluxates, or DeMeester score.…”

Section: Discussionmentioning

confidence: 99%

Clinical and pH-metric outcomes of transoral esophagogastric fundoplication for the treatment of gastroesophageal reflux disease

Bell

Freeman

2010

Surg Endosc

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BackgroundTransoral treatment of gastroesophageal reflux disease (GERD) using the EsophyX device enables creation of an esophagogastric fundoplication with potential for better control of reflux than gastrogastric techniques. Efficacy and safety of a rotational/longitudinal esophagogastric transoral incisionless fundoplication (TIF) was evaluated retrospectively using subjective and objective outcomes.MethodsThirty-seven consecutive patients on antisecretory medication and with proven gastroesophageal reflux and limited hiatal hernia underwent TIF for persistent GERD symptoms. Five patients were reoperations for failed laparoscopic fundoplication.ResultsOf the 37 treated patients, 57% were female. The median age was 58 (range = 20–81) years and BMI was 25.5 (range = 15.9–36.1) kg/m2. Sixty-eight percent indicated GERD-associated cough, asthma, or aspiration as a primary complaint and 32% complained of heartburn or regurgitation. The TIF procedures created tight wraps of 230°–330° extending 3–4 cm above the Z-line. Two complications occurred: one mediastinal abscess treated laparoscopically and one postoperative bleeding requiring transfusion. At 6 (range = 3–14) months median follow-up TIF resulted in a significant improvement of both atypical and typical symptoms in 64% and 70–80% of patients, respectively, as indicated by the corresponding GERD health-related quality of life (HRQL) and reflux symptom index (RSI) score reduction by 50% or more compared to baseline on proton pump inhibitors (PPIs). No patient reported problems with dysphagia, bloating, or excess flatulence, and 82% were not taking any PPIs. Reflux characteristics were significantly improved and normalized in 61, 89, and 56% of patients in terms of acid exposure, number of refluxates, and DeMeester scores, respectively. TIF was effective in treating GERD in 75% of patients among whom 54% were in a complete “remission” and 21% were “improved.” The remaining 25% were considered failures, and five (13.5%) patients underwent revision.ConclusionRotational/longitudinal esophagogastric fundoplication using the EsophyX device significantly improved symptomatic and objective outcomes in over 70% of patients at median 6-month follow-up. Post-fundoplication side effects were not reported after TIF.

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“…Furthermore, this treatment option has been showed to eliminate the need for maintenance antacid therapy in a large proportion of patients [11]. Along with subjective symptom improvement, endoscopic plication seems to also improve objective evidence of reflux [12].…”

mentioning

confidence: 98%

Endoscopic full-thickness plication versus laparoscopic fundoplication: a prospective study on quality of life and symptom control

et al. 2011

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Evaluating outcomes of endoscopic full-thickness plication for gastroesophageal reflux disease (GERD) with impedance monitoring

Cited by 15 publications

References 54 publications

Subjective and objective data on esophageal manometry and impedance pH monitoring 1 year after endoscopic full-thickness plication for the treatment of GERD by using multiple plication implants

Subjective and objective data on esophageal manometry and impedance pH monitoring 1 year after endoscopic full-thickness plication for the treatment of GERD by using multiple plication implants

Clinical and pH-metric outcomes of transoral esophagogastric fundoplication for the treatment of gastroesophageal reflux disease

Endoscopic full-thickness plication versus laparoscopic fundoplication: a prospective study on quality of life and symptom control

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