Évaluation d'une préparation pour nourrissons à teneur réduite en protéines et enrichie en probiotiques, en relais de l'allaitement maternel

Effects of probiotics on child growth: a systematic review

“…Ten of the studies were randomised controlled trials (RCTs) [ 12 , 16 , 27 - 34 ] and two were non-randomised clinical controlled trials [ 13 , 35 ]. Five of the studies were conducted in developing countries in Asia [ 12 , 13 , 16 , 28 , 29 ].…”

“…For this review we defined the study populations as ‘well-nourished’ if the anthropometric measurements showed that the majority of children were not stunted or wasted, and/or if the authors presented them as ‘healthy’; and as ‘under-nourished’ if the majority of children were underweight, stunted or wasted or if the authors presented them as ‘unhealthy’. Eight of the studies were conducted in well-nourished children [ 27 , 29 - 35 ] while four were conducted in under-nourished children [ 12 , 13 , 16 , 28 ]. All the studies in under-nourished children were conducted in developing countries while those on well-nourished children were conducted in developed countries except one study from Indonesia [ 29 ].…”

“…All the studies in under-nourished children were conducted in developing countries while those on well-nourished children were conducted in developed countries except one study from Indonesia [ 29 ]. The age of the participants ranged from less than 28 days [ 30 , 31 , 33 - 35 ], to between one month and five years [ 12 , 13 , 16 , 27 - 29 , 32 ].…”

“…2003 [ 34 ] USA n = 122 6–10 days I(RP + P): Bifdobacterium lactis in reduced protein formula (RP) Duration: Fed till 112 days of age (approximately 4 months of age) Weight and length gain per day between 8-56 days, 56–112 days and 8–112 days I(RP + P): 40 Gender: both M/F ratio I(RP): Reduced protein formula I(RP): 40 Not reported C: Normal protein formula No Follow up C: 42 Puccio et al . 2007 [ 31 ] Italy n = 138 Full term infants (<14 days) I: 2 x 107 Bifdobacterium longum BL999 + 4 g/litre prebiotic in Infant formula Duration: 7 months Mean weight gain, recumbent length, head circumference at 14, 28, 56, 84 and 112 days of age I: 42 Gender M/F: C: Formula without probiotics No Follow up C: 55 I: 20/22 C: 25/30 Huet et al 2006 [ 35 ] France n = 203 1 – 28 days I: Bifdobacterium lactis infant formula Duration: 90 days Daily weight gain, daily increase in height from day 0 to day 90 I: 117 Gender: both M/F ratio not reported C: Infant formula No follow up C: 86 Gil-Campos et al 2011 [ 27 ] Spain N = 137 One month old infants I: 107 cfu/g Lactobacillus fermentum CECT5716 + galactooligosaccharides (0.3 g/100 ml) in infant formula Duration: 5 months Average daily weight gain between baseline (one month) and 4 months of age I: 66 Gender M/F: C: galactooligosaccharides (0.3 g/100 ml) in infant formula No follow up C: 71 I: 34/27 C: 38/22 Undernourished children Sazawal et al 2010 [ 16 ] India n = 624 1–3 years ...…”

“…as a single probiotic [ 13 , 16 , 27 , 28 , 30 , 31 , 33 - 35 ] or multiple probiotics [ 12 , 29 , 32 ]; alone [ 12 , 13 , 27 , 28 , 32 - 35 ] or in combination with other products such as prebiotics [ 16 , 31 ] and long chain polyunsaturated fatty acids (LC-PUFA) [ 30 ] or both prebiotics and LC-PUFA [ 29 ]. Ten of the studies [ 16 , 27 - 35 ] compared a probiotic enriched formula/food/milk in the intervention group with a control group who had the same products but no probiotic added to it. One study compared probiotic food with no intervention (i.e.…”