Effect of total aqueous stem bark extract of spondias mombin l. on some biochemical and anthropometric parameters in wistar albino rats

Abstract

Spondias mombin L. (Anacardiaceae) is a medicinal plant used in the treatment of digestive disorders in Côte d'Ivoire. In order to verify its safety, the total aqueous stem bark extract is administered orally daily for 28 days, three groups of albino Wistar rats at 250, 500 and 1000 mg / kg body weight. The control group received distilled water. Measurements are made to determine the daily amount of food and the volume of water consumed, the body mass is evaluated each week. A blood sample is taken once a week to determine the effect of the extract on blood biochemical parameters. Repeated administration of total aqueous stem bark extract of Spondias mombin has not deeply disturbed consumption of food and water in all treated rats. Weight gain was observed in all rats throughout the study. Blood biochemical parameters such as glucose, cholesterol and Glutamate Oxaloacetate Transaminase (SGOT) were not changed in rats treated compared to the control group.In contrast, Glutamate-Pyruvate Transaminase (SGPT), creatinine and urea to a lesser degree, increased particularly in patients treated with doses of 500 and 1000 mg / kg body weight to the fourth week of treatment.These studies revealed that the total aqueous stem bark extract of Spondias mombin may be slightly toxic to the liver and kidney when taken in high doses prolonged way.

Biotolerance Study of the Hydroalcoholic Extract of <i>Terminalia mantaly</i> H. Perrier on Rat Renal Activity

“…The decrease in the level of creatinine showed that a dose of 600 mg/kg of body weight of HAETM would not alter the proper functioning of the kidneys. However, our results differ from those of Gbogbo et al [31] who observed a significant difference in the increase of creatinine levels in rats treated with aqueous stem bark extract of Spondias mombin with a dose of 500 and 1000 mg/kg body weight compared to the spleen observed in the controls. They also noticed that the levels of creatinine and urea of treated rats remained lower compared to controls during the first three weeks of the study.…”

Evaluation de la toxicité d’un aphrodisiaque ivoirien d’origine naturelle (aphro) chez le rat

“…Koné et al (2009) ont également montré dans leurs travaux une absence de perturbation sur quelques marqueurs biochimiques hépatiques après administration d'un phytomédicament chez des rats Wistar albinos sur une période de 28 jours aux doses de 3,5 ; 35 et 350 mg/kg de poids corporel. Ces résultats diffèrent cependant de ceux obtenus par Gbogbo et al (2014). Ces derniers ont montré que l'administration subaiguë de l'extrait total aqueux des écorces de tige de spondias mombin L. entraînerait une augmentation graduelle des marqueurs hépatiques au cours du traitement.…”

“…Selon Ariarajah et al (2011) la créatinine est le paramètre d'exploration rénale le plus utilisé et son augmentation sérique peut être expliquée par une atteinte de la fonction rénale. D'autres auteurs ont également montré l'effet toxique de certains phytomédicaments sur la fonction rénale par l'augmentation du taux sérique de la créatinine (Ashraf et al, 2013 ;Gbogbo et al, 2014 ;Awotundea et al, 2019). Hormis la créatinine, les autres paramètres n'ont pas connu de perturbations notables au cours de l'étude.…”