RESUMESacoglottis gabonensis est une plante médicinale qui est utilisée dans le traitement traditionnel de l'ulcère de Buruli en Côte d'Ivoire. En vue d'établir l'innocuité de ce traitement, des tests de toxicité aiguë et subaiguë ont été réalisés. A cet effet, la DL 50 a été déterminée chez la souris, ainsi que les paramètres hématologiques et biochimiques après administration répétée des doses de 3,5 ; 35 et 350 mg/kg de pc de l'extrait aqueux de Sacoglottis gabonensis à des rats pendant 28 jours. La DL 50 obtenue a été supérieure à 5000 mg/kg de pc et l'extrait aqueux a été sans effet sur la plupart des paramètres sanguins dosés. Ces études ont révélé que l'extrait total aqueux de Sacoglottis gabonensis est atoxique à toutes les doses testées.

Abstract-Sesamum radiatum is employed in traditional medicine for parturient women to facilitate deliveries. In this study, the effects of the aqueous leaf extract were examined on the contractile activity of uterine smooth muscle isolated from pregnant Wistar rats (19-21 days). The isometric contractile force of the uterine smooth muscle bundles was recorded by using a strain gauge. S. radiatum aqueous leaf extracts (ESera, 1×10 -4 µg/ml -100µg/ml) showed uterotonic properties. These uterotonic effects were characterized by the increase of the amplitude, the frequency and the basal tone of the uterine smooth muscle strips in normal Mac Ewen solution and by the development of contracture in depolarizing solution and in solution without calcium. Similar effects were observed with Oxytocin (OT, 2.5×10 -14 µg/ml -2.5×10 -9 µg/ml) and misoprostol (Miso, 1×10 -3 µg/ml -0.08µg/ml). In Ca 2+-free solution, the addition of the ESera (10 µg / ml) elicited the development of contracture in the presence of EGTA (0.1 mM). This result suggests that ESera could act on the double calcium flux (intracellular and extracellular) like misoprostol, a synthetic analogue of prostaglandin E 1 . In conclusion, the aqueous leaf extract of S. radiatum (ESera) had uterotonic effects (prostaglandin-like activity) on uterine contraction in pregnant rats.

Spondias mombin L. (Anacardiaceae) is a medicinal plant used in the treatment of digestive disorders in Côte d'Ivoire. In order to verify its safety, the total aqueous stem bark extract is administered orally daily for 28 days, three groups of albino Wistar rats at 250, 500 and 1000 mg / kg body weight. The control group received distilled water. Measurements are made to determine the daily amount of food and the volume of water consumed, the body mass is evaluated each week. A blood sample is taken once a week to determine the effect of the extract on blood biochemical parameters. Repeated administration of total aqueous stem bark extract of Spondias mombin has not deeply disturbed consumption of food and water in all treated rats. Weight gain was observed in all rats throughout the study. Blood biochemical parameters such as glucose, cholesterol and Glutamate Oxaloacetate Transaminase (SGOT) were not changed in rats treated compared to the control group.In contrast, Glutamate-Pyruvate Transaminase (SGPT), creatinine and urea to a lesser degree, increased particularly in patients treated with doses of 500 and 1000 mg / kg body weight to the fourth week of treatment.These studies revealed that the total aqueous stem bark extract of Spondias mombin may be slightly toxic to the liver and kidney when taken in high doses prolonged way.

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