Evaluating the Potential of <sup>188</sup>Re-ECD/Lipiodol as a Therapeutic Radiopharmaceutical by Intratumoral Injection for Hepatoma Treatment

Luo, Tsai-Yueh; Shih, Ying-Hsia; Chen, Chiung‐Yu; Tang, I-Chung; Wu, Yongzhong; Kung, Hong-Chang; Lin, Wuu-Jyh; Lin, Xi‐Zhang

doi:10.1089/cbr.2008.0603

Cited by 12 publications

(12 citation statements)

References 20 publications

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“…Similarly, in the BNF-lip group, iron nanoparticles aggregated in the centre of the tumour and presumed needle track, but also in the vascular spaces at the tumour rim. This is consistent with previous observations of ethiodised oil intratumoural transport properties [48,49]. …”

Section: Resultssupporting

confidence: 94%

Image-guided thermal therapy with a dual-contrast magnetic nanoparticle formulation: A feasibility study

Attaluri

Seshadri

Mirpour

et al. 2016

International Journal of Hyperthermia

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Purpose/objective The aim of this study was to develop and investigate the properties of a magnetic iron oxide nanoparticle–ethiodised oil formulation for image-guided thermal therapy of liver cancer. Materials and methods The formulation comprises bionised nano-ferrite (BNF) nanoparticles suspended in ethiodised oil, emulsified with polysorbate 20 (BNF-lip). Nanoparticle size was measured via photon correlation spectroscopy and transmission electron microscopy. In vivo thermal therapy capability was tested in two groups of male Foxn1nu mice bearing subcutaneous HepG2 xenograft tumours. Group I (n =12) was used to screen conditions for group II (n =48). In group II, mice received one of BNF-lip (n =18), BNF alone (n =16), or PBS (n =14), followed by alternating magnetic field (AMF) hyperthermia, with either varied duration (15 or 20 min) or amplitude (0, 16, 20, or 24 kA/m). Image-guided fluoroscopic intra-arterial injection of BNF-lip was tested in New Zealand white rabbits (n =10), bearing liver VX2 tumours. The animals were subsequently imaged with CT and 3 T MRI, up to 7 days post-injection. The tumours were histopathologically evaluated for distribution of BNF-lip. Results The BNF showed larger aggregate diameters when suspended in BNF-lip, compared to clear solution. The BNF-lip formulation produced maximum tumour temperatures with AMF >20 kA/m and showed positive X-ray visibility and substantial shortening of T1 and T2 relaxation time, with sustained intratumoural retention up to 7 days post-injection. On pathology, intratumoural BNF-lip distribution correlated well with CT imaging of intratumoural BNF-lip distribution. Conclusion The BNF-lip formulation has favourable thermal and dual imaging capabilities for image-guided thermal therapy of liver cancer, suggesting further exploration for clinical applications.

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Section: Resultssupporting

confidence: 94%

Image-guided thermal therapy with a dual-contrast magnetic nanoparticle formulation: A feasibility study

Attaluri

Seshadri

Mirpour

et al. 2016

International Journal of Hyperthermia

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“…One unique form of a particle-based therapy utilizes radioactive pharmaceuticals embedded in glass beads or resin-coated particles [115]. The use of radiopharmaceutics in a modified form of TACE, known as radioembolization, is a promising technique for treating nonresectable hepatic carcinomas.…”

Section: Additional Particle-based Drug Delivery Approaches In Tace Andmentioning

confidence: 99%

“…In order to insure optimal treatments, radioembolization requires blood flow and perfusion to maximize the therapeutic effect of the treatment. In this therapy, administration of radiopharmaceuticals such as yttrium-90 ( 90 Y) or rhenium-188 ( 188 Re) particles results in a high internal tumoricidal radiation source (up to 4993 Gy), which, when delivered to a targeted area, reduces the risk of causing radiation-induced liver disease and can be imaged using SPECT-CT [9,115–118]. However, while radiopharmaceuticals have been demonstrated to be effective in improving survival in patients with unresectable HCC tumors, few studies have compared them to more traditional TACE embolic agents and further studies are required.…”

