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Spondias mombin L. (Anacardiaceae) is a medicinal plant used in the treatment of digestive disorders in Côte d'Ivoire. In order to verify its safety, the total aqueous stem bark extract is administered orally daily for 28 days, three groups of albino Wistar rats at 250, 500 and 1000 mg / kg body weight. The control group received distilled water. Measurements are made to determine the daily amount of food and the volume of water consumed, the body mass is evaluated each week. A blood sample is taken once a week to determine the effect of the extract on blood biochemical parameters. Repeated administration of total aqueous stem bark extract of Spondias mombin has not deeply disturbed consumption of food and water in all treated rats. Weight gain was observed in all rats throughout the study. Blood biochemical parameters such as glucose, cholesterol and Glutamate Oxaloacetate Transaminase (SGOT) were not changed in rats treated compared to the control group.In contrast, Glutamate-Pyruvate Transaminase (SGPT), creatinine and urea to a lesser degree, increased particularly in patients treated with doses of 500 and 1000 mg / kg body weight to the fourth week of treatment.These studies revealed that the total aqueous stem bark extract of Spondias mombin may be slightly toxic to the liver and kidney when taken in high doses prolonged way.

Antianemc potential of aqueous of Justicia galeopsis leaves was studied using Wistar Albino rats after induction of anemia by phenylhydrazine hydrochloride. Forty rats (20 male and 20 female) subdivided into five groups of eight rats were used. There was a group as control (not anemic) and four other anemic groups which had received by gavage respectively 1 ml/kg of distilled water, 1 ml/kg of body weight of Vitafer (reference drug commonly used to treat anemia), 100 mg/kg of body weight of extract of J. galeopsis leaves cooked during 30 min and 30 mg/kg of body weight of extract of J. galeopsis leaves cooked during 45 min. Hematological parameters (red blood cells, hemoglobin and hematocrit) were analyzed as indices of anemia and the weights of specific organs (liver, spleen and kidney) were evaluated. The results of this investigation had showed that aqueous extract of J. galeopsis leaves cooked improved red blood cells, hemoglobin and hematocrit levels. These extracts were not toxic for liver, spleen and kidney. The administration of 100 mg/kg/day of extract of leaves cooked leaves during 30 min promotes a better recovery rate of the number of red blood cells (94.80 %), hemoglobin level (159.53 %) and hematocrit (117.72 %) than Vitafer and the extract of leaves cooked for 45 min. This is suggestive that aqueous extracts of Justicia galeopsis leaves cooked during 30 min may be exploited during 2 weeks in the treatment of anemia.

Aims: Distemonanthus benthamianus is a widespread plant in West Africa. The bark of its stem is used popularly to treat a variety of illnesses, including fever, bronchitis, rheumatism and malaria. The objective of this work is to evaluate the antipyretic activity of the aqueous extract of the bark of Distemonanthus benthamianus. Materials and Methods: The aqueous extract of the bark of D. benthamianus was tested for their acute oral toxicity in rats. Antipyretic activity was studied in rats of the Wistar strain made feverish after subcutaneous injection of an aqueous suspension of brewer's yeast (Saccharomycete cerevisiae) 20% compared to aspirin. Results: This study showed that administration of the extract at doses of 300, 2000 and 5000 mg / kg / kg dry extract in rats showed no acute toxicity or adverse effects. The results showed that the best antipyretic activity of the extract was recorded at a dose of 800 mg / kg, at the third hour, with a decrease in fever from 39.29 ± 0.14°C to 37.75 ± 0.25°C, i.e. a percentage inhibition of 57% against 62% for the standard molecule (p> 0.05). At this dose, CRP was 3.85 ± 0.1 mg / L compared to that of the healthy control which was 2.78 ± 0.35 mg / L. The results of the albumin assay did not show a significant difference between the treated and untreated fever groups and the healthy control group. In addition, the results showed that the leukocyte level in the feverish control rats is very high (18.84 103 / mm3 of leukocytes) compared to the healthy and treated control rats. Conclusion: The aqueous extract of the bark of Distemonanthus benthamianus is not oral toxic and has interesting antipyretic activities similar to aspirin. The results obtained confirm the validity of the traditional indication of this plant in the management of fever by African populations.

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