Evaluating the Efficiency of Using Second-Trimester Nasal Bone Hypoplasia as a Single or a Combined Marker for Fetal Aneuploidy

Abstract

,"Evaluating the efficiency of using second-trimester nasal bone hypoplasia as a single or a combined marker for fetal aneuploidy."

Normative curves of fetal nasal bone length for the ethnic Chinese population

“…Using a combination of markers in NB assessments improves the detection of Down syndrome [27]. Previous researches suggest that race and ethnicity significantly affect the expected NBL in the second trimester, indicating the need to establish formulas for estimating NBL that are specific to different races and ethnicities [13].…”

Absent or Shortened Nasal Bone Length and the Detection of Down Syndrome in Second-Trimester Fetuses

“…These studies have shown that some second trimester Down syndrome fetuses do have an apparent absence of the nasal bone whereas others show hypoplasia relative to unaffected fetuses. [2][3][4][5][6][7][8][9] Both the use of MoM and biparietal diameter/ nasal bone ratios seem to provide practical approaches to screening for fetal Down syndrome, because we were unable to demonstrate any significant difference between the two methods. The various studies that have used biparietal diameter/nasal bone ratios have reported widely different sensitivities and specificities for same cutoff (5-7, this study).…”

Investigation of Bone Ratios for Prenatal Fetal Assessment in Taiwanese Population

“…The combination of other makers with the NB assessment was associated with an improvement in detecting the risk of Down syndrome [27]. Thus, there is a need to establish the specific evaluated formulas by NBL with different methods.…”