Treating acute rhinitis and exacerbations of chronic rhinitis – A role for topical decongestants?

Green, Robin J.; Feldman, Charles; Niekerk, Andre Van; McDonald, Marinda; Friedman, Raymond; Richards, Guy A.

doi:10.4102/safp.v62i1.5053

Cited by 7 publications

(9 citation statements)

References 12 publications

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“…Decongestants are able to shrink blood vessels in the nose and open up nasal passages. Topical nasal decongestant is the most effect agent to act quickly on nasal symptoms, however, there is a high potential for overuse, resulting in side-effect such as elevated blood pressure ( Green et al., 2020 ).…”

Section: Intervention Strategymentioning

confidence: 99%

The Association Between Intestinal Bacteria and Allergic Diseases—Cause or Consequence?

Han

et al. 2021

Front. Cell. Infect. Microbiol.

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The incidence of allergic disorders has been increasing over the past few decades, especially in industrialized countries. Allergies can affect people of any age. The pathogenesis of allergic diseases is complex and involves genetic, epigenetic, and environmental factors, and the response to medication is very variable. For some patients, avoidance is the sole effective therapy, and only when the triggers are identifiable. In recent years, the intestinal microbiota has emerged as a significant contributor to the development of allergic diseases. However, the precise mechanisms related to the effects of the microbiome on the pathogenesis of allergic diseases are unknown. This review summarizes the recent association between allergic disorders and intestinal bacterial dysbiosis, describes the function of gut microbes in allergic disease development from both preclinical and clinical studies, discusses the factors that influence gut microbial diversity and advanced techniques used in microbial analysis. Ultimately, more studies are required to define the host-microbial relationship relevant to allergic disorders and amenable to new therapeutic interventions.

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Section: Intervention Strategymentioning

confidence: 99%

The Association Between Intestinal Bacteria and Allergic Diseases—Cause or Consequence?

Han

et al. 2021

Front. Cell. Infect. Microbiol.

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“…It is critical that any adult or child who is known to have AR and who then develops acute symptoms should be carefully assessed. 8 Mild exacerbations, and those who are well educated as regards their condition, may be self-managed according to an action plan (see Figure 3). However, a patient who has more severe symptoms or has no prior health contact requires a careful history to elicit symptoms and triggers.…”

Section: Clinical Examination and Special Investigations Requiredmentioning

confidence: 99%

“…If an examination is required, it should include the entire upper respiratory tract (nose, ears and throat), as well as the face for signs of an allergic facies. 8 Special investigations, such as allergy testing, may be required if an allergen that is avoidable is suspected. However, testing for viruses, bacteria and other microorganisms from respiratory tract secretions is not appropriate for isolated upper respiratory tract symptoms.…”

Section: Clinical Examination and Special Investigations Requiredmentioning

confidence: 99%

“…14 A recent publication by the same authors as this article recommended that topical decongestants should, as a rule, be used for a maximum of 7-10 days. 8 With regard to the imidazoline derivatives, one study over 18 days indicated that nasal zylometazoline was a stronger decongestant than nasal corticosteroids (mometasone furoate). 15 Another study documented that combining mometasone furoate and oxymetazoline relieved seasonal AR symptoms, including congestion, faster than the intranasal steroid alone.…”

Section: Management Using Topical Decongestants Including Antiinflammatory Strategies For Oxymetazolinementioning

confidence: 99%

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Acute allergic rhinitis

Green

Niekerk

McDonald³

et al. 2020

S Afr Fam Pract

Self Cite

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Allergic rhinitis is a common and troubling condition. Basic management of this condition has been well described. However, acute exacerbations of the chronic condition allergic rhinitis are a seldom discussed or described problem despite the fact that even well-controlled patients frequently have exacerbations. This consideration means that a new approach is necessary to define the management of these patients. There are three important events that illustrate the need for a new therapeutic approach:A person who gets a new diagnosis of allergic rhinitis, but has symptoms for many months or yearsA sufferer of allergic rhinitis who is exposed to an environment that triggers an exacerbationA person who has an exacerbation related to another trigger.Recognition of triggers and management strategies to correctly use ‘relief’ therapies such as topical nasal decongestants is the key to successful management. In addition, the use of an ‘action plan’, as for asthma, is useful.

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“…Although, at first glance, this pathology seems simple and well-studied, but due to its high incidence, the burden on the health care system encourages an in-depth study of it and the search for new and more effective approaches to its treatment [8,9].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Changes in Quality of Life and Local Levels of TNF-α and IL-1β in Patients with Acute Viral Rhinitis

Гребенюк

Hrytsun

Nazarchuk

et al. 2021

JPRI

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Introduction: Acute viral rhinitis is one of the most common pathologies among the population of the globe. Although, at first glance, this pathology seems simple and well-studied, but due to the high incidence, the load it creates on the health care system encourages in-depth study. Aims: To examine the dynamics of changes in quality of life and local levels of TNF-α and IL-1β in patients with acute viral rhinitis in different treatment regimens. Methodology: The prospective study included 84 patients with a confirmed diagnosis of acute viral rhinitis. In accordance with the purpose and objectives of the study, all patients on days 1, 5 and 10, in addition to routine studies, were determined by local levels of TNF-α and IL-1β, as well as to determine the quality of life. Results: In patients of the study group, only partial recovery of local levels of TNF-α and IL-1β and indicators of the physical component of quality of life was observed during 10 days of treatment. The emotional and functional components of quality of life in patients of this study were more correlated than with the physical component and local levels of proinflammatory cytokines, which are objective indicators of the activity of the inflammatory process. Complementing the traditional treatment regimen with 0.25% oxolin in the form of an ointment has reduced the duration of the disease, reduced the incidence of bacterial complications and improved the quality of life of patients with acute viral rhinitis in the short term. Conclusions: The dynamics of local levels of TNF-α and IL-1β reflects the nature of the inflammatory process in the nasal mucosa and clearly correlates with the physical component of quality of life.

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Treating acute rhinitis and exacerbations of chronic rhinitis – A role for topical decongestants?

Abstract: Treating acute rhinitis and exacerbations of chronic rhinitis -A role for topical decongestants? S Afr Fam Pract. 2020;62(1), a5053.

Cited by 7 publications

References 12 publications

The Association Between Intestinal Bacteria and Allergic Diseases—Cause or Consequence?

The Association Between Intestinal Bacteria and Allergic Diseases—Cause or Consequence?

Acute allergic rhinitis

Dynamics of Changes in Quality of Life and Local Levels of TNF-α and IL-1β in Patients with Acute Viral Rhinitis

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