Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, double blind, placebo controlled clinical trial

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

“…Following the timeframe of the literature search of the MASCC/ISOO guidelines update, 15 RCTs were published addressing interventions for the management of OM in pediatric cancer patients. The new RCTs investigated the use of natural & miscellaneous agents [76][77][78][79][80][81][82], PBM therapy [68,[83][84][85][86], oral cryotherapy [87], G-CSF [88], and KGF-1 vs. chlorhexidine mouthwashes [89]. These newer RCTs suggest efficacy for honey and inefficacy for SCPR.…”

Nutritional problems and their non‐pharmacological treatment in adults undergoing haematopoietic stem cell transplantation—A systematic review

“…These positive effects are not only statistically significant but also clinically relevant. For example, the studies focusing on interventions such as the use of herbal mouth rinses and laser therapy showed that OM duration was reduced by 4–5 days compared to the controls (Braga et al., 2015; Silva et al., 2015; Tavakoli Ardakani et al., 2016). Insufficient nutritional intake for a further 4–5 days due to OM contributes significantly to the deterioration of nutritional status in this vulnerable patient group and increases the risk of malnutrition.…”

“…The clinical practice guidelines for oral mucositis from the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) do not include a recommendation for or against the use of herbal mouth rinses (Lalla et al., 2014). We identified two studies, published after publication of the MASCC/ISOO guidelines, that cited positive effects when chamomile and peppermint/chamomile mouth rinses were used (Braga et al., 2015; Tavakoli Ardakani et al., 2016). However, Braga et al found significant effects in terms of OM incidence, severity and duration, but only at extract dosages of 1% and not for extract dosages of 0.5% or 2% (Braga et al., 2015).…”

Marham‐Mafasel decrease joint inflammation and IL‐1β gene expression in rheumatoid arthritis animal model

“…M. chamomilla was previously administered in the USA, Europe, Western Asia, Australia and other countries (Mehmood et al, 2015). Also, previous studies on herbal medicines have revealed a significant decrease in the inflammation of oral mucositis and atopic eczema in the rat animal model (Ferreira et al, 2015;Srivastava et al, 2010;Tavakoli Ardakani et al, 2016). So, these herbal medicines have the potential to reduce the inflammation and inflammatory factors in RA patients.…”