The changing climate and the projected increase in the variability and frequency of extreme events make accurate predictions of crop yield critically important for addressing emerging challenges to food security. Accurate and timely crop yield predictions offer invaluable insights to agronomists, producers, and decision-makers. Even without considering climate change, several factors including the environment, management, genetics, and their complex interactions make such predictions formidably challenging. This study introduced a statistical-based multiple linear regression (MLR) model for the forecasting of rainfed maize yields in Kansas. The model’s performance is assessed by comparing its predictions with those generated using the Decision Support System for Agrotechnology Transfer (DSSAT), a process-based model. This evaluated the impact of synthetic climate change scenarios of 1 and 2 °C temperature rises on maize yield predictions. For analysis, 40 years of historic weather, soil, and crop management data were collected and converted to model-compatible formats to simulate and compare maize yield using both models. The MLR model’s predicted yields (r = 0.93) had a stronger association with observed yields than the DSSAT’s simulated yields (r = 0.70). A climate change impact analysis showed that the DSSAT predicted an 8.7% reduction in rainfed maize yield for a 1 °C temperature rise and an 18.3% reduction for a 2 °C rise. The MLR model predicted a nearly 6% reduction in both scenarios. Due to the extreme heat effect, the predicted impacts under uniform climate change scenarios were considerably more severe for the process-based model than for the statistical-based model.