Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics

Abstract

Computational fluid dynamics (CFD) was used to simulate air flow changes in reconstructed nasal passages based on magnetic resonance imaging (MRI) data from a previous clinical study of 0.05% Oxymetazoline (Vicks Sinex Micromist®). Total-pressure boundary conditions were uniquely applied to accommodate low patency subjects. Net nasal resistance, the primary simulation outcome, was determined using a parallel-circuit analogy and compared across treatments. Relative risk (RR) calculations show that for a 50% reduction in nasal resistance, subjects treated with Sinex® are 9.1 times more likely to achieve this after 8 hr, and 3.2 times more likely after 12 hr compared to Sham.

Effects of Mucosal Decongestion on Nasal Aerodynamics: A Pilot Study

“…Kishore and coauthors applied CFD to investigate 21 NAO patients who underwent magnetic resonance imaging (MRI) before and 8 hours after mucosal decongestion with 0.05% oxymetazoline nasal spray. 25 Mucosal decongestion led to substantial reduction in nasal resistance compared to placebo (puff of air administered with an empty bottle), but unfortunately the numerical values of the data points illustrated on a scatter plot were not reported. Xiao and coauthors 26 applied CFD to investigate 10 healthy subjects who underwent MRI before and 10 minutes after mucosal decongestion with xylometazoline HCL 0.1% drops.…”

“…Limited research has been conducted to quantify the impact of mucosal decongestion on nasal aerodynamics using CFD. Kishore and coauthors applied CFD to investigate 21 NAO patients who underwent magnetic resonance imaging (MRI) before and 8 hours after mucosal decongestion with 0.05% oxymetazoline nasal spray 25 . Mucosal decongestion led to substantial reduction in nasal resistance compared to placebo (puff of air administered with an empty bottle), but unfortunately the numerical values of the data points illustrated on a scatter plot were not reported.…”

Treating acute rhinitis and exacerbations of chronic rhinitis – A role for topical decongestants?

“…The imidazole group of agents such as oxymetazoline and xylometazoline, which have a proven efficacy and safety profile, best fit these requirements (Box 3). 6,7,8,9,10,11,12,13,14,15,16 BOX 2: A thorough history and examination for acute rhinitis.…”

Numerical simulation of thermal water delivery in the human nasal cavity

“…Among the most recent contributions, examples can be found in the framework of surgery planning [27,28], and for the preand post-surgery analysis [29,30,31,32]. Moreover, CFD is becoming a valuable research tool to drive the development and optimization of devices for the treatment of inflammatory disorders [33,34,35,36].…”