Normative curves of fetal nasal bone length for the ethnic Chinese population

Chiu, Wei-Hsiu; Tung, Tao‐Hsin; Chen, Y.-s.; Wang, W.-H.; Lee, S.-M.; Horng, Shih-Cheng; Yang, Fu Yi

doi:10.1007/s11845-010-0520-4

Cited by 9 publications

(10 citation statements)

References 25 publications

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“…Japanese median NBL values were higher than our population, except at 16th gestational week where they reported lower median NBL values (Kanagawa et al , 2006). Chinese median NBL values reported by Chiu et al (2011) were also higher than our measurements except at 16th week, where their values were within 95% CI range of our population. We have compared our study's NBL values with measurements from other studies.…”

Section: Discussionsupporting

confidence: 67%

“…Nasal bone length (NBL) has also been measured in the second trimester to identify high‐risk fetuses for DS (Guis et al , 1995; Cicero et al , 2003). However, establishing clear cut‐off NBL values to define nasal bone hypoplasia is difficult because of its variability among fetuses from different racial origins (Guis et al , 1995; Bunduki et al , 2003; Sonek et al , 2003; Chen et al , 2004; Gamez et al , 2004; Kanagawa et al , 2006; Jung et al , 2007; Hung et al , 2008; Chiu et al , 2011; Rahimi‐Sharbaf et al , 2011,). Second trimester normal range of NBL values of fetuses from Caucasian, African‐American, South American, Chinese, Japanese, Korean and Iranian populations have been previously reported (Guis et al , 1995; Bunduki et al , 2003; Sonek et al , 2003; Chen et al , 2004; Gamez et al , 2004; Kanagawa et al , 2006; Jung et al , 2007; Hung et al , 2008; Chiu et al , 2011; Rahimi‐Sharbaf et al , 2011).…”

Section: Introductionmentioning

confidence: 99%

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Second trimester fetal nasal bone length in a low‐risk Turkish population

et al. 2011

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Second trimester fetal nasal bone length in a low‐risk Turkish population

et al. 2011

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“…Data generated in this study demonstrate that the fetal nasal bone length in East African fetuses increases significantly with gestational age, and the regression analysis revealed a linear relationship between fetal nasal bone length and gestational age (Figure ). These findings are consistent with previous studies in which similar linear relationships between fetal nasal bone length and gestational age were reported for populations of different ethnicities …”

Section: Discussionsupporting

confidence: 93%

“…To date, fetal nasal bone lengths have been studied in white, African American, Brazilian, Chinese, Japanese, Korean, Indian, and Turkish populations, and significant variations in fetal nasal bone lengths at all ages of gestation have been reported . For a direct comparison, data for different ethnic groups at 20 weeks’ gestation (5th and 50th percentiles) are summarized in Table .…”

Section: Discussionmentioning

confidence: 99%

Fetal Nasal Bone Length in the East African Population

Burn

Markese

Bangdiwala

et al. 2019

J of Ultrasound Medicine

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Objectives-To establish normal ranges of fetal nasal bone length throughout gestation in the East African population and to subsequently compare these measurements with the standardized reference.Methods-A retrospective cross-sectional study was performed at the University of Minnesota from January 2011 to December 2016. Fetal nasal bone length measurements were generated in a midsagittal plane at an angle of insonation of 45 from ultrasound images of 1407 nonanomalous fetuses of 1130 mothers of East African decent between 14 and 40 weeks' gestation. The proportion of fetal nasal bone lengths of less than 5.2 mm at week 20 of gestation in the East African population was then compared with the 5% noted by the standardized reference by a χ 2 test.Results-The fetal nasal bone length increased linearly with advancing gestational age in fetuses of East African mothers (R 2 = 0.53; P < .0001). The fetal nasal bone lengths of the East African fetuses were found to be shorter at all ages of gestation compared with the standard reference. At 20 weeks' gestation 17% (95% confidence interval, 13%-22%) of the nasal bone lengths of the East African fetuses were less than 5.2 mm compared with 5% of white and African American fetuses.Conclusions-Using the standard reference may lead to a greater than 3.5-fold overdiagnosis of hypoplastic nasal bones in the East African population. To improve aneuploidy risk stratification and patient counseling in the East African population, the introduction of a standardized East African-based fetal nasal bone length reference seems warranted.

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“…To prevent measurement error, if the nasal bone was absent or shortened then the angle of the fetal nose was maintained at between 45° and 135°. Each increment was set at a 0.1 mm caliper distance, at the appropriate image magnification, to maintain accuracy [23]. …”

Section: Methodsmentioning

confidence: 99%

Prenatal ultrasonography and Doppler sonography for the clinical investigation of isolated ventricular septal defects in a late second-trimester population

et al. 2014

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BackgroundThe purpose of this study was to evaluate the efficacy of prenatal ultrasonography and Doppler sonography in detecting isolated ventricular septal defects (VSDs) in a late-second-trimester population.MethodsFetal echocardiography, Doppler ultrasound, and biometry were used to evaluate 2,661 singleton fetuses (1,381 male fetuses and 1,280 female fetuses) between 1 August 2006 and 31 May 2010. The efficacy of each fetal biometry, Doppler ultrasound, and nasal bone length (NBL) measurement was evaluated in all of the fetuses. A standard fetal echocardiographic evaluation, including two-dimensional gray-scale imaging and color and Doppler color flow mapping, was performed on all fetuses.ResultsWe detected isolated VSDs in 124 of the 2,661 singleton fetuses between 19 and 24 weeks of gestation. The prevalence of isolated VSDs in the study population was 4.66%. A multiple logistic regression analysis indicated that short fetal NBL (odds ratio = 0.691, 95% confidence interval: 0.551 to 0.868) and the pulsatility index (PI) of the umbilical artery (odds ratio = 8.095, 95% confidence interval: 4.309 to 15.207) and of the middle cerebral artery (odds ratio = 0.254, 95% confidence interval: 0.120 to 0.538) are significantly associated with isolated VSDs.ConclusionLate-second-trimester fetal NBL, umbilical artery PI, and middle cerebral artery PI are useful parameters for detecting isolated VSDs, and can be used to estimate the a priori risk of VSDs in women at high risk and at low risk of isolated VSDs.

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Normative curves of fetal nasal bone length for the ethnic Chinese population

Abstract: Using multiple parameters (GA, BPD and HC) to estimate NBL is more accurate than using than using GA or BPD or HC alone, as indicated by the higher predictive value.

Cited by 9 publications

References 25 publications

Second trimester fetal nasal bone length in a low‐risk Turkish population

Second trimester fetal nasal bone length in a low‐risk Turkish population

Fetal Nasal Bone Length in the East African Population

Prenatal ultrasonography and Doppler sonography for the clinical investigation of isolated ventricular septal defects in a late second-trimester population

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