Evaluating posterior vitreous detachment by widefield 23-mm swept-source optical coherence tomography imaging in healthy subjects

Abstract

Posterior vitreous detachment (PVD) is a separation between the posterior vitreous cortex and internal limiting membrane. Although PVD was historically considered an acute event, recent studies using spectral-domain optical coherence tomography (SD-OCT) revealed a gradual progression of PVD in healthy subjects. Although SD-OCT improved PVD studies, the narrow imaging angle and long examination time were problematic to allow wide angle capture. The Xephilio OCT-S1 (Canon), a swept-source OCT (SS-OCT) device, can obtain up to 23-mm of widefield B-scan images in a single acquisition. We used this widefield SS-OCT to quantitatively evaluate the PVD stage in 214 healthy subjects aged 4–89 years and determine whether PVD stages differ between the bilateral eyes of each patient. Age was significantly positively correlated with the overall PVD stage (ρ = 0.7520, P < 0.001). Interestingly, partial PVD occurred in children as young as 5 years, indicating that initial PVD onset may occur much earlier than previously reported. Furthermore, PVD stages of the bilateral eyes were highly consistent in 183 subjects (85.5%). Widefield 23-mm SS-OCT thus revealed that PVD started earlier than anticipated, and age was correlated with the symmetry of PVD stage. Widefield 23-mm SS-OCT may also be clinically useful for the evaluation of diseased eyes.

Imaging rhegmatogenous retinal lesions and peripheral vitreo-retinal interface with wide-field optical coherence tomography

“…VMT, vitreomacular traction syndrome. compared with conventional spectral domain machines, 28 it may still be inferior to B-scan ultrasonography, making the diagnosis of PVD a potential weakness in this study. 29 Furthermore, WF OCT is still an immature technology.…”

Accuracy of biomicroscopy, ultrasonography and spectral-domain OCT in detection of complete posterior vitreous detachment

“…Interestingly, three dimensional OCT images of the optic disc in relatively small sample of patients provided highest sensitivity of 97.4% with reported speci city of 100% [9]. This leads to a conclusion that the newer generation of OCT machines, which can capture greater vitreous depth, with greater width of retinal imagining including both macula and optic nerve head, could lead to better PVD detection on OCT scans in the future [25].…”

Progress of Imaging in Diabetic Retinopathy—From the Past to the Present

“…With this technology, we now can evaluate or predict macular function. The technology is now not only limited to the macular area but is also applied to ultra-widefield imaging [ 42 , 43 , 44 , 45 , 47 ]. Another advantage of OCT technology is its characteristic of relatively low invasiveness.…”

“…Recent swept source OCTA (OCT-S1, Canon) covers not only the macular area but also a wider field (21 × 23 mm) up to periphery [ 47 ], Figure 1 .…”

“…However, OCTA cannot detect leakage from vessels and dynamics of blood flow, like they are easily shown in FA. Recent models of this new modality such as Canon S1 OCTA covers maximum 23 mm × 20 mm area [ 47 ], and around 12 mm square area are covers in widely used instruments as PLEX Elite (Zeiss) [ 25 , 26 , 69 ]. The development of capturing broader areas in a single taking action substitutes panoramic montage OCTA image and has great potential in evaluating NPAs in future.…”