2022
DOI: 10.1039/d1cc06754k
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Evaluating the therapeutic efficacy of nano-drugs targeting epidermal growth factor receptor

Abstract: Epidermal growth factor receptor (EGFR) targeted nano-drugs facilitates effective diagnosis and treatment of cancer. Herein, the therapeutic efficacy of nano-drugs targeting EGFR was evaluated from the perspective of entry cell...

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Cited by 6 publications
(8 citation statements)
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“…The cell viability in response to drug treatments could be further quantified according to the changes in the fluorescent signals. [ 22 ]…”
Section: Resultsmentioning
confidence: 99%
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“…The cell viability in response to drug treatments could be further quantified according to the changes in the fluorescent signals. [ 22 ]…”
Section: Resultsmentioning
confidence: 99%
“…[ 20,32 ] Under the influence of the drug stimulus, the depolymerization of the cell cytoskeleton led to changes in cell mechanical properties. [ 22 ] Moreover, the DNA tensioners were dragged as the dynamic change of the cell's mechanical force. Once the cell mechanical force exceeded the binding force of the “hairpin” structure of the DNA tensioner, the hairpin structure of the DNA tensioner was opened, resulting in the recovery of fluorescence from the fluorophore.…”
Section: Methodsmentioning
confidence: 99%
“…22 The apoptosis will cause changes in the internal structure and properties of cells, and then lead to changes in mechanical properties. 23 CPT is a cytotoxic alkaloid, which combines the topoisomerase I-DNA complex to inhibit the reconnection step during the relaxation of the DNA superhelix structure, interrupt the synthesis of DNA double strand, and induce cell apoptosis, thereby achieving the therapeutic effect. 24,25 PAMAM-CPT-T7 treatment will affect the mechanical properties of cells, and the promoting effect of Tf on PAMAM-CPT-T7 cellular uptake may also affect the therapeutic efficacy of nano-drugs.…”
mentioning
confidence: 99%
“…It has been reported that drug-treated cells will undergo apoptosis by inducing cytoskeletal depolymerization with decreasing cell stiffness decreasing. , Young’s modulus can be used to reflect the cell stiffness, and the greater the Young’s modulus, the greater the cell stiffness. , Therefore, we used the AFM-based nanoindentation technique to further verify the intracellular delivery efficacy of FA-conjugated nano-drugs in different cell lines. The schematic diagram of the nanoindentation experiment in this report is shown in Figure A.…”
mentioning
confidence: 99%
“…Polyamidoamine (PAMAM) is one of the most developed nano-drug carriers because it is a three-dimensional hyperbranched nanometric polymer with promising potential for drug delivery. 26 DOX shows antitumor activity because it has an anthracycline skeleton and produces reactive oxygen species (ROS), which causes DNA damage. 27 Therefore, DOX is selected and encapsulated into the G5-PAMAM to synthesize FA targeting nano-drug.…”
mentioning
confidence: 99%