Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

Tillmann, Julian; Ashwood, Karen; Absoud, Michael; Bölte, Sven; Bonnet‐Brilhault, Frédérique; Buitelaar, Jan K.; Calderoni, Sara; Calvo, Rosa; Canal‐Bedia, Ricardo; Canitano, Roberto; Bildt, Annelies de; Gomot, Marie; Hoekstra, Pieter J.; Kaale, Anett; McConachie, Helen; Murphy, Declan; Narzisi, Antonio; Oosterling, Iris J.; Pejovic-Milovancevic, Milica; Persico, Antonio M.; Puig, Olga; Roeyers, Herbert; Rommelse, Nanda; Sacco, Roberto; Scandurra, Valeria; Stanfield, Andrew C.; Zander, Eric; Charman, Tony

doi:10.1007/s10803-018-3510-4

Cited by 98 publications

(71 citation statements)

References 75 publications

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“…In the present study the AMSE scores were not significantly different across the groups of boys and girls which stands in contrast to the findings of Øien et al (2018a, b), who reported of significant differences in the scores for items 4 “Language” (girls scored significantly higher) and 8 “Unusual sensitivities“(girls scored significantly lower) from their study. In contrast to the study by Øien et al (2018b), Tillmann et al (2018) did not find specific sex-related differences in their multi-centre study, which is supported by the findings in this study.…”

Section: Discussionsupporting

confidence: 81%

Autism Mental Status Examination (AMSE): A Valid Instrument in the Evaluation of Pre-school Children with Suspected Autism Spectrum Disorders?

Cederlund

2019

J Autism Dev Disord

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In this study the Autism Mental Status Exam (AMSE) was validated towards ICD-10 Autism Spectrum Diagnoses (ASD) based on an interview with the Diagnostic Interview for Social and Communication Disorders (DISCO-11) with parent(s)/caregiver(s) in a group of 124 children referred for assessment to a clinical assessment unit for pre-school children. The results from the study indicates a Fair relation across the AMSE score and ICD-10 Autism Spectrum Disorder (ASD). AMSE mean score for children not fulfilling criteria for an ASD at the assessment was significantly lower compared to the AMSE mean score for children who acquired an ASD diagnosis in the study. In addition, Vineland-II Parent/caregiver rating questionnaire GAF standard scores showed a reversed correlation to the AMSE mean scores (i.e. higher AMSE mean scores were related to lower Vineland-II GAF standard scores and vice versa).

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Section: Discussionsupporting

confidence: 81%

Autism Mental Status Examination (AMSE): A Valid Instrument in the Evaluation of Pre-school Children with Suspected Autism Spectrum Disorders?

Cederlund

2019

J Autism Dev Disord

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“…At age 5 and younger, boys with autism have more restricted interests and repetitive behaviors than girls diagnosed with autism. 102,103 In contrast, multiple anxiety disorders except for social anxiety disorder are more prevalent in women than men. 104…”

Section: Role Of K V 7 Channels In Repetitive and Compulsive-like Bmentioning

confidence: 99%

Heterozygous loss of epilepsy geneKCNQ2alters social, repetitive and exploratory behaviors

Kim

Patel

Zhang

et al. 2019

Genes Brain and Behavior

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KCNQ/K v 7 channels conduct voltage-dependent outward potassium currents that potently decrease neuronal excitability. Heterozygous inherited mutations in their principle subunits K v 7.2/KCNQ2 and K v 7.3/KCNQ3 cause benign familial neonatal epilepsy whereas patients with de novo heterozygous K v 7.2 mutations are associated with early-onset epileptic encephalopathy and neurodevelopmental disorders characterized by intellectual disability, developmental delay and autism. However, the role of K v 7.2-containing K v 7 channels in behaviors especially autism-associated behaviors has not been described. Because pathogenic K v 7.2 mutations in patients are typically heterozygous loss-of-function mutations, we investigated the contributions of K v 7.2 to exploratory, social, repetitive and compulsive-like behaviors by behavioral phenotyping of both male and female KCNQ2 +/− mice that were heterozygous null for the KCNQ2 gene. Compared with their wild-type littermates, male and female KCNQ2 +/− mice displayed increased locomotor activity in their home cage during the light phase but not the dark phase and showed no difference in motor coordination, suggesting hyperactivity during the inactive light phase. In the dark phase, KCNQ2 +/− group showed enhanced exploratory behaviors, and repetitive grooming but decreased sociability with sex differences in the degree of these behaviors. While male KCNQ2 +/− mice displayed enhanced compulsive-like behavior and social dominance, female KCNQ2 +/− mice did not. In addition to elevated seizure susceptibility, our findings together indicate that heterozygous loss of K v 7.2 induces behavioral abnormalities including autism-associated behaviors such as reduced sociability and enhanced repetitive behaviors. Therefore, our study is the first to provide a tangible link between loss-of-function K v 7.2 mutations and the behavioral comorbidities of K v 7.2-associated epilepsy.

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“…The present study additionally conducted a sensitivity analysis exclusively in boys. Although the clinical presentation of autism may not significantly differ between boys and girls [20], the prevalence of autism is higher in males, and a great majority of the subjects in the current study were boys. Thus, an additional sensitivity analysis was conducted to test whether the study findings would be replicated in boys only, and the results of this subgroup analysis were similar to the findings of the analysis of the entire study sample, thus confirming the reliability of the study.…”

Section: Discussionmentioning

confidence: 67%

Comparison of the Autism Diagnostic Observation Schedule and Childhood Autism Rating Scale in the Diagnosis of Autism Spectrum Disorder: A Preliminary Study

Park

Yoon

et al. 2018

J Korean Acad Child Adolesc Psychiatry

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Objectives: We examined the agreement between the Autism Diagnostic Observation Schedule (ADOS) and the Childhood Autism Rating Scale (CARS) in the diagnosis of autism spectrum disorder. Methods: The ADOS and CARS scores of 78 children were retrospectively collected from a chart review. A correlation analysis was performed to examine the concurrent validity between the two measures. Using the receiver operating characteristic (ROC) curve, we determined the optimal cutoff score of the CARS for identifying autism spectrum disorder. Results: The CARS score was significantly correlated with the ADOS score (r=0.808, p<0.001). Taking ADOS as the ideal standard, the optimal cutoff scores of CARS for identifying autism and autism spectrum were 30 and 24.5, respectively. Conclusion: We determined the optimal cutoff scores of CARS for screening and diagnosing autism spectrum disorder.

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Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

Cited by 98 publications

References 75 publications

Autism Mental Status Examination (AMSE): A Valid Instrument in the Evaluation of Pre-school Children with Suspected Autism Spectrum Disorders?

Autism Mental Status Examination (AMSE): A Valid Instrument in the Evaluation of Pre-school Children with Suspected Autism Spectrum Disorders?

Heterozygous loss of epilepsy geneKCNQ2alters social, repetitive and exploratory behaviors

Comparison of the Autism Diagnostic Observation Schedule and Childhood Autism Rating Scale in the Diagnosis of Autism Spectrum Disorder: A Preliminary Study

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