Évaluation des marqueurs sériques enzymatiques du coeur chez les lapins traités par Phyllanthus amarus (Euphorbiacées)

Coulibaly, F.; Djyh, Bernard Nazaire; Doumbia, I.; Yapi, H F; Djaman, Allico Joseph

doi:10.1007/s10298-010-0590-5

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…These results are contrary to those of Coulibaly et al [27] who showed that the aqueous extract of Phyllanthus amarus reduced the CPK level over time and induced a cardioprotective effect. The activities of transaminases (AST) and LDH decreased, while that of CPK-MB increased in the groups treated at the dose of 600 mg/kg body weight over time.…”

Section: Discussioncontrasting

confidence: 99%

Cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. Perrier (HAEBTM) in Wistar Rats

Kamo,

Kouassi,

Atto

et al. 2024

AJMB

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Terminalia mantaly H. Perrier is a plant used in traditional medicine for the treatment of various pathologies. However, Terminalia mantaly H. Perrier could present potential health effects on patients. In order to determine the possible cardiotoxic effects of the hydro-alcoholic extract of the bark of Terminalia mantaly H. Perrier, (HAEBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On the other hand, groups 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of Terminalia mantaly H. Perrier corresponding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using spectrophotometric methods using a Cobas C311 ® HITACHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morphological and histopathological analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. The biochemical parameters ALT, LDH, CPK, CPKMB showed no significant change (p < 0.05) in the group of treated rats compared to the controls. However, the activities of ALAT, LDH experienced variations over time and an increase in CPK and CPKMB were observed. Microscopic observations of heart tissue sections from rats treated with the hydroalcoholic extract of Terminalia mantaly showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of Terminalia mantaly did not interfere with the functioning or alter the integrity of the heart.

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Section: Discussioncontrasting

confidence: 99%

Cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. Perrier (HAEBTM) in Wistar Rats

Kamo,

Kouassi,

Atto

et al. 2024

AJMB

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“…Les valeurs normales de l'urée, de la créatinine ainsi que l'absence de glucose, de corps cétoniques dans les urines suggèrent que cet extrait n'a pas modifié la structure et les fonctions rénales. En effet, des travaux ont montré que ces valeurs sont élevées en cas d'altération des reins (Coulibaly et al, 2007).…”

Section: Discussionunclassified

Evaluation de la toxicité d’un extrait aqueux de Sacoglottis gabonensis (Baille) Urban (Humiriaceae) chez les rongeurs, une plante utilisée dans le traitement de l’ulcère de Buruli en Côte d’Ivoire

Koné¹,

Bleyere²,

Yapo³

et al. 2010

International Journal of Biological and Chemical Sciences

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RESUMESacoglottis gabonensis est une plante médicinale qui est utilisée dans le traitement traditionnel de l'ulcère de Buruli en Côte d'Ivoire. En vue d'établir l'innocuité de ce traitement, des tests de toxicité aiguë et subaiguë ont été réalisés. A cet effet, la DL 50 a été déterminée chez la souris, ainsi que les paramètres hématologiques et biochimiques après administration répétée des doses de 3,5 ; 35 et 350 mg/kg de pc de l'extrait aqueux de Sacoglottis gabonensis à des rats pendant 28 jours. La DL 50 obtenue a été supérieure à 5000 mg/kg de pc et l'extrait aqueux a été sans effet sur la plupart des paramètres sanguins dosés. Ces études ont révélé que l'extrait total aqueux de Sacoglottis gabonensis est atoxique à toutes les doses testées.

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“…The doses evaluated were below the maximal tolerated doses of Phyllanthus amarus administrated i.p. [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

Yao

Kamagaté

Amonkan

et al. 2018

BMC Complement Altern Med

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BackgroundPhyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant has been described as a diuretic agent, the underlying mechanism remains unclear. Therefore, the aim of the present study was to investigate the mechanism action of diuretic effects of an ethanolic fraction of Phyllanthus amarus (EFPA) in rats.MethodsEffects of EFPA on urinary excretion were carried out for doses ranging from 5 to 80 mg/kg given by intraperitoneal injection (i.p.) and compared with that induced by furosemide (5 mg/kg) after 8 h. Thereafter, the diuretic activity of EFPA was also evaluated in the presence of indomethacin (5 mg/kg, i.p.) in order to determine the involvement of prostaglandins, after 24 h.ResultsBetween 5 and 80 mg/kg, EFPA induced a significant urinary excretion. The profile of urinary excretion showed that after 2 h, the highest dose of 80 mg/kg induced a urinary volumetric excretion (UVE), which was similar to that induced by furosemide. After 24 h, EFPA at 10 mg/kg increased significantly UVE, Na+ (43 mEq) and Cl¯ (97 mEq) urinary excretions without promoting kaliuresis. In rats pretreated with indomethacin, the urinary excretion and the natriuretic response of EFPA were significantly reduced.ConclusionAltogether, this study has shown that EFPA promotes a significant urinary excretion of water and Na+, confirming its diuretic activity. Moreover, the increased diuresis could be attributed, at least in part, to the involvement of prostaglandins.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2158-0) contains supplementary material, which is available to authorized users.

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Évaluation des marqueurs sériques enzymatiques du coeur chez les lapins traités par Phyllanthus amarus (Euphorbiacées)

Cited by 5 publications

References 9 publications

Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats

Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats

Evaluation de la toxicité d’un extrait aqueux de <i>Sacoglottis gabonensis</i> (Baille) Urban (Humiriaceae) chez les rongeurs, une plante utilisée dans le traitement de l’ulcère de Buruli en Côte d’Ivoire

The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

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Évaluation des marqueurs sériques enzymatiques du coeur chez les lapins traités par Phyllanthus amarus (Euphorbiacées)

Cited by 5 publications

References 9 publications

Cardiac Tolerance of Hydroalcoholic Extract of Bark of &lt;i&gt;Terminalia &lt;/i&gt;&lt;i&gt;mantaly&lt;/i&gt; H. Perrier (HAEBTM) in Wistar Rats

Cardiac Tolerance of Hydroalcoholic Extract of Bark of &lt;i&gt;Terminalia &lt;/i&gt;&lt;i&gt;mantaly&lt;/i&gt; H. Perrier (HAEBTM) in Wistar Rats

Evaluation de la toxicité d’un extrait aqueux de <i>Sacoglottis gabonensis</i> (Baille) Urban (Humiriaceae) chez les rongeurs, une plante utilisée dans le traitement de l’ulcère de Buruli en Côte d’Ivoire

The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

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Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats

Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats