To reduce the overdependence on petroleum-based surfactants for the dyeing of polyester fabrics, a series of biodegradable cardanol-based polyethoxylate oligomers (CPm, m = 5, 7 and 9) were synthesised by ethoxylation of cardanol with ethylene oxide. The synthesised compounds were characterised and confirmed by Fourier Transform-infrared spectroscopy and proton nuclear magnetic resonance spectroscopy. In addition, the physical, biodegradable and dyeing-assisting properties of CPm were evaluated through comparison with tristyrylphenol ethoxylates (A typical commercial surfactant). Results revealed that CPm showed a higher hydroxyl value, better dispersing capability and a higher migration percentage than tristyrylphenol ethoxylates. Specifically, CP5 (0.5 g/L) improved the migration percentage by 12.03% compared with tristyrylphenol ethoxylates.The migration performance of the surfactants followed a descending order of CP5 > CP7 > CP9 > tristyrylphenol ethoxylates. Importantly, CP5 displays a higher degradation propensity than tristyrylphenol ethoxylates, demonstrating its biodegradable merit. In summary, the cardanol-based polyethoxylates synthesised through this research are promising biodegradable and effective alternatives to conventional levelling agents for disperse dyeing, which contributes a new strategy to the sustainable development of the textile industry.How to cite this article: Chen K, He J, Tawiah B, Zhou X, Zhou Y. Facile synthesis of a cardanolbased levelling agent as a biodegradable alternative to tristyrylphenol ethoxylates for the dyeing of polyester fabric.