Evaluation and Comparison of Daiokanzoto and Lubiprostone for Constipation: A Retrospective Cohort Study

Yoshida, Aya; Hirose, Tatsuya; Kuroda, Ayaka; Mitsuoka, Machiko; Shinoda, Yasutaka; Mori, Keiichiro; Kawachi, Yuki; Tanaka, Kouji; Takeda, Atsuko; Sugiyama, Tadashi; Yoshimura, Tomoaki

doi:10.1248/bpb.b18-00532

Cited by 6 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Daiokanzoto (TJ-84) is a Kampo medicine consisting of rhubarb and licorice and is used as a drug in Japan [ 171 ]. Therefore, Fournier-Larente et al investigated the therapeutic effect of TJ-84 on Pg - LPS-stimulated HGF [ 172 ].…”

Section: Resultsmentioning

confidence: 99%

A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies

Kim,

Heo,

Chandika

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies

Kim,

Heo,

Chandika

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…Sennoside A and glycyrrhizic acid are the quantitative indicator ingredients specified in the JP18 [ 2 ], as well as the active ingredients of daiokanzoto. Sennoside A has a laxative effect [ 15 ], while glycyrrhizic acid has an anti-inflammatory effect [ 16 ] and is thought to relieve painful defecation and abdominal pain associated with constipation [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Daiokanzoto is a Japanese Kampo formula composed of rhubarb (the rhizome of Rheum palmatum Linneá , Rheum tanguticum Maximowicz, Rheum officinale Baillon, Rheum coreanum Nakai or their interspecific hybrids [ Polygonaceae ]), and glycyrrhiza (the root and stolon, with [unpeeled] or without [peeled] the periderm, of Glycyrrhiza uralensis Fisher or Glycyrrhiza glabra Linneá [Leguminosae]). It is used in the treatment of constipation and its related symptoms, such as heavy head, hot flashes, eczema/dermatitis, acne, anorexia, abdominal bloating, abnormal intestinal fermentation, and hemorrhoids [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the conventional and immersing powdered crude drugs (IPCD) methods for color and extraction of quantitative indicator ingredients in the Kampo formula decoction of daiokanzoto

Naruhashi,

Amaike,

Shiraishi

et al. 2023

J Pharm Health Care Sci

View full text Add to dashboard Cite

Aim The immersing powdered crude drugs (IPCD) method is a quick and simple method for preparing decoctions. Here, the conventional and IPCD methods were compared for the color and extraction of quantitative indicator ingredients in the daiokanzoto decoction solution, and the suitability of the IPCD method was assessed. Methods The color of decoction solutions was visually observed, and the Commission Internationale de L’éclairage (CIE) L*a*b*color parameters were measured using conventional and IPCD methods. The extracted amounts of sennoside A and glycyrrhizic acid, which are quantitative indicator ingredients of rhubarb and glycyrrhiza, respectively, were quantified. Results Using both methods, the decoction solution colors were strong for rhubarb alone and daiokanzoto but weak for glycyrrhiza alone. The color change of daiokanzoto was thought to be primarily caused by rhubarb alone. The L*a*b* values of the decoction solution determined by the IPCD method were comparable to those determined by the conventional method (60 min). Using the conventional method, sennoside A and glycyrrhizic acid were mostly extracted in 10 and 30 min, respectively. Using the IPCD method, both sennoside A and glycyrrhizic acid were fully extracted in 2 min. The IPCD method yielded significantly more sennoside A and glycyrrhizic acid (2 times and 1.5 times, respectively) than the conventional method (60 min). Conclusion The IPCD method was found to be comparable to the conventional method in terms of the color, and using IPCD method, the same or greater amounts of quantitative indicator ingredients of crude drugs in the decoction of daiokanzoto compared to the conventional method. It was suggested that there are limitations to assessing the equivalence of decoctions from decoction color. The IPCD method may be a useful method although it is prudent to use the IPCD method for Kampo formula decoction in clinical practice with a certain degree of caution.

show abstract

“…She took analgesics such as fentanyl and celecoxib, which may cause nausea. Yoshida et al studied the effectiveness and safety of daiokanzoto and lubiprostone retrospectively [20]. They reported that nausea and vomiting were observed in 11.4% and 2.3% respectively.…”

Section: Discussionmentioning

confidence: 99%

Safety of jidabokuippo administration based on adverse event rate

Kitamura

Nakae

Irie

et al. 2022

Traditional & Kampo Medicine

View full text Add to dashboard Cite

Aim The incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate. Methods Adverse events to JDI treatment were observed in 14 patients (adverse event group) while 1090 had none (non‐adverse event group). We compared age, sex, comorbidity, dose, dosing period, concomitant use of Kampo prescription, and concomitant use of analgesics between these two groups. Results The adverse event rate was 1.3%. The most common adverse event was diarrhea caused by rhubarb rhizome (0.6%). The adverse event rate of Glycyrrhiza‐induced pseudoaldosteronism was 0.3%. All symptoms improved on JDI withdrawal or taking JDI after meals. Median duration of JDI was significantly shorter in the adverse event group than in the non‐adverse event group (P = 0.0141). Conclusion The adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome and Glycyrrhiza root.

show abstract

Evaluation and Comparison of Daiokanzoto and Lubiprostone for Constipation: A Retrospective Cohort Study

Cited by 6 publications

References 16 publications

A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies

A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies

Comparison of the conventional and immersing powdered crude drugs (IPCD) methods for color and extraction of quantitative indicator ingredients in the Kampo formula decoction of daiokanzoto

Safety of jidabokuippo administration based on adverse event rate

Contact Info

Product

Resources

About