Section: Additional Particle-based Drug Delivery Approaches In Tace Andmentioning

confidence: 99%

Advances in image-guided Intratumoral Drug Delivery Techniques

Solorio

Patel

et al. 2010

Therapeutic Delivery

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Image-guided drug delivery provides a means for treating a variety of diseases with minimal systemic involvement while concurrently monitoring treatment efficacy. These therapies are particularly useful to the field of interventional oncology, where elevation of tumor drug levels, reduction of systemic side effects and post-therapy assessment are essential. This review highlights three such image-guided procedures: transarterial chemoembolization, drug-eluting implants and convection-enhanced delivery. Advancements in medical imaging technology have resulted in a growing number of new applications, including image-guided drug delivery. This minimally invasive approach provides a comprehensive answer to many challenges with local drug delivery. Future evolution of imaging devices, image-acquisition techniques and multifunctional delivery agents will lead to a paradigm shift in patient care.

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“…Rhenium-188 ( 188 Re, t 1/2 = 16.9 h) is emerging as a promising isotope in nuclear imaging and therapy for clinical use. − 188 Re has several advantageous features, including high energy of β-rays (2.1 MeV, 85%), favorable γ-ray energy (159 keV, 15%), shorter half-life, deep tissue penetration for local treatment (maximum = 11 mm, average = 3.8 mm), and in-house preparation of the 188 W/ 188 Re generator . This unique property of 188 Re is suitable for therapeutics and diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

et al. 2019

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Hepatocellular carcinoma (HCC) is one of the leading causes of mortality worldwide. The aim of the present study was to evaluate the distribution and the therapeutic effect of 188Re-Tin-colloid micro-particles in subcutaneous HCC-bearing mice. The synthesis and characterization of micro-particles labeled with the 188Re isotope were performed. The micro-particles were injected into the tumor site subcutaneously in the BNL HCC-bearing mice with three treatment groups, normal saline, 188Re micro-particles, and 188Re-Tin-colloid micro-particles. The results of biodistribution showed that major radioactivity (188Re) of 188Re-Tin-colloid micro-particles (18.69 ± 4.28 %ID/g) remained at the tumor sites, compared with 188Re micro-particles (0.21 ± 0.12 %ID/g), 24 h post injection. Following the injection of 188Re-Tin-colloid micro-particles for 14 days, all BNL tumors in mice were regressed during the observation period. By contrast, all of the mice treated with normal saline or 188Re micro-particles had died by 24 and 28 days, respectively. The 188Re-Tin-colloid micro-particles demonstrated high accumulation and therapeutic potential in the subcutaneous HCC-bearing mice.

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Evaluating the Potential of ¹⁸⁸Re-ECD/Lipiodol as a Therapeutic Radiopharmaceutical by Intratumoral Injection for Hepatoma Treatment

Abstract: (188)Re-ECD/lipiodol via direct intratumoral injection shows potential for treating hepatoma and warrants further clinical trials.

Cited by 12 publications

References 20 publications

Image-guided thermal therapy with a dual-contrast magnetic nanoparticle formulation: A feasibility study

Image-guided thermal therapy with a dual-contrast magnetic nanoparticle formulation: A feasibility study

Advances in image-guided Intratumoral Drug Delivery Techniques

Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

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Evaluating the Potential of 188Re-ECD/Lipiodol as a Therapeutic Radiopharmaceutical by Intratumoral Injection for Hepatoma Treatment

Abstract: (188)Re-ECD/lipiodol via direct intratumoral injection shows potential for treating hepatoma and warrants further clinical trials.

Cited by 12 publications

References 20 publications

Image-guided thermal therapy with a dual-contrast magnetic nanoparticle formulation: A feasibility study

Image-guided thermal therapy with a dual-contrast magnetic nanoparticle formulation: A feasibility study

Advances in image-guided Intratumoral Drug Delivery Techniques

Evaluation Efficacy of Rhenium-188-Loaded Micro-particles for Radiotherapy in a Mouse Model of Hepatocellular Carcinoma

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Evaluating the Potential of ¹⁸⁸Re-ECD/Lipiodol as a Therapeutic Radiopharmaceutical by Intratumoral Injection for Hepatoma Treatment