Evaluating the relationship between dental caries number and salivary level of IgA in adults

Abstract

BackgroundDental caries are the most common mouth infectious disease and also chronic disease of childhood. Saliva plays different roles in oral cavity; for example, salivary immunoglobulins play significant role in body and oral immunity. Various studies were conducted on the different effects of IgA on oral cavity, especially dental caries, and reported controversial results. The current study aimed to compare salivary IgA level at different stages of dental caries in adults.Material and MethodsA total of 40 adults, aged 20 to 40 years, referred to the department of oral medicine at Qazvin Faculty of Dentistry, were selected voluntarily based on the number of decayed teeth. Their unstimulated saliva was collected by the spitting method. The cases were assigned to 4 groups each of 10, based on the number of decayed teeth, as follows: Group 1: Caries free, Group 2: With 1 or 2 decayed teeth, Group 3: With 3 or 4 decayed teeth, and Group 4: With 5 or more decayed teeth. None of the cases had systemic diseases or the history of using medicines which affect the quality or quantity of saliva. The salivary IgA level of the cases was measured immunoturbidometrically and analyzed by ANOVA and t test.ResultsSignificant difference was observed between the groups 1 and 4, but there was no significant difference between the other groups.ConclusionsAccording to the results of the current study, the salivary IgA can be considered as an index for the function of immune system, which may be increased by the number of decayed teeth. In fact, the increase of salivary IgA is just the response of immune system to the accumulation of microorganisms and may be the attempt of body to control them. Key words:Saliva, IgA, Dental caries.

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

“…The overall results of the correlation between salivary s-IgA levels and caries were shown in Figure 3 . Salivary s-IgA levels in caries patients (mean ± SD) ranged from 2211.00 ± 778.68 [ 45 ] to 0.1472 ± 0.0710 μg/ml [ 21 ], while those in healthy controls ranged from 3155.10 ± 489.30 [ 5 ] to 0.0939 ± 0.0239 μg/ml [ 21 ]. Due to the heterogeneity of I 2 >50% in the study, the random effect model ( P <0.001) was adopted for data consolidation analysis.…”

Relationship between CD14 and IgA Levels with the Early Childhood Caries Event Children Age 3–5 Years

“…Salivary IgA secretions are believed to be factors that protect dental caries by controlling the growth of cariogenic oral microflora, preventing pathogenic adhesion, and activation of enzymes and toxins from bacteria [26]. Increased levels of sIgA in caries patients are an immune system response as a protective mechanism against the process of dental caries and S. mutans are active in the oral cavity [18]. Neutrophils in saliva are the first defense cells against pathogenic microbes.…”

“…There are three subclasses of immunoglobulins found in saliva, namely, IgA, IgG, and IgM. IgA is the most common immunoglobulin in saliva (about 60%) [18]. The salivary secretory immunoglobulin A (sIgA) can bind specifically to the epitope of S. mutans section, so bacteria cannot bind to the salivary pellicle and S. mutans will not colonize the salivary tooth surface [15].…”

“…The salivary secretory immunoglobulin A (sIgA) can bind specifically to the epitope of S. mutans section, so bacteria cannot bind to the salivary pellicle and S. mutans will not colonize the salivary tooth surface [15]. There is a significant relationship between the amount of IgA and the incidence of caries in children [18]. The high concentration of sIgA in children with ECC is associated with increased antigen exposure, thereby triggering high antibody production [15].…”

Correction of disordered oral immunity in children affected by dental caries with herbal immune modulator “Esberitox”

“…The study of Atler (2007) show that bacteriostatic, bacteriolytic and bactericide characteristics of lysozyme are based on its ability to destroy peptidoglycans of the cell wall and finally lead to their lyses. The researches of (Chawda et al 2011;Chereda et al 2012;Haeri-Araghi et al 2018) demonstrated very controversial findings about the content and the role of s-IgA in oral liquid of children resistant and sensitive to dental caries.…”