Evaluating the effects of administration of 25-hydroxyvitamin D supplement on serum anti-mullerian hormone (AMH) levels in infertile women

Naderi, Zahra; Kashanian, Maryam; Chenari, Leily; Sheikhansari, Narges

doi:10.1080/09513590.2017.1410785

Cited by 22 publications

(22 citation statements)

References 33 publications

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“…In a study of 30 infertile Iranian women >35 yo with regular cycles but diminished ovarian reserves (as defined by AMH < 0.7 ng/mL) and vitamin D deficiencies or insufficiencies (levels <30 ng/mL), Naderi et al similarly reported a significant increase in serum AMH levels (from 0.39 ± 0.26 to 0.92 ± 0.62 ng/mL, p < 0.000) following three months of 50,000 IU oral vitamin D3 supplementations. In addition, there was a significant positive correlation between the serum levels of 25OH-D posttreatment and AMH levels, with mean AMH levels after treatment being higher in women with sufficient 25OH-D vs. women with insufficient 25OH-D (1.048 ± 0.644 vs. 0.513 ± 0.284 ng/mL ( p = 0.043) [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the six interventional studies included in this systematic review, three out of six studies reported an increase in serum AMH levels in non-PCOS vitamin D-deficient women following both acute [62] and long-term [61,63] vitamin D supplementations (Table 2). In contrast to these three studies, Cappy et al found no changes in serum AMH following vitamin D supplementations in either PCOS or non-PCOS women.…”

Section: Discussionmentioning

confidence: 99%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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“…In addition, heavy metals such as cadmium are increased in aquatic environments through industrial processes and fertilizers and can be introduced to humans through fish [ 13 ]. Moreover, fish is also a source of other compounds, such as vitamin D, which is associated with serum AMH [ 14 ]. Some participants had missing data for a given variable.…”

Section: Methodsmentioning

confidence: 99%

Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

Lee

Chung

Jeong

et al. 2018

Ann of Occup and Environ Med

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BackgroundAnti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age.MethodsIn a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data.ResultsGeometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01).ConclusionsThe results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group.

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“…In vitro studies demonstrated that the AMH gene is upregulated by vitamin D via functional vitamin D response elements that bind the vitamin D receptor (VDR) [6]. There are multiple reports regarding the relationship between AMH and vitamin D and the impact of vitamin D supplementation on AMH levels [32, 13, 16]. When analyzing the available literature, it is clear that most of the studies revealed that supplementation of vitamin D to women with low AMH levels leads to an increase in these levels, thus improving reproductive outcomes [33].…”

Section: Discussionmentioning

confidence: 99%

“…In a vast majority of studies, a significant correlation was observed between AMH and vitamin D levels. Naderi and coworkers suggested that vitamin D supplementation leads to increased serum AMH levels [16]. Slightly different results were obtained by Irani and coworkers who showed that administration of vitamin D in women with PCOS may reduce the AMH levels [17].…”

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome

Szafarowska

Dziech

Kaleta

et al. 2019

J Assist Reprod Genet

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Objective Our study aimed to investigate the relationship between polymorphisms (Apa1, Bsm1, Fok1, and Cdx2) in the VDR gene as well as AMH and AMHR2 genes and their influence on AMH and 25(OH)D levels in PCOS women. Study design Seventy-five patients with PCOS and 23 control women were included. Serum AMH and 25(OH)D levels in patients and controls were measured by enzyme-linked immunosorbent assay (ELISA). Polymorphisms in VDR gene Fok1 C/T (rs2228587), Bsm1 A/G (rs1544410), Apa1 A/C (rs7975232), and Cdx2 A/G (rs11568820) polymorphisms as well as AMH G/T (rs10407022) and AMHR2 A/G (rs2002555) were analyzed using real-time PCR. Results Analysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG (mutant) genotype in the PCOS group as compared with the control group (p < 0.05). The analysis revealed a statistically significant correlation between the presence of FokI and ApaI polymorphisms and AMH levels in PCOS women (p < 0.05). The presence of mutant genotypes (CT, TT) in the Fok1 and (CA, CC) in the Apa1 polymorphisms were associated with higher AMH level in PCOS women (p < 0.05). No statistically significant correlations between AMH and AMHR2 polymorphisms and AMH level were found. Moreover, there was no correlation between AMH and 25(OH)D levels in the PCOS or in the control group. Conclusion It seems that the elevated AMH level is associated with VDR Fokl and Apal polymorphisms, but not with 25(OH)D levels in PCOS women. Further research is needed to determine the role of VDR polymorphism in AMH level in PCOS.

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Evaluating the effects of administration of 25-hydroxyvitamin D supplement on serum anti-mullerian hormone (AMH) levels in infertile women

Cited by 22 publications

References 33 publications

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages

Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome

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