Evaluating Thyroid Function Tests in Patients with Kidney Disease

Praw, Stephanie Smooke; Way, Jennifer S; Weiss, Rebecca

doi:10.1007/978-3-319-97765-2_7

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…In response to feedback inhibition of T3 and T4, the pituitary gland produces TSH, the levels of which are reduced in CKD patients due to blunted TSH response, blunted responses to thyrotropin releasing hormone (TRH), low renal clearance of TSH, and lower response of TRH. This can also take place due to non-thyroidal illness (NTI) which returns to normal after resolution from CKD [27] . Reduction in the levels of thyroid hormones in CKD patients occurs regardless of age and sex.…”

Section: Thyroid Hormone Levelmentioning

confidence: 99%

Evaluation of Thyroid Hormones and Some Biochemical Variables in Patients with Chronic Kidney Disease

Salih

Yenzeel

AL-Sa’ady

2020

eijs

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Chronic kidney disease (CKD) is a permanent loss of kidney function which is diagnosed when the glomerular filtration rate (GFR) is under 60 ml\min\1.73m2 for more than three months. The present study was conducted at Kidney Transplant and Dialysis Center in the Medical City in Baghdad from October 2018 to April 2019. Sixty CKD patients with an age ranged of 40 to 65 years and 25 healthy subjects were involved in this study. Blood samples were collected to evaluate the levels of kidney function parameters and thyroid hormones. The levels of urea, creatinine and uric acid showed highly significant (p ≤ 0.01) increases in CKD patient in comparison with the control group, while the values of GFR and creatinine clearance showed highly significant (p ≤ 0.01) decreases. The results of thyroid hormones showed highly significant (p < 0.01) decreases in the levels of T3 and T4 along with a highly significant (p < 0.01) increase in the level of TSH in the patients.

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Section: Thyroid Hormone Levelmentioning

confidence: 99%

Evaluation of Thyroid Hormones and Some Biochemical Variables in Patients with Chronic Kidney Disease

Salih

Yenzeel

AL-Sa’ady

2020

eijs

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“…Various studies have that lipid profile abnormalities exist in people with CKD, including considerable hypertriglyceridemia [3] , elevated total cholesterol, and low HDL levels in CKD patients. Dry skin, cold sensitivity, low basal metabolic lethargy, edema, and a sallow complexion are common indications and symptoms of thyroid dysfunction in patients with CKD [4][5][6][7] . Several investigations of thyroid function in uremic patients have been conducted, with varying outcomes.…”

Section: Introductionmentioning

confidence: 99%

A Cross-sectional Study on the Evaluation of Thyroid Hormone Levels and Lipid Profile in Chronic Kidney Disease Patients and to Establish Their Correlation with Disease Severity

Sharma

Patidar

Jadon

et al. 2022

International Journal of Medical Arts

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Article informationBackground: Chronic kidney disease [CKD] is linked to poor kidney function and a persistent decrease in glomerular filtration rate. Almost no lipid profile anomalies in CKD to patho-physiologically notable variations in lipid profile in patients with CKD such as raised triglycerides and low high-density lipoprotein levels have been reported in Indian research proving the pathophysiological link of CKD with Lipid profile. Aim of the Study:To estimate the thyroid hormone level and lipid profile in chronic kidney disease patients and to establish a correlation between them.Patients and Methods: CKD patients with moderate to severe disease, irrespective of gender, within the age groups 20-90 years were included in the study. Moderate CKD [stage 3] is defined as an estimated glomerular filtration rate [eGFR] of 30-60 ml/min, whereas severe CKD [stages 4 and 5] is defined as an eGFR of less than 30 ml/min & patients on maintenance hemodialysis were included. Blood urea, Serum creatinine, Lipid profile, TSH, total T3, and total T4 values of subjects were obtained and analysed. CKD staging was done on eGFR.Results: Our study included 123 CKD patients who met the criteria for the disease. 95 % of the patients had high TSH levels, 48% had low T3 levels, and 95 % had low T4 levels. Out of 123 patients, 87% [N=108] patients had deranged lipid profiles. Conclusion:The study concluded that there is statistically significant association between Chronic Kidney disease and deranged lipid and thyroid profiles and hypothyroid state.

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Monitoring and Evaluation of Thyroid Function Tests, Serum Electrolytes and Creatinine Levels Before and After 131I Therapy

Mehmood

Khan

Hussain

et al. 2020

EMIDDT

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Background: Serum electrolytes, Creatinine, and thyroid profile play an important role in 131I treated patients of thyroid disorders. Objectives: To determine the effect of radioactive iodine (131I) on renal parameters, serum electrolytes and the correlation among TFT’S, creatinine, and chloride levels before and after I131 treatment in thyroid disorders. Methods: The study was performed on 55 patients of thyrotoxicosis with age ranging from 16-65 years (mean age= 41±14years and BMI=24.8±4.46). The significance of the differences between the results of 1st, 2nd, and 3rd-time serum analysis was assessed by paired Student's t-test. Association between parameters was assessed by Spearman correlation analysis. Results: 40 patients were taking Carbimazole, and 15 were directly recommended for I131 therapy. Strongly significant variations were observed for TFT’S (T3=0.012, T4 =0.017, and TSH=0. 001) during the follow-up treatment. Before taking I131 (Serum analyzed at 1st time), there observed negative correlation of T3(r=-.46, p=0. 002) and TSH (r=-0.31, p=0.02) with creatinine, and positive correlation of TSH(r=0.29,p=0.02) with chloride. BMI was negatively correlated with potassium(r=-0.30, p=0.02). At the 2nd time (after stopping the Carbimazole), no correlation results were observed. Two months after oral administration of 131I, creatinine, and chloride level was significantly increased (p=0.000), (P=0. 03) respectively, but had no correlation with TFT’S. Conclusion: Our findings suggest that patients with goiter (diffused or toxic) have association of TFT’S and BMI with serum electrolytes and creatinine, 131I therapy is also associated with the increase in creatinine and chloride levels of patients leading to kidney problems.

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Evaluating Thyroid Function Tests in Patients with Kidney Disease

Cited by 4 publications

References 46 publications

Evaluation of Thyroid Hormones and Some Biochemical Variables in Patients with Chronic Kidney Disease

Evaluation of Thyroid Hormones and Some Biochemical Variables in Patients with Chronic Kidney Disease

A Cross-sectional Study on the Evaluation of Thyroid Hormone Levels and Lipid Profile in Chronic Kidney Disease Patients and to Establish Their Correlation with Disease Severity

Monitoring and Evaluation of Thyroid Function Tests, Serum Electrolytes and Creatinine Levels Before and After 131I Therapy

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