2021
DOI: 10.1093/annweh/wxab057
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Evaluating the Theoretical Background of STOFFENMANAGER® and the Advanced REACH Tool

Abstract: STOFFENMANAGER® and the Advanced REACH Tool (ART) are recommended tools by the European Chemical Agency for regulatory chemical safety assessment. The models are widely used and accepted within the scientific community. STOFFENMANAGER® alone has more than 37 000 users globally and more than 310 000 risk assessment have been carried out by 2020. Regardless of their widespread use, this is the first study evaluating the theoretical backgrounds of each model. STOFFENMANAGER® and ART are based on a modified multip… Show more

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Cited by 8 publications
(5 citation statements)
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“…Highlights of the extensive and thorough experts' discussion have been presented in this paper. However, the discussion (see, for example, [10,11,15,20]) is ongoing and requires an independent institution designated to assess the validity and regulatory acceptance of exposure-modelling tools.…”
Section: Discussionmentioning
confidence: 99%
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“…Highlights of the extensive and thorough experts' discussion have been presented in this paper. However, the discussion (see, for example, [10,11,15,20]) is ongoing and requires an independent institution designated to assess the validity and regulatory acceptance of exposure-modelling tools.…”
Section: Discussionmentioning
confidence: 99%
“…Some of the participants considered the foundations of these models as well described and supported with sound scientific evidence in the peer reviewed literature. However, some of the participants argued that further evidence and explanations should be provided about the derivation of model multipliers and of the calibration factors, and about the physical concept of these tools, which, according to them, was not described clearly enough by tool developers [15]. Overall, no consensus was reached at the workshop on this issue, so this topic should be further and extensively addressed in the framework of future independent research studies.…”
Section: Theoretical Background and Validation Of Modelsmentioning
confidence: 99%
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“…Exposure models such as the Targeted Risk Assessment (TRA) [ 6 ], Stoffenmanager ® [ 7 ], and the Advanced REACH Tool (ART) [ 8 ], are now widely used in regulatory risk assessments for industrial chemicals as well as in the management of these and other processes that generate hazardous substances in workplaces [ 5 ]. There has been a recent challenge to the theoretical basis of commonly used exposure models under REACH [ 9 , 10 ] and a robust defence from model authors [ 5 , 11 ]. Recent work suggests that a weighted average of predictions from the TRA, Stoffenmanager ® and ART is more reliable than any one model [ 12 ].…”
Section: Introductionmentioning
confidence: 99%