Pulp of Kent mango (Mangifera indica L.) grown in Côte d’Ivoire was analyzed for it post-harvest profiles in polyphenols, vitamins and amino acids. HPLC method was used for determination of polyphenols, vitamins and amino acids in pulp during 12 post-harvest days. The results revealed the reduction of the polyphenols composition in Kent mango pulp from harvest until the 12th day except gallic acid. This composition is reduced from 9.63±0.52 to 4.31±0.00 mg/100g (gallotanins); 3.22±0.10 to 1.55±0.05 mg/100g (mangiferin); 8.99±0.57 to 2.57±0.00 mg/100g (quercetin) and 3.38±0.34 to 0.92±0.07 mg/100g (isoquercetin). Gallic acid composition increased from 20.39±0.40 to 22.60±0.31 after 6 post-harvest days. The gallic acid content is reduced from 21.34±0.02 to 13.46±0.30 mg/100g between the 6 and 12 post-harvest days. For vitamins of mango pulp, provitamin A content increases from 2nd day (28.03±0.93 µg/100g) to 12th day (50.17±1.12µg/100g). Vitamin B3, B5, and K are stable from 2nd to 4th day before respectively decreased from 1.23±0.06 to 0.10±0.02 mg/100g (vitamin B3); 0.19±0.02 to 0.04±0.01mg/100g (vitamin B5) and 5.00±0.81 to 2.66±0.47µg/100g (vitamin K) between the 6th and 12th day. Vitamins B6 and E contents remained stable during the 6 post-harvest days before decreased until the 12th day from 0.15±0.01 to 0.02±0.01 and 0.63±0.04 to 0.24±0.09 respectively. Concerning amino acids contents, alanin and glutamic acid decreased respectively from 70.66±0.93 to 40.40 mg/100g and 82.33±0.15 to 48.66±0.33 mg/100g between the 2nd and 12th post-harvest days. Valin and tryptophan contents increased respectively from 33.00 to 42.33 mg/100g and 8.33 to 16 mg/100g from the 2nd to 8th day unlike leucin and methionine which decreased during the 12 days of ripening. This study showed that pulp of Kent mango of Côte d’Ivoire has interesting polyphenols, vitamins and amino acids profiles during the 6th and 8th post-harvest day. To our knowledge, this is the first time that a similar study has been carried out on the evolution of polyphenols, vitamins and amino acids content in Kent mango pulp during it post-harvest ripening.