Evaluating the Natural Fibre Reinforced Polymer Biocomposite for the Development of Novel Wound Dressing Materials

Malarvizhi, G; Chinnammal, S Karpagam

doi:10.7897/2277-4343.083157

Int. J. Res. Ayurveda Pharm.

2017

DOI: 10.7897/2277-4343.083157

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Evaluating the Natural Fibre Reinforced Polymer Biocomposite for the Development of Novel Wound Dressing Materials

G Malarvizhi¹,

S Karpagam Chinnammal²

Abstract: Natural fibre reinforced polymer biocomposite as 2D laminate wound dressing material was developed and evaluated for its wound healing abilities. Two fibres, thuthi and banana were selected to construct a hybrid composite fibre (HCF). Both thuthi and HCF were reinforced with a polymer, poly vinyl alcohol (PVA) to develop a 2D laminate film material. Developed material was evaluated for its antibacterial activity and wound healing ability using a standard in vitro wound scratch assay method. Antibacterial activ… Show more

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Cited by 2 publications

References 21 publications

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In vitro evaluation of biodegradable nHAP‐Chitosan‐Gelatin‐based scaffold for tissue engineering application

Thariga¹,

Rajakannu²,

Pavithra³

et al. 2019

IET nanobiotechnol.

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The present study focuses on fabrication and characterisation of porous composite scaffold containing hydroxyapatite (HAP), chitosan, and gelatin with an average pore size of 250-1010 nm for improving wound repair and regeneration by Electrospinning method. From the results of X-Ray Diffraction (XRD) study, the peaks correspond to crystallographic structure of HAP powder. The presence of functional group bonds of HAP powder, Chitosan and scaffold was studied using Fourier Transform Infrared Spectroscopy (FTIR). The surface morphology of the scaffold was observed using Scanning Electron Microscope (SEM). The Bioactivity of the Nano composite scaffolds was studied using simulated body fluid solution at 37 ± 1°C. The biodegradability test was studied using Tris-Buffer solution for the prepared nanocomposites [nano Chitosan, nano Chitosan gelatin, Nano based Hydroxyapatite Chitosan gelatin]. The cell migration and potential biocompatibility of nHAPchitosan-gelatin scaffold was assessed via wound scratch assay and were compared to povedeen as control. Cytocompatibility evaluation for Vero Cells using wound scratch assay showed that the fabricated porous nanocomposite scaffold possess higher cell proliferation and growth than that of povedeen. Thus, the study showed that the developed nanocomposite scaffolds are potential candidates for regenerating damaged cell tissue in wound healing process.

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In vitro evaluation of biodegradable nHAP‐Chitosan‐Gelatin‐based scaffold for tissue engineering application

Thariga¹,

Rajakannu²,

Pavithra³

et al. 2019

IET nanobiotechnol.

View full text Add to dashboard Cite

show abstract

In Vitro Antibacterial and Wound Healing Activities Evoked by Silver Nanoparticles Synthesized through Probiotic Bacteria

Vijayakumar¹,

Kim

Rangarajulu

2023

Antibiotics

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The prospective application of probiotics is an adjuvant for the advancement of novel antimicrobial and wound-healing agents. Currently, probiotic bacteria are utilized for the biosynthesis of nanoparticles in the development of innovative therapeutics. The present study aimed at using nanoparticle-conjugated probiotic bacteria for enhanced antibacterial and wound-healing activity. In the present investigation, the probiotic bacteria were isolated from a dairy source (milk from domestic herbivores). They screened for antibacterial activity against infection-causing Gram-negative (Pseudomonas aeruginosa and Escherichia coli) and Gram-positive (Bacillus subtilis and Staphylococcus aureus) pathogens. Further, the probiotic strain with higher bactericidal activity was used to synthesize silver, selenium, and copper nanoparticles. The isolated strain was found to be Lactiplantibacillus plantarum and it only has the ability to synthesize silver nanoparticles. This was verified using Ultra violet-Visible (UV-Vis) spectroscopy, where the test solution turned brown and the greatest UV-Vis absorptions peaked at 425 nm. Optimization studies on the synthesis of AgNPs (silver nanoparticles) are presented and the results show that stable synthesis was obtained by using a concentration of 1mM silver nitrate (AgNO3) at a temperature of 37 °C with pH 8. The FTIR (Fourier transform infrared spectroscopy) study confirmed the involvement of functional groups from the cell biomass that were involved in the reduction process. Additionally, biosynthesized AgNPs showed increased antioxidant and antibacterial activities. The nano silver had a size distribution of 14 nm and was recorded with HR-TEM (high-resolution transmission electron microscopy) examination. The EDX (energy dispersive X-ray) analysis revealed 57% of silver groups found in the nanoparticle production. The biosynthesized AgNPs show significant wound-healing capabilities with 96% of wound closure (fibroblast cells) being observed through an in vitro scratch-wound assay. The cytotoxic experiments demonstrated that the biosynthesized AgNPs are not extremely hazardous to the fibroblast cells. The present study provides a new platform for the green synthesis of AgNPs using probiotic bacteria, showing significant antibacterial and wound-healing potentials against infectious pathogens.

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Evaluating the Natural Fibre Reinforced Polymer Biocomposite for the Development of Novel Wound Dressing Materials

Cited by 2 publications

References 21 publications

In vitro evaluation of biodegradable nHAP‐Chitosan‐Gelatin‐based scaffold for tissue engineering application

In vitro evaluation of biodegradable nHAP‐Chitosan‐Gelatin‐based scaffold for tissue engineering application

In Vitro Antibacterial and Wound Healing Activities Evoked by Silver Nanoparticles Synthesized through Probiotic Bacteria

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