Évaluation des effets prosexuels des extraits de Bridelia ferruginea chez le rat mâle naïf

Watcho, Pierre; Nchegang, B.; Nguelefack, Télesphore Benoît; Kim, Albert

doi:10.1007/s12610-010-0094-z

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…The tests were carried out on a control batch and 3 batches of treated animals. According to the method described by [15], each rat from the control group received by gavage distilled water at 10 mL/ kg bw. Butanolic fraction (BFBu), diluted in distilled water was administered, by gavage, to each of the rats of the 3 test groups, respectively at doses of 50; 500 and 1000 mg/kg bw.…”

Section: Methods Of the Study Of Subacute Toxicitymentioning

confidence: 99%

"Evaluation of an Active Butanol Fraction Effects of Blighia Unijugata (Sapindaceae) Leaves on Some Biochemical Blood Parameters in Male Wistar Rats"

Frédéric¹

2021

BJSTR

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Background and Objective: Blighia unijugata is usually used for its many therapeutic indications in Côte d'Ivoire. This study evaluated the effects of oral administration of an active butanol fraction of Blighia unijugata for 28 days on some biochemical blood parameters of male rats. Materials and Methods:The active butanolic fraction of Blighia unijugata (BFBu) was prepared by successive liquid-liquid extractions of the total ethanolic extract of this plant with water, hexane, chloroform, ethyl acetate and n-butanol. Male albino rats (Rattus norvegicus) of Wistar strain were assigned into four groups of six animals each including a control group receiving distilled water and three test groups receiving BFBu at 50; 500 and 1000 mg/kg bw for 28 days respectively. The substances were administered orally, once a day. Blood samples were taken on days 7; 14; 21 and 28 of treatment by puncture at the level of the orbital sinus of the eye of rats previously anesthetized with ether for the determination of biochemical parameters using an automatic analyzer (KENZA MAX Biochemis Try, France). Biochemical analysis included creatinine, urea, total protein, transaminases (AST, ALT), total cholesterol, HDL-cholesterol, triglycerides, bilirubins (direct and indirect), glucose, electrolytes (sodium, potassium, chlorine, calcium, magnesium) and atherogenicity index.Results: At repeated doses of 50, 500 and 1000 mg/kg bw for 28 days, the extract contributed to a significant increase in certain biochemical parameters such as AST, ALT, urea, creatinine, and total proteins. On the other hand, this same extract evaluated under the previous conditions, caused a decrease in the levels of glucose, total cholesterol, HDL-cholesterol, LDL cholesterol, bilirubins (direct and indirect) and had no noticeable effect on the variation in the concentration of certain electrolytes. Conclusion:At high doses, the active butanol fraction of Blighia unijugata caused mid-term hepatic and renal toxicity. However, at a dose of 50 mg/kg bw, this fraction is non-toxic. This fraction has hypoglycemic effects and does not predispose rats to the risk of atherosclerosis and coronary heart disease.

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Section: Methods Of the Study Of Subacute Toxicitymentioning

confidence: 99%

"Evaluation of an Active Butanol Fraction Effects of Blighia Unijugata (Sapindaceae) Leaves on Some Biochemical Blood Parameters in Male Wistar Rats"

Frédéric¹

2021

BJSTR

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Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats

Watcho

Gatchueng

Deeh

et al. 2019

Journal of Basic and Clinical Physiology and Pharmacology

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Background We investigated the effects of a polyherbal formulation prepared from the extracts of Mondia whitei (Periplocaceae), Dracaena arborea (Dracaenaceae), and Bridelia ferruginea (Euphorbiaceae) (MDB) on the sexual behavior of normal rats (NR) and prediabetic rats (PR). Methods Male Wistar rats were administered with drinking fructose solution (21%) or tap water for 16 weeks. After induction of prediabetic status, NR (n = 30) and PR (n = 30) were randomly distributed into 10 groups of six animals each and orally treated with distilled water (10 mL/kg), sildenafil citrate (5 mg/kg), or MDB (50, 100, or 500 mg/kg) for 21 days. Sexual behavior parameters per series (S) of ejaculation were evaluated on days 1, 7, 14, and 21. Results Drinking fructose solution (21%) induced prediabetic status in rats, characterized by a significant (p < 0.01) increase in glycemia by 43.41% compared with the control group. MDB improved sexual performances of NR and PR by increasing the mount frequency (MF) and the intromission frequency (IF) as well as the number of rats capable of ejaculating. For instance, the MF and the IF were significantly increased in animals administered with MDB for 7 (50 mg/kg, S1 and S2), 14 (100 mg/kg, S3), or 21 days (100 or 500 mg/kg, S2). This increase was more pronounced on days 7 and 14 in NR and PR treated with sildenafil citrate or MDB extracts, respectively. Conclusions The mixture of MDB improved sexual activity in NR and PR. This result may further justify the traditional use of these plants as sexual performance enhancers.

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Évaluation des effets prosexuels des extraits de Bridelia ferruginea chez le rat mâle naïf

Cited by 2 publications

References 24 publications

"Evaluation of an Active Butanol Fraction Effects of Blighia Unijugata (Sapindaceae) Leaves on Some Biochemical Blood Parameters in Male Wistar Rats"

"Evaluation of an Active Butanol Fraction Effects of Blighia Unijugata (Sapindaceae) Leaves on Some Biochemical Blood Parameters in Male Wistar Rats"

Sexual stimulant effects of the mixture of Mondia whitei, Dracaena arborea, and Bridelia ferruginea in normal and prediabetic male Wistar rats

